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Deep brain stimulation(DBS)has become an effective intervention for advanced Parkinson's disease, but the exact mechanism of DBS is still unclear. In this review, we discuss the history of DBS, the anatomy and internal architecture of the…

神经元与认知 · 定量生物学 2023-03-24 Yongtong Wu , Kejia Hu , Shenquan Liu

Parkinson's Disease PD is a progressive neurodegenerative disorder that affects motor and cognitive functions with early diagnosis being critical for effective clinical intervention Electroencephalography EEG offers a noninvasive and…

Progressive cognitive decline spanning across decades is characteristic of Alzheimer's disease (AD). Various predictive models have been designed to realize its early onset and study the long-term trajectories of cognitive test scores…

Parkinson's Disease (PD) is characterized by disorders in motor function such as freezing of gait, rest tremor, rigidity, and slowed and hyposcaled movements. Medication with dopaminergic medication may alleviate those motor symptoms,…

Parkinson's disease (PD) is a chronic neurodegenerative disease. Early diagnosis is essential to mitigate the progressive deterioration of patients' quality of life. The most characteristic motor symptoms are very mild in the early stages,…

机器学习 · 计算机科学 2026-01-27 Beatriz Pérez-Sánchez , Noelia Sánchez-Maroño , Miguel A. Díaz-Freire

Parkinson's disease (PD) is a chronic neurodegenerative disease. It shows multiple motor symptoms such as tremor, bradykinesia, postural instability, freezing of gait (FoG). PD is currently diagnosed clinically through physical exam by…

机器学习 · 计算机科学 2026-04-21 Meheru Zannat

By interpreting the forward dynamics of the latent representation of neural networks as an ordinary differential equation, Neural Ordinary Differential Equation (Neural ODE) emerged as an effective framework for modeling a system dynamics…

机器学习 · 计算机科学 2020-10-19 Daehoon Gwak , Gyuhyeon Sim , Michael Poli , Stefano Massaroli , Jaegul Choo , Edward Choi

This work proposes a novel framework for analyzing disease progression using time-aware neural ordinary differential equations (NODE). We introduce a "time-aware head" in a framework trained through self-supervised learning (SSL) to…

People with Parkinson's disease must be regularly monitored by their physician to observe how the disease is progressing and potentially adjust treatment plans to mitigate the symptoms. Monitoring the progression of the disease through a…

音频与语音处理 · 电气工程与系统科学 2022-05-25 Mohammadreza Iman , Amy Giuntini , Hamid Reza Arabnia , Khaled Rasheed

Neural operators have emerged as powerful tools for learning solution operators of partial differential equations. However, in time-dependent problems, standard training strategies such as teacher forcing introduce a mismatch between…

机器学习 · 计算机科学 2025-05-28 Zaijun Ye , Chen-Song Zhang , Wansheng Wang

Parkinsons disease (PD) is a debilitating motor system disorder characterized by progressive loss of movement, tremors, and speech slurring. PD is due to the loss of dopamine-producing brain cells, and symptoms only worsen over time, making…

神经元与认知 · 定量生物学 2014-05-07 Pooja Chandrashekar

Real-world digital Parkinson's disease assessment faces challenges such as heterogeneous modalities, cross-device bias, and incomplete labeling. Existing methods often focus on average predictive performance, lacking the reliability…

机器学习 · 计算机科学 2026-05-12 Wenbin Wei , Ruixiang Gao , Suyuan Yao , Xuanzhen Zhao , Cheng Huang , Hen-Wei Huang

Parkinson's disease (PD) is the most widespread movement condition and the second most common neurodegenerative disorder, following Alzheimer's. Movement symptoms and imaging techniques are the most popular ways to diagnose this disease.…

声音 · 计算机科学 2024-10-28 Paria Ghaheri , Ahmadreza Shateri , Hamid Nasiri

The Path-Dependent Neural Jump Ordinary Differential Equation (PD-NJ-ODE) is a model for predicting continuous-time stochastic processes with irregular and incomplete observations. In particular, the method learns optimal forecasts given…

机器学习 · 统计学 2024-02-06 William Andersson , Jakob Heiss , Florian Krach , Josef Teichmann

Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal…

We present a new data-driven reduced-order modeling approach to efficiently solve parametrized partial differential equations (PDEs) for many-query problems. This work is inspired by the concept of implicit neural representation (INR),…

数值分析 · 数学 2023-11-30 Tianshu Wen , Kookjin Lee , Youngsoo Choi

The Path-dependent Neural Jump ODE (PD-NJ-ODE) is a model for online prediction of generic (possibly non-Markovian) stochastic processes with irregular (in time) and potentially incomplete (with respect to coordinates) observations. It is a…

机器学习 · 统计学 2024-07-29 Florian Krach , Josef Teichmann

There is great interest in developing radiological classifiers for diagnosis, staging, and predictive modeling in progressive diseases such as Parkinson's disease (PD), a neurodegenerative disease that is difficult to detect in its early…

Parkinson's disease (PD) is a neurodegenerative condition characterized by notable motor and non-motor manifestations. The assessment tool known as the Unified Parkinson's Disease Rating Scale (UPDRS) plays a crucial role in evaluating the…

声音 · 计算机科学 2025-02-14 Arman Mohammadigilani , Hani Attar , Hamidreza Ehsani Chimeh , Mostafa Karami

3D image scans are an assessment tool for neurological damage in Parkinson's disease (PD) patients. This diagnosis process can be automatized to help medical staff through Decision Support Systems (DSSs), and Convolutional Neural Networks…