相关论文: Gene42: Long-Range Genomic Foundation Model With D…

Large language models (LLMs) have shown growing promise in biomedical research, particularly for knowledge-driven interpretation tasks. However, their ability to reliably reason from gene-level knowledge to functional understanding, a core…

We present a decoder-only Transformer architecture that robustly generalizes to sequence lengths substantially longer than those seen during training. Our model, SWAN-GPT, interleaves layers without positional encodings (NoPE) and…

The rapid evolution of Large Language Models (LLMs) has significantly impacted the field of natural language processing, but their growing complexity raises concerns about resource usage and transparency. Addressing these challenges, we…

Foundation models, first introduced in 2021, refer to large-scale pretrained models (e.g., large language models (LLMs) and vision-language models (VLMs)) that learn from extensive unlabeled datasets through unsupervised methods, enabling…

Pre-trained large language models demonstrate potential in extracting information from DNA sequences, yet adapting to a variety of tasks and data modalities remains a challenge. To address this, we propose DNAGPT, a generalized DNA…

Graphs and networks are a key research tool for a variety of science fields, most notably chemistry, biology, engineering and social sciences. Modeling and generation of graphs with efficient sampling is a key challenge for graphs. In…

Foundation models, such as Large Language Models (LLMs) or Large Vision Models (LVMs), have emerged as one of the most powerful tools in the respective fields. However, unlike text and image data, graph data do not have a definitive…

Designing a unified neural network to efficiently and inherently process sequential data with arbitrary lengths is a central and challenging problem in sequence modeling. The design choices in Transformer, including quadratic complexity and…

As large language models (LLMs) continue to revolutionize AI research, there is a growing interest in building large-scale brain foundation models to advance neuroscience. While most existing brain foundation models are pre-trained on…

Genomic question answering often requires complex reasoning and integration across diverse biomedical sources. GeneGPT addressed this challenge by combining domain-specific APIs with OpenAI's code-davinci-002 large language model to enable…

Proprietary Large Language Models (LLMs) such as GPT-4 and Gemini have demonstrated promising capabilities in clinical text summarization tasks. However, due to patient data privacy concerns and computational costs, many healthcare…

Deep generative models open new avenues for simulating realistic genomic data while preserving privacy and addressing data accessibility constraints. While previous studies have primarily focused on generating gene expression or haplotype…

The evolution of large language models (LLMs) towards applications with ultra-long contexts faces challenges posed by the high computational and memory costs of the Transformer architecture. While existing sparse and linear attention…

The interest in linear complexity models for large language models is on the rise, although their scaling capacity remains uncertain. In this study, we present the scaling laws for linear complexity language models to establish a foundation…

Geometric Attention (GA) specifies an attention layer by four independent inputs: a finite carrier (what indices are addressable), an evidence-kernel rule (how masked proto-scores and a link induce nonnegative weights), a probe family…

We present a novel non attention based architecture for large language models (LLMs) that efficiently handles very long context windows, on the order of hundreds of thousands to potentially millions of tokens. Unlike traditional Transformer…

Facial analysis technologies have recently measured up to the capabilities of expert clinicians in syndrome identification. To date, these technologies could only identify phenotypes of a few diseases, limiting their role in clinical…

This paper introduces AQA-Bench, a novel benchmark to assess the sequential reasoning capabilities of large language models (LLMs) in algorithmic contexts, such as depth-first search (DFS). The key feature of our evaluation benchmark lies…

Medical Foundation Models (MFMs), trained on large-scale datasets, have demonstrated superior performance across various tasks. However, these models still struggle with domain gaps in practical applications. Specifically, even after…

Identifying transcription factor binding sites (TFBS) is crucial for understanding gene regulation, as these sites enable transcription factors (TFs) to bind to DNA and modulate gene expression. Despite advances in high-throughput…