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Biological systems perform an astonishing array of dynamical processes -- including development and repair, regulation, behavior and motor control, sensing and signaling, and adaptation, among others. Powered by the transduction of stored…

软凝聚态物质 · 物理学 2025-09-04 James Clarke , Jake McGrath , Colin Johnson , José Alvarado

This article is concerned with stability analysis and stabilization of randomly switched nonlinear systems. These systems may be regarded as piecewise deterministic stochastic systems: the discrete switches are triggered by a stochastic…

最优化与控制 · 数学 2010-09-08 Debasish Chatterjee , Daniel Liberzon

We build a rigorous nonequilibrium thermodynamic description for open chemical reaction networks of elementary reactions. Their dynamics is described by deterministic rate equations satisfying mass action law. Our most general framework…

统计力学 · 物理学 2017-01-13 Riccardo Rao , Massimiliano Esposito

We study local stabilization of nonlinear control systems under explicit gain constraints on the feedback law. Using a quantitative refinement of Brockett's openness condition, we introduce the notion of a maximal continuous openness rate…

最优化与控制 · 数学 2026-02-23 Bryce Christopherson , Farhad Jafari

Quantifying energy flows at nanometer scales promises to guide future research in a variety of disciplines, from microscopic control and manipulation, to autonomously operating molecular machines. A general understanding of the…

统计力学 · 物理学 2018-11-26 Steven J. Large , Raphaël Chetrite , David A. Sivak

A class of chemical reaction networks is described with the property that each positive equilibrium is locally asymptotically stable relative to its stoichiometry class, an invariant subspace on which it lies. The reaction systems treated…

动力系统 · 数学 2013-04-11 Pete Donnell , Murad Banaji

Recent progress in experimental techniques has enabled us to quantitatively study stochastic and flexible behavior of biological systems. For example, gene regulatory networks perform stochastic information processing and their…

统计力学 · 物理学 2018-06-21 Shun Otsubo , Takahiro Sagawa

The deep connection between thermodynamics, computation, and information is now well established both theoretically and experimentally. Here, we extend these ideas to show that thermodynamics also places fundamental constraints on…

生物物理 · 物理学 2014-10-08 Alex H. Lang , Charles K. Fisher , Thierry Mora , Pankaj Mehta

This paper, the second of a two-part series, presents a method for mean-field feedback stabilization of a swarm of agents on a finite state space whose time evolution is modeled as a continuous time Markov chain (CTMC). The resulting…

系统与控制 · 计算机科学 2017-03-29 Shiba Biswal , Karthik Elamvazhuthi , Spring Berman

We consider distributed consensus and vehicular formation control problems. Specifically we address the question of whether local feedback is sufficient to maintain coherence in large-scale networks subject to stochastic disturbances. We…

最优化与控制 · 数学 2013-04-23 Bassam Bamieh , Mihailo R. Jovanović , Partha Mitra , Stacy Patterson

We present a model of adaptive regulatory networks consisting of a simple biologically-motivated rewiring procedure coupled to an elementary stability criterion. The resulting networks exhibit a characteristic stationary heavy-tailed degree…

物理与社会 · 物理学 2020-08-05 Ben D. MacArthur , Rubén J. Sánchez-García , Avi Ma'ayan

Networks of biochemical reactions, like cellular metabolic networks, are kept in non-equilibrium steady states by the exchange fluxes connecting them to the environment. In most cases, feasible flux configurations can be derived from…

分子网络 · 定量生物学 2014-12-01 Daniele De Martino , Fabrizio Capuani , Andrea De Martino

Biological systems rely on robust internal information processing: Survival depends on highly reproducible dynamics of regulatory processes. Biological information processing elements, however, are intrinsically noisy (genetic switches,…

分子网络 · 定量生物学 2009-11-10 Konstantin Klemm , Stefan Bornholdt

This paper concerns the adaptive control problem for a class of nonlinear stochastic systems in which the state update is given by a nonlinear function of linear dynamics plus additive stochastic noise. Such systems arise in a wide range of…

系统与控制 · 电气工程与系统科学 2026-04-09 Lantian Zhang , Bo Wahlberg , Silun Zhang

What can we learn about controlling a system solely from its underlying network structure? Here we adapt a recently developed framework for control of networks governed by a broad class of nonlinear dynamics that includes the major dynamic…

无序系统与神经网络 · 物理学 2017-07-07 Jorge G. T. Zañudo , Gang Yang , Réka Albert

Robust control of complex engineered and biological systems hinges on the integration of feedforward and feedback mechanisms. This is exemplified in neural motor control, where feedforward muscle co-contraction complements sensory-driven…

最优化与控制 · 数学 2026-03-06 Bastien Berret , Frédéric Jean

Autonomous sustained oscillations are ubiquitous in living and nonliving systems. As open systems, far from thermodynamic equilibrium, they defy entropic laws which mandate convergence to stationarity. We present structural conditions on…

动力系统 · 数学 2020-01-07 Bernold Fiedler

It is nontrivial to achieve global zero-error regulation for uncertain nonlinear systems. The underlying problem becomes even more challenging if mismatched uncertainties and unknown time-varying control gain are involved, yet certain…

系统与控制 · 电气工程与系统科学 2022-02-15 Hefu Ye , Yongduan Song

At the nanoscale, random effects govern not only the dynamics of a physical system but may also affect its observation. This work introduces a novel paradigm for coarse graining that eschews the assignment of a unique coarse-grained…

统计力学 · 物理学 2026-02-05 Jann van der Meer , Keiji Saito

Understanding how systems respond to external perturbations is a fundamental challenge in physics, particularly for non-equilibrium and non-stationary processes. The fluctuation-dissipation theorem provides a complete framework for…

统计力学 · 物理学 2026-05-06 Jiming Zheng , Zhiyue Lu