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Neurotransmitter receptor molecules, concentrated in synaptic membrane domains along with scaffolds and other kinds of proteins, are crucial for signal transmission across chemical synapses. In common with other membrane protein domains,…

亚细胞过程 · 定量生物学 2017-05-19 Yiwei Li , Osman Kahraman , Christoph A. Haselwandter

The solution of the path structured multimarginal Schr\"{o}dinger bridge problem (MSBP) is the most-likely measure-valued trajectory consistent with a sequence of observed probability measures or distributional snapshots. We leverage recent…

系统与控制 · 电气工程与系统科学 2023-10-05 Georgiy A. Bondar , Robert Gifford , Linh Thi Xuan Phan , Abhishek Halder

Diffusion Bridge and Flow Matching have both demonstrated compelling empirical performance in transformation between arbitrary distributions. However, there remains confusion about which approach is generally preferable, and the substantial…

计算机视觉与模式识别 · 计算机科学 2025-09-30 Kaizhen Zhu , Mokai Pan , Zhechuan Yu , Jingya Wang , Jingyi Yu , Ye Shi

We propose a novel dataset that has been specifically designed for 3D semantic segmentation of bridges and the domain gap analysis caused by varying sensors. This addresses a critical need in the field of infrastructure inspection and…

计算机视觉与模式识别 · 计算机科学 2026-05-05 Maximilian Kellner , Mariana Ferrandon Cervantes , Yuandong Pan , Ruodan Lu , Ioannis Brilakis , Alexander Reiterer

The deluge of single-cell data obtained by sequencing, imaging and epigenetic markers has led to an increasingly detailed description of cell state. However, it remains challenging to identify how cells transition between different states,…

We consider the problem of simulating diffusion bridges, which are diffusion processes that are conditioned to initialize and terminate at two given states. The simulation of diffusion bridges has applications in diverse scientific fields…

统计计算 · 统计学 2025-06-19 Jeremy Heng , Valentin De Bortoli , Arnaud Doucet , James Thornton

This paper introduces a novel theoretical simplification of the Diffusion Schr\"odinger Bridge (DSB) that facilitates its unification with Score-based Generative Models (SGMs), addressing the limitations of DSB in complex data generation…

机器学习 · 计算机科学 2024-10-30 Zhicong Tang , Tiankai Hang , Shuyang Gu , Dong Chen , Baining Guo

Key features of biological activity can often be captured by transitions between a finite number of semi-stable states that correspond to behaviors or decisions. We present here a broad class of dynamical systems that are ideal for modeling…

动力系统 · 数学 2022-12-14 Megan Morrison , Lai-Sang Young

Diffusion bridge models offer a powerful framework for connecting two data distributions, such as in image restoration and translation. Many existing methods learn this bridge by mimicking the score-matching formulation of standard…

计算机视觉与模式识别 · 计算机科学 2026-05-29 Yurong Gao , Zicheng Zhang , Congying Han , Tiande Guo , Xinmin Qiu

We use non-equilibrium dynamical mean-field theory to demonstrate the existence of a critical interaction in the real-time dynamics of the Hubbard model after an interaction quench. The critical point is characterized by fast thermalization…

强关联电子 · 物理学 2009-09-02 Martin Eckstein , Marcus Kollar , Philipp Werner

Multi-cell cooperation (MCC) is an approach for mitigating inter-cell interference in dense cellular networks. Existing studies on MCC performance typically rely on either over-simplified Wyner-type models or complex system-level…

信息论 · 计算机科学 2012-12-07 Kaibin Huang , Jeffrey G. Andrews

Symmetry breaking has been a central theme in classifying quantum phases and phase transitions. Recently, this concept has been extended to the mixed states of open systems, attracting considerable attention due to the emergence of novel…

强关联电子 · 物理学 2025-10-21 Yuxuan Guo , Sheng Yang , Xue-Jia Yu

Diffusion models (DMs) have become the dominant paradigm of generative modeling in a variety of domains by learning stochastic processes from noise to data. Recently, diffusion denoising bridge models (DDBMs), a new formulation of…

机器学习 · 计算机科学 2024-11-01 Guande He , Kaiwen Zheng , Jianfei Chen , Fan Bao , Jun Zhu

Reconstructing dynamical evolution from limited observations is a fundamental challenge in single-cell biology, where dynamic unbalanced optimal transport provides a principled framework for modeling coupled transport and mass variation.…

机器学习 · 计算机科学 2026-01-29 Xinyu Wang , Ruoyu Wang , Qiangwei Peng , Peijie Zhou , Tiejun Li

We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated…

生物物理 · 物理学 2017-09-01 Roberto de la Cruz , Pilar Guerrero , Fabian Spill , Tomás Alarcón

A central goal in systems biology and drug discovery is to predict the transcriptional response of cells to perturbations. This task is challenging due to the noisy and sparse nature of single-cell measurements, as well as the fact that…

定量方法 · 定量生物学 2026-02-10 Chenglei Yu , Chuanrui Wang , Bangyan Liao , Tailin Wu

We present a new formulation of the correlated electron-ion dynamics (CEID) scheme, which systematically improves Ehrenfest dynamics by including quantum fluctuations around the mean-field atomic trajectories. We show that the method can…

材料科学 · 物理学 2007-12-13 L. Stella , M. Meister , A. J. Fisher , A. P. Horsfield

We present Fractional Diffusion Bridge Models (FDBM), a novel generative diffusion bridge framework driven by an approximation of the rich and non-Markovian fractional Brownian motion (fBM). Real stochastic processes exhibit a degree of…

Stochastic flows of an advective-diffusive nature are ubiquitous in physical sciences. Of particular interest is the problem to reconcile observed marginal distributions with a given prior posed by E. Schrodinger in 1932/32 and known as the…

数学物理 · 物理学 2021-08-09 Yongxin Chen , Tryphon T. Georgiou , Michele Pavon

The nudged elastic band (NEB) method is one of the most widely used techniques for determining minimum-energy reaction pathways and activation barriers between known initial and final states. However, conventional implementations face steep…

计算物理 · 物理学 2025-10-21 Qiuhan Jia , Jiuyang Shi , Jian Sun