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External information, such as prior information or expert opinions, can play an important role in the design, analysis and interpretation of clinical trials. However, little attention has been devoted thus far to incorporating external…

应用统计 · 统计学 2013-04-24 Minge Xie , Regina Y. Liu , C. V. Damaraju , William H. Olson

While observational data are routinely used to estimate causal effects of biomedical treatments, doing so requires special methods to adjust for observed confounding. These methods invariably rely on untestable statistical and causal…

统计方法学 · 统计学 2026-03-02 Arman Oganisian

Bayesian tests on the symmetry of the generalized von Mises model for planar directions (Gatto and Jammalamadaka, 2007) are introduced. The generalized von Mises distribution is a flexible model that can be axially symmetric or asymmetric,…

统计理论 · 数学 2021-05-04 Sara Salvador , Riccardo Gatto

We propose a nonparametric method for dynamic prediction in event history analysis with high-dimensional, time-dependent covariates. The approach estimates future conditional hazards by combining landmarking supermodels with gradient…

统计理论 · 数学 2026-01-27 Oliver Lunding Sandqvist

In many application domains, time series are monitored to detect extreme events like technical faults, natural disasters, or disease outbreaks. Unfortunately, it is often non-trivial to select both a time series that is informative about…

统计方法学 · 统计学 2020-05-01 Erik Scharwächter , Emmanuel Müller

Post--marketing pharmacovigilance is essential for identifying adverse drug reactions (ADRs) that elude detection during pre--marketing clinical trials. This study explores a novel approach that integrates an adverse event (AE) ontology…

We investigate an empirical Bayesian nonparametric approach to a family of linear inverse problems with Gaussian prior and Gaussian noise. We consider a class of Gaussian prior probability measures with covariance operator indexed by a…

统计理论 · 数学 2021-02-23 Junxiong Jia , Jigen Peng , Jinghuai Gao

Model-independent searches in particle physics aim at completing our knowledge of the universe by looking for new possible particles not predicted by the current theories. Such particles, referred to as signal, are expected to behave as a…

应用统计 · 统计学 2019-05-31 Alessandro Casa , Giovanna Menardi

Linear mixed effects models are widely used in statistical modelling. We consider a mixed effects model with Bayesian variable selection in the random effects using spike-and-slab priors and developed a variational Bayes inference scheme…

统计方法学 · 统计学 2024-08-15 M-Z. Spyropoulou , J. Hopker , J. E. Griffin

Nonlinear Bayesian update for a prior ensemble is proposed to extend traditional ensemble Kalman filtering to settings characterized by non-Gaussian priors and nonlinear measurement operators. In this framework, the observed component is…

机器学习 · 统计学 2025-03-20 Yoonsang Lee

We consider Bayesian inference in inverse regression problems where the objective is to infer about unobserved covariates from observed responses and covariates. We establish posterior consistency of such unobserved covariates in Bayesian…

统计理论 · 数学 2020-05-04 Debashis Chatterjee , Sourabh Bhattacharya

Assume we observe a finite number of inspection times together with information on whether a specific event has occurred before each of these times. Suppose replicated measurements are available on multiple event times. The set of…

统计理论 · 数学 2020-11-17 Geurt Jongbloed , Frank van der Meulen , Lixue Pang

We present a new approach to the electromagnetic inverse problem that explicitly addresses the ambiguity associated with its ill-posed character. Rather than calculating a single ``best'' solution according to some criterion, our approach…

神经元与认知 · 定量生物学 2007-05-23 David M. Schmidt , John S. George , C. C. Wood

The PE for GW merger events relies on a waveform model calibrated using numerical simulations. Within the Bayesian framework, this waveform model represents the GW signal produced during the merger and is crucial for estimating the…

广义相对论与量子宇宙学 · 物理学 2025-11-25 Sumit Kumar , Max Melching , Frank Ohme

Penalized likelihood and quasi-likelihood methods dominate inference in high-dimensional linear mixed-effects models. Sampling-based Bayesian inference is less explored due to the computational bottlenecks introduced by the random effects…

统计方法学 · 统计学 2025-07-24 Sreya Sarkar , Kshitij Khare , Sanvesh Srivastava

Divergence is not only an important mathematical concept in information theory, but also applied to machine learning problems such as low-dimensional embedding, manifold learning, clustering, classification, and anomaly detection. We…

统计计算 · 统计学 2016-11-22 Kun Yang , Hao Su , Wing Hung Wong

Externally controlled trials are crucial in clinical development when randomized controlled trials are unethical or impractical. These trials consist of a full treatment arm with the experimental treatment and a full external control arm.…

统计方法学 · 统计学 2025-03-11 Chenyin Gao , Xiang Zhang , Shu Yang

We consider joint inversion for two or more unknown parameters from observational data in the Bayesian framework. Standard approaches often either treat the parameters as independent or impose structural similarity through regularisation…

统计方法学 · 统计学 2026-05-04 Ruanui Nicholson , Matti Niskanen , Oliver J. Maclaren , Jari P. Kaipio

We present a survey of some of our recent results on Bayesian nonparametric inference for a multitude of stochastic processes. The common feature is that the prior distribution in the cases considered is on suitable sets of piecewise…

统计理论 · 数学 2024-06-04 Denis Belomestny , Frank van der Meulen , Peter Spreij

We introduce a Bayesian approach to conduct inferential analyses on dyadic data while accounting for interdependencies between observations through a set of additive and multiplicative effects (AME). The AME model is built on a generalized…

应用统计 · 统计学 2018-07-31 Shahryar Minhas , Peter D. Hoff , Michael D. Ward
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