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Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of…

化学物理 · 物理学 2015-06-17 Frank Noe , Hao Wu , Jan-Hendrik Prinz , Nuria Plattner

Estimating the state of a dynamical system from a series of noise-corrupted observations is fundamental in many areas of science and engineering. The most well-known method, the Kalman smoother (and the related Kalman filter), relies on…

机器学习 · 统计学 2017-04-24 Luca Ambrogioni , Umut Güçlü , Eric Maris , Marcel van Gerven

Markov state models (MSMs) have been broadly adopted for analyzing molecular dynamics trajectories, but the approximate nature of the models that results from coarse-graining into discrete states is a long-known limitation. We show…

计算物理 · 物理学 2021-05-31 John D. Russo , Jeremy Copperman , David Aristoff , Gideon Simpson , Daniel M. Zuckerman

Modeling joint probability distributions over sequences has been studied from many perspectives. The physics community developed matrix product states, a tensor-train decomposition for probabilistic modeling, motivated by the need to…

机器学习 · 计算机科学 2020-10-22 Siddarth Srinivasan , Sandesh Adhikary , Jacob Miller , Guillaume Rabusseau , Byron Boots

Discrete latent space models have recently achieved performance on par with their continuous counterparts in deep variational inference. While they still face various implementation challenges, these models offer the opportunity for a…

机器学习 · 统计学 2023-08-22 Max Cohen , Maurice Charbit , Sylvain Le Corff

We propose two novel approaches for estimating time-varying effects of functional predictors within a linear functional Cox model framework. This model allows for time-varying associations of a functional predictor observed at baseline,…

统计方法学 · 统计学 2024-12-20 Hongyu Du , Andrew Leroux

Tensor network states and specifically matrix-product states have proven to be a powerful tool for simulating ground states of strongly correlated spin models. Recently, they have also been applied to interacting fermionic problems,…

量子物理 · 物理学 2016-11-22 C. Krumnow , L. Veis , Ö. Legeza , J. Eisert

In this paper, we develop methods of nonlinear filtering and prediction of an unobservable Markov chain with a finite set of states. This Markov chain controls coefficients of AR(p) model. Using observations generated by AR(p) model we have…

概率论 · 数学 2015-03-10 Vasily Vasilyev , Alexander Dobrovidov

Markov switching models (MSMs) are probabilistic models that employ multiple sets of parameters to describe different dynamic regimes that a time series may exhibit at different periods of time. The switching mechanism between regimes is…

机器学习 · 统计学 2019-09-13 Silvia Chiappa

Experiments, in particular on biological systems, typically probe lower-dimensional observables which are projections of high-dimensional dynamics. In order to infer consistent models capturing the relevant dynamics of the system, it is…

统计力学 · 物理学 2025-11-18 Xizhu Zhao , Dmitrii E. Makarov , Aljaž Godec

Many real-valued stochastic time-series are locally linear (Gassian), but globally non-linear. For example, the trajectory of a human hand gesture can be viewed as a linear dynamic system driven by a nonlinear dynamic system that represents…

机器学习 · 计算机科学 2013-01-30 Vladimir Pavlovic , Brendan J. Frey , Thomas S. Huang

We search for digital biomarkers from Parkinson's Disease by observing approximate repetitive patterns matching hypothesized step and stride periodic cycles. These observations were modeled as a cycle of hidden states with randomness…

定量方法 · 定量生物学 2017-11-15 Avinash Bukkittu , Baihan Lin , Trung Vu , Itsik Pe'er

This chapter presents an introduction to Markovian modeling for the analysis of sequence data. Contrary to the deterministic approach seen in the previous sequence analysis chapters, Markovian models are probabilistic models, focusing on…

统计方法学 · 统计学 2023-09-18 Jouni Helske , Satu Helske , Mohammed Saqr , Sonsoles López-Pernas , Keefe Murphy

Predicting future operational risk losses gives rise to a significant challenge due to the heterogeneous and time-dependent structures present in real-world data. Furthermore, stress test exercises require examining the relationship with…

风险管理 · 定量金融 2026-04-24 Nikeethan Selvaratnam , Dorinel Bastide , Clément Fernandes , Wojciech Pieczynski

A stochastic hybrid system, also known as a switching diffusion, is a continuous-time Markov process with state space consisting of discrete and continuous parts. We consider parametric estimation of theQmatrix for the discrete state…

概率论 · 数学 2020-10-14 Masaaki Fukasawa

State space models have long played an important role in signal processing. The Gaussian case can be treated algorithmically using the famous Kalman filter. Similarly since the 1970s there has been extensive application of Hidden Markov…

统计理论 · 数学 2007-06-13 Peter Bickel , Yaacov Ritov , Tobias Rydén

In this paper, we prove that finite state space non parametric hidden Markov models are identifiable as soon as the transition matrix of the latent Markov chain has full rank and the emission probability distributions are linearly…

统计方法学 · 统计学 2013-06-20 Elisabeth Gassiat , Alice Cleynen , Stéphane Robin

Asymptotic properties of Markov Processes, such as steady state probabilities or hazard rate for absorbing states can be efficiently calculated by means of linear algebra even for large-scale problems. This paper discusses the methods for…

性能 · 计算机科学 2017-05-17 Vitali Volovoi

Markov models are often used to capture the temporal patterns of sequential data for statistical learning applications. While the Hidden Markov modeling-based learning mechanisms are well studied in literature, we analyze a…

机器学习 · 统计学 2021-03-25 Devesh K. Jha

Dynamic heterogeneity has often been modeled by assuming that a single-particle observable, fluctuating at a molecular scale, is influenced by its coupling to environmental variables fluctuating on a second, perhaps slower, time scale.…

凝聚态物理 · 物理学 2009-11-07 Gregor Diezemann , Gerald Hinze , Hans Sillescu
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