相关论文: Gene42: Long-Range Genomic Foundation Model With D…

Retrieval-augmented generation (RAG) has proven effective in integrating knowledge into large language models (LLMs). However, conventional RAGs struggle to capture complex relationships between pieces of knowledge, limiting their…

We propose that small pretrained foundational generative language models with millions of parameters can be utilized as a general learning framework for sequence-based tasks. Our proposal overcomes the computational resource, skill set, and…

This paper introduces a novel approach to enhance the capabilities of Large Language Models (LLMs) in processing and understanding extensive text sequences, a critical aspect in applications requiring deep comprehension and synthesis of…

We report a flexible language-model based deep learning strategy, applied here to solve complex forward and inverse problems in protein modeling, based on an attention neural network that integrates transformer and graph convolutional…

One of the prominent issues stifling the current generation of large language models is their limited context length. Recent proprietary models such as GPT-4 and Claude 2 have introduced longer context lengths, 8k/32k and 100k,…

Sequencing technologies are prone to errors, making error correction (EC) necessary for downstream applications. EC tools need to be manually configured for optimal performance. We find that the optimal parameters (e.g., k-mer size) are…

Graph foundation models (GFM) aim to acquire transferable knowledge by pre-training on diverse graphs, which can be adapted to various downstream tasks. However, domain shift in graphs is inherently two-dimensional: graphs differ not only…

While Transformers have revolutionized deep learning, their quadratic attention complexity hinders their ability to process infinitely long inputs. We propose Feedback Attention Memory (FAM), a novel Transformer architecture that leverages…

Attention mechanisms underpin the success of large language models (LLMs), yet their substantial computational and memory overhead poses challenges for optimizing efficiency and performance. A critical bottleneck arises as KV cache and…

We report a flexible multi-modal mechanics language model, MeLM, applied to solve various nonlinear forward and inverse problems, that can deal with a set of instructions, numbers and microstructure data. The framework is applied to various…

Long-context understanding is crucial for many NLP applications, yet transformers struggle with efficiency due to the quadratic complexity of self-attention. Sparse attention methods alleviate this cost but often impose static, predefined…

Gene expression data represents a unique challenge in predictive model building, because of the small number of samples $(n)$ compared to the huge amount of features $(p)$. This "$n<<p$" property has hampered application of deep learning…

Scaling context length is reshaping large-model development, yet full-attention Transformers suffer from prohibitive computation and inference bottlenecks at long sequences. A key challenge is to design foundation models that maintain…

Large Language Models (LLMs) have consistently showcased remarkable generalization capabilities when applied to various language tasks. Nonetheless, harnessing the full potential of LLMs for Radiology Report Generation (R2Gen) still…

Early detection of Alzheimer's disease (AD) requires models capable of integrating macro-scale neuroanatomical alterations with micro-scale genetic susceptibility, yet existing multimodal approaches struggle to align these heterogeneous…

Long-term biomolecular dynamics are critical for understanding key evolutionary transformations in molecular systems. However, capturing these processes requires extended simulation timescales that often exceed the practical limits of…

Background: Several studies show that large language models (LLMs) struggle with phenotype-driven gene prioritization for rare diseases. These studies typically use Human Phenotype Ontology (HPO) terms to prompt foundation models like GPT…

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Self-attention has recently been adopted for a wide range of sequence modeling problems. Despite its effectiveness, self-attention suffers from quadratic compute and memory requirements with respect to sequence length. Successful approaches…

The Transformer model is widely successful on many natural language processing tasks. However, the quadratic complexity of self-attention limit its application on long text. In this paper, adopting a fine-to-coarse attention mechanism on…