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Valid causal inference in observational studies often requires controlling for confounders. However, in practice measurements of confounders may be noisy, and can lead to biased estimates of causal effects. We show that we can reduce the…

机器学习 · 统计学 2018-06-05 Nathan Kallus , Xiaojie Mao , Madeleine Udell

Causal inference problems have remained an important research topic over the past several decades due to their general applicability in assessing a treatment effect in many different real-world settings. In this paper, we propose two…

统计方法学 · 统计学 2024-01-17 Jingyue Huang , Changbao Wu , Leilei Zeng

Objective: Randomised controlled trials (RCTs) are widely considered as gold standard for assessing the effectiveness of new health interventions. When treatment non-compliance is present in RCTs, the treatment effect in the subgroup of…

应用统计 · 统计学 2025-03-25 Theodosios Papazoglou , Ed Waddingham , Alastair Young

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt…

统计方法学 · 统计学 2025-07-28 Luke Benz , Alexander Levis , Sebastien Haneuse

Modern causal inference methods allow machine learning to be used to weaken parametric modeling assumptions. However, the use of machine learning may result in complications for inference. Doubly-robust cross-fit estimators have been…

统计方法学 · 统计学 2022-03-11 Paul N Zivich , Alexander Breskin

Deep neural networks excel at comprehending complex visual signals, delivering on par or even superior performance to that of human experts. However, ad-hoc visual explanations of model decisions often reveal an alarming level of reliance…

计算机视觉与模式识别 · 计算机科学 2021-05-03 Dong Wang , Yuewei Yang , Chenyang Tao , Zhe Gan , Liqun Chen , Fanjie Kong , Ricardo Henao , Lawrence Carin

Standard causal inference characterizes treatment effect through averages, but the counterfactual distributions could be different in not only the central tendency but also spread and shape. To provide a comprehensive evaluation of…

统计方法学 · 统计学 2022-11-04 Steven G. Xu , Shu Yang , Brian J. Reich

There is intense interest in applying machine learning to problems of causal inference in fields such as healthcare, economics and education. In particular, individual-level causal inference has important applications such as precision…

机器学习 · 统计学 2017-05-17 Uri Shalit , Fredrik D. Johansson , David Sontag

Who should we prioritize for treatment when causal effects cannot be estimated? In practice, organizations often rely on predictive proxies: ads are targeted using purchase probabilities, and retention incentives are allocated using…

机器学习 · 统计学 2025-10-15 Carlos Fernández-Loría , Jorge Loría

Percutaneous coronary interventions (PCIs) are nonsurgical procedures to open blocked blood vessels to the heart, frequently using a catheter to place a stent. The catheter can be inserted into the blood vessels using an artery in the groin…

应用统计 · 统计学 2021-02-25 Samrachana Adhikari , Sherri Rose , Sharon-Lise Normand

Conformal prediction (CP) was developed to provide finite-sample probabilistic prediction guarantees. While CP algorithms are a relatively general-purpose approach to uncertainty quantification, with finite-sample guarantees, they lack…

机器学习 · 统计学 2025-10-08 Jonathan P Williams

Integrating information from multiple data sources can enable more precise, timely, and generalizable decisions. However, it is challenging to make valid causal inferences using observational data from multiple data sources. For example, in…

统计方法学 · 统计学 2023-02-08 Larry Han , Yige Li , Bijan A. Niknam , Jose R. Zubizarreta

Causal inference from observational data often rests on the unverifiable assumption of no unmeasured confounding. Recently, Tchetgen Tchetgen and colleagues have introduced proximal inference to leverage negative control outcomes and…

统计理论 · 数学 2022-08-10 Raluca Cobzaru , Roy Welsch , Stan Finkelstein , Kenney Ng , Zach Shahn

While average treatment effects (ATE) and conditional average treatment effects (CATE) provide valuable population- and subgroup-level summaries, they fail to capture uncertainty at the individual level. For high-stakes decision-making,…

统计方法学 · 统计学 2026-03-31 Juraj Bodik , Yaxuan Huang , Bin Yu

In causal inference with ordinal outcomes, several interpretable estimands are functions of the probability that the potential outcome under one treatment is larger than that under another treatment for the same unit. This probability…

统计方法学 · 统计学 2026-05-13 Peiyu He , Fan Li

The principal stratification has become a popular tool to address a broad class of causal inference questions, particularly in dealing with non-compliance and truncation-by-death problems. The causal effects within principal strata which…

统计方法学 · 统计学 2022-06-20 Shanshan Luo , Wei Li , Wang Miao , Yangbo He

Inferring causal relationships between variable pairs in the observational study is crucial but challenging, due to the presence of unmeasured confounding. While previous methods employed the negative controls to adjust for the confounding…

统计方法学 · 统计学 2025-10-21 Yong Wu , Yanwei Fu , Shouyan Wang , Yizhou Wang , Xinwei Sun

Estimating the conditional average treatment effect (CATE) from observational data plays a crucial role in areas such as e-commerce, healthcare, and economics. Existing studies mainly rely on the strong ignorability assumption that there…

机器学习 · 计算机科学 2025-01-28 Chuan Zhou , Yaxuan Li , Chunyuan Zheng , Haiteng Zhang , Haoxuan Li , Mingming Gong

Difference-in-differences (DiD) is a popular approach to evaluate treatment effects in settings where both pre- and post-treatment measurements of the outcome are available. Despite its popularity, existing methods face important…

统计方法学 · 统计学 2026-03-31 Chan Park , Eric Tchetgen Tchetgen

Proxy variables are commonly used in causal inference when unmeasured confounding exists. While most existing proximal methods assume a unidirectional causal relationship between two primary variables, many social and biological systems…

统计方法学 · 统计学 2025-07-21 Jiaqi Min , Xueyue Zhang , Shanshan Luo