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Causal mediation analysis is widely utilized to separate the causal effect of treatment into its direct effect on the outcome and its indirect effect through an intermediate variable (the mediator). In this study we introduce a functional…

应用统计 · 统计学 2018-05-21 Yi Zhao , Xi Luo , Martin Lindquist , Brian Caffo

Natural experiments are a cornerstone of applied economics, providing settings for estimating causal effects with a compelling argument for treatment randomisation, but give little indication of the mechanisms behind causal effects. Causal…

计量经济学 · 经济学 2025-10-07 Senan Hogan-Hennessy

Causal effect estimation from observational data is one of the essential problems in causal inference. However, most estimation methods rely on the strong assumption that all confounders are observed, which is impractical and untestable in…

统计方法学 · 统计学 2023-02-14 Yubai Yuan , Annie Qu

Mediation analyses allow researchers to quantify the effect of an exposure variable on an outcome variable through a mediator variable. If a binary mediator variable is misclassified, the resulting analysis can be severely biased.…

统计方法学 · 统计学 2024-07-19 Kimberly A. Hochstedler Webb , Martin T. Wells

To estimate direct and indirect effects of an exposure on an outcome from observed data strong assumptions about unconfoundedness are required. Since these assumptions cannot be tested using the observed data, a mediation analysis should…

统计理论 · 数学 2018-03-29 Anita Lindmark , Xavier de Luna , Marie Eriksson

In interventional health studies, causal mediation analysis can be employed to investigate mechanisms through which the intervention affects the targeted health outcome. Identifying direct and indirect (i.e. mediated) effects from empirical…

The goal of mediation analysis is to study the effect of exposure on an outcome interceded by a mediator. Two simple hypotheses are tested: the effect of the exposure on the mediator, and the effect of the mediator on the outcome. When…

统计理论 · 数学 2021-06-01 Yotam Leibovici , Yair Goldberg

Online experimentation is at the core of Booking.com's customer-centric product development. While randomised controlled trials are a powerful tool for estimating the overall effects of product changes on business metrics, they often fall…

人机交互 · 计算机科学 2018-10-31 Bahattin Tolga Öztan , Zoé van Havre , Caio Gomes , Lukas Vermeer

With reference to a stratified case-control procedure based on a binary variable of primary interest, we derive the expression of the distortion induced by the sampling design on the parameters of the logistic model of a secondary variable.…

统计方法学 · 统计学 2024-01-18 Marco Doretti , Minna Genbäck , Elena Stanghellini

The problem of estimating the ratio of the means of a two-component Poisson mixture model is considered, when each component is subject to zero-inflation, i.e., excess zero counts. The. resulting {\it zero-inflated Poisson mixture (ZIPM)…

统计理论 · 数学 2022-03-31 Michael D. Perlman

Analyzing multivariate count data generated by high-throughput sequencing technology in microbiome research studies is challenging due to the high-dimensional and compositional structure of the data and overdispersion. In practice,…

应用统计 · 统计学 2023-11-03 Jingyan Fu , Matthew D. Koslovsky , Andreas M. Neophytou , Marina Vannucci

Missing data is a common challenge in studying treatment effects. In the context of mediation analysis, this paper addresses missingness in the mediator and outcome, focusing on identification. We first consider self-separated missingness…

统计方法学 · 统计学 2026-04-07 Trang Quynh Nguyen , Razieh Nabi , Fan Yang , Grace V. Ringlein , Elizabeth A. Stuart

Social and behavioral scientists are increasingly employing technologies such as fMRI, smartphones, and gene sequencing, which yield 'high-dimensional' datasets with more columns than rows. There is increasing interest, but little…

统计方法学 · 统计学 2019-10-11 Erik-Jan van Kesteren , Daniel L. Oberski

High-dimensional mediation analysis aims to identify mediating pathways and to estimate indirect effects linking an exposure to an outcome. In this paper, we propose a Bayesian framework to address key challenges in these analyses,…

统计方法学 · 统计学 2026-02-13 Youngho Bae , Chanmin Kim , Fenglei Wang , Qi Sun , Kyu Ha Lee

Mediation analysis has become a widely used method for identifying the pathways through which an independent variable influences a dependent variable via intermediate mediators. However, limited research addresses the case where mediators…

统计方法学 · 统计学 2025-06-10 Rui Ren , Haoyi Yang , Qian Xiao , Lingzhou Xue , Yuan Huang

Mediation analysis is a crucial tool for uncovering the mechanisms through which a treatment affects the outcome, providing deeper causal insights and guiding effective interventions. Despite advances in analyzing the mediation effect with…

统计方法学 · 统计学 2025-08-11 Shi Bo , AmirEmad Ghassami , Debarghya Mukherjee

In animal behavior studies, a common goal is to investigate the causal pathways between an exposure and outcome, and a mediator that lies in between. Causal mediation analysis provides a principled approach for such studies. Although many…

Empirical researchers are often interested in not only whether a treatment affects an outcome of interest, but also how the treatment effect arises. Causal mediation analysis provides a formal framework to identify causal mechanisms through…

计量经济学 · 经济学 2022-02-01 Bora Kim

Many epidemiological questions concern potential interventions to alter the pathways presumed to mediate an association. For example, we consider a study that investigates the benefit of interventions in young adulthood for ameliorating the…

统计方法学 · 统计学 2020-07-14 Margarita Moreno-Betancur , Paul Moran , Denise Becker , George C Patton , John B Carlin

Many open problems in machine learning are intrinsically related to causality, however, the use of causal analysis in machine learning is still in its early stage. Within a general reinforcement learning setting, we consider the problem of…

机器学习 · 计算机科学 2022-05-18 Tue Herlau , Rasmus Larsen