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Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, fold-change detection, entrainment, and…

定量方法 · 定量生物学 2026-01-05 Eduardo D. Sontag

Living cells are continually exposed to environmental signals that vary in time. These signals are detected and processed by biochemical networks, which are often highly stochastic. To understand how cells cope with a fluctuating…

分子网络 · 定量生物学 2012-06-01 Wiet de Ronde , Filipe Tostevin , Pieter Rein ten Wolde

Feedback control mechanisms are ubiquitous in science and technology, and play an essential role in regulating physical, biological and engineering systems. The standard second law of thermodynamics does not hold in the presence of…

量子物理 · 物理学 2020-04-20 Maxime Debiossac , David Grass , Jose Joaquin Alonso , Eric Lutz , Nikolai Kiesel

In this work we analyze and bound the effect of modeling errors on the stabilization of pure states or subspaces for quantum stochastic evolutions. Different approaches are used for open-loop and feedback control protocols. For both, we…

量子物理 · 物理学 2024-09-27 Weichao Liang , Kentaro Ohki , Francesco Ticozzi

We study fundamental performance limitations of distributed feedback control in large-scale networked dynamical systems. Specifically, we address the question of whether dynamic feedback controllers perform better than static (memoryless)…

最优化与控制 · 数学 2019-03-14 Emma Tegling , Partha Mitra , Henrik Sandberg , Bassam Bamieh

The global steady state of a system in thermal equilibrium exponentially favors configurations with lesser energy. This principle is a powerful explanation of self-organization because energy is a local property of a configuration. For…

概率论 · 数学 2024-06-13 Jacob Calvert , Dana Randall

We quantify the influence of the topology of a transcriptional regulatory network on its ability to process environmental signals. By posing the problem in terms of information theory, we may do this without specifying the function…

分子网络 · 定量生物学 2015-06-26 Etay Ziv , Ilya Nemenman , Chris H. Wiggins

Adaptive physical and biological systems continually process fluctuating information from their environments. When the environment is nonstationary, inference itself becomes a nonequilibrium process with thermodynamic cost. We analyse a…

统计力学 · 物理学 2026-03-23 Aditya Gupta

We introduce thermodynamic networks, a general framework for autonomous, physics-based computation using non-equilibrium steady states. These networks are modeled as a collection of finite-size reservoirs that exchange conserved…

Thermal contact is the archetype of non-equilibrium processes driven by constant non-equilibrium constraints when the latter are enforced by reservoirs exchanging conserved microscopic quantities. At a mesoscopic scale only the energies of…

统计力学 · 物理学 2014-12-30 Michel Bauer , Françoise Cornu

Biochemical oscillations are prevalent in living organisms. Systems with a small number of constituents cannot sustain coherent oscillations for an indefinite time because of fluctuations in the period of oscillation. We show that the…

统计力学 · 物理学 2017-06-29 Andre C Barato , Udo Seifert

Neural dynamics of energy-based models are governed by energy minimization and the patterns stored in the network are retrieved when the system reaches equilibrium. However, when the system is driven by time-varying external input, the…

神经元与认知 · 定量生物学 2020-12-25 Kevin S. Chen

We introduce and solve a general model of dynamic response under external perturbations. This model captures a wide range of systems out of equilibrium including Ising models of physical systems, social opinions, and population genetics.…

可精确求解与可积系统 · 物理学 2007-11-19 David D. Chinellato , Marcus A. M. de Aguiar , Irving R. Epstein , Dan Braha , Yaneer Bar-Yam

We consider open quantum systems weakly coupled to thermal reservoirs and subjected to quantum feedback operations triggered with or without delay by monitored quantum jumps. We establish a thermodynamic description of such system and…

统计力学 · 物理学 2015-06-16 Philipp Strasberg , Gernot Schaller , Tobias Brandes , Massimiliano Esposito

This paper analyzes stochastic networks consisting of a set of finite capacity sites where different classes of individuals move according to some routing policy. The associated Markov jump processes are analyzed under a thermodynamic limit…

概率论 · 数学 2009-09-29 Nelson Antunes , Christine Fricker , Philippe Robert , Danielle Tibi

Across all scales of the physical world, dynamical systems can often be usefully represented as abstract networks that encode the system's units and inter-unit interactions. Understanding how physical rules shape the topological structure…

介观与纳米尺度物理 · 物理学 2023-11-28 Abigail N. Poteshman , Mathieu Ouellet , Lee C. Bassett , Danielle S. Bassett

The response of ecosystems to perturbations is considered from a thermodynamic perspective by acknowledging that, as for all macroscopic systems and processes, the dynamics and stability of ecosystems is subject to definite thermodynamic…

生物物理 · 物理学 2008-09-26 K. Michaelian , V. Alonso Chavez

Response lags are generic to almost any physical system and often play a crucial role in the feedback loops present in artificial nanodevices and biological molecular machines. In this paper, we perform a comprehensive study of small…

统计力学 · 物理学 2015-06-23 M. L. Rosinberg , T. Munakata , G. Tarjus

This paper considers a problem of output agreement in heterogeneous networks with dynamics on the nodes as well as on the edges. The control and disturbance signals entering the nodal dynamics are "unmatched" meaning that some nodes are…

系统与控制 · 计算机科学 2015-05-26 Nima Monshizadeh , Claudio De Persis

Feedback control is an effective strategy for stabilizing a desired state and has been widely adopted in maintaining the stability of systems such as flying birds and power grids. By default, this framework requires continuous control input…

适应与自组织系统 · 物理学 2025-10-14 Yuanzhao Zhang , Sean P. Cornelius