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Stochastic Galerkin finite element discretizations of partial differential equations with coefficients characterized by arbitrary distributions lead, in general, to fully block dense linear systems. We propose two novel strategies for…

数值分析 · 数学 2014-07-31 Bedřich Sousedík , Roger G. Ghanem

An acoustic wave propagation problem with a log normal random field approximation for wave speed is solved using a sampling-free intrusive stochastic Galerkin approach. The stochastic partial differential equation with the inputs and…

计算工程、金融与科学 · 计算机科学 2026-01-23 Sudhi Sharma Padillath Vasudevan

Computer-based simulations of non-invasive cardiac electrical outputs, such as electrocardiograms and body surface potential maps, usually entail severe computational costs due to the need of capturing fine-scale processes and to the…

数值分析 · 数学 2023-08-09 Elena Zappon , Andrea Manzoni , Alfio Quarteroni

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology…

图像与视频处理 · 电气工程与系统科学 2023-08-21 Xiaoxiao He , Chaowei Tan , Ligong Han , Bo Liu , Leon Axel , Kang Li , Dimitris N. Metaxas

In this paper we propose a novel coupled poroelasticity-diffusion model for the formation of extracellular oedema and infectious myocarditis valid in large deformations, manifested as an interaction between interstitial flow and the…

Computational modeling of multicellular systems may aid in untangling cellular dynamics and emergent properties of biological cell populations. A key challenge is to balance the level of model detail and the computational efficiency, while…

定量方法 · 定量生物学 2026-04-22 Erik Blom , Stefan Engblom

The recent improvements in cryo-electron microscopy (cryo-EM) in the past few years are now allowing to observe molecular complexes at atomic resolution. As a consequence, numerous structures derived from cryo-EM are now available in the…

生物大分子 · 定量生物学 2020-05-04 Mikael Trellet , Gydo van Zundert , Alexandre M. J. J. Bonvin

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the formulation and numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential,…

计算物理 · 物理学 2021-01-27 Stefania Fresca , Andrea Manzoni , Luca Dedè , Alfio Quarteroni

This paper aims to address two issues of integral equations for the scattering of time-harmonic electromagnetic waves by a perfect electric conductor with Lipschitz continuous boundary: ill-conditioned {boundary element Galerkin matrices}…

数值分析 · 数学 2024-10-29 Van Chien Le , Kristof Cools

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

机器学习 · 计算机科学 2026-03-31 Qian Shao , Bang Du , Zepeng Li , Qiyuan Chen , Jiahe Chen , Hongxia Xu , Jimeng Sun , Jian Wu , Jintai Chen

The high prevalence of cardiovascular diseases (CVDs) calls for accessible and cost-effective continuous cardiac monitoring tools. Despite Electrocardiography (ECG) being the gold standard, continuous monitoring remains a challenge, leading…

信号处理 · 电气工程与系统科学 2023-12-29 Debaditya Shome , Pritam Sarkar , Ali Etemad

In this paper, we develop subspace correction preconditioners for discontinuous Galerkin (DG) discretizations of elliptic problems with $hp$-refinement. These preconditioners are based on the decomposition of the DG finite element space…

数值分析 · 数学 2022-11-11 Will Pazner , Tzanio Kolev

Electrical conduction among cardiac tissue is commonly modeled with partial differential equations, i.e., reaction-diffusion equation, where the reaction term describes cellular stimulation and diffusion term describes electrical…

机器学习 · 计算机科学 2021-09-21 Xinyu Zhao , Hao Yan , Zhiyong Hu , Dongping Du

We analyse a class of nonoverlapping domain decomposition preconditioners for nonsymmetric linear systems arising from discontinuous Galerkin finite element approximation of fully nonlinear Hamilton--Jacobi--Bellman (HJB) partial…

数值分析 · 数学 2024-12-06 Iain Smears

Bayesian learning in undirected graphical models|computing posterior distributions over parameters and predictive quantities is exceptionally difficult. We conjecture that for general undirected models, there are no tractable MCMC (Markov…

机器学习 · 计算机科学 2012-07-19 Iain Murray , Zoubin Ghahramani

Heart failure is one of the most common causes of death in the western world. Many heart problems are linked to disturbances in cardiac electrical activity, such as wave re-entry caused by ischaemia. In terms of mathematical modelling, the…

Cardiac arrhythmias are a major cause of morbidity and mortality increasing the risk of stroke, heart failure, and sudden cardiac death. Imageless electrocardiographic imaging (ECGI) provides a non invasive alternative to electrical mapping…

Intricating cardiac complexities are the primary factor associated with healthcare costs and the highest cause of death rate in the world. However, preventive measures like the early detection of cardiac anomalies can prevent severe…

机器学习 · 计算机科学 2019-04-18 Asim Darwaish , Farid Naït-Abdesselam , Ashfaq Khokhar

The aim of this paper is to propose a novel methodology to deal with micro-structural boundary conditions for the analysis of granular materials. The response of the granular assembly is modelled through the discrete element method (DEM),…

软凝聚态物质 · 物理学 2017-02-27 J. Liu , E. Bosco , A. S. J. Suiker

In this paper, we consider the balancing domain decomposition by constraints (BDDC) algorithm with adaptive coarse spaces for a class of stochastic elliptic problems. The key ingredient in the construction of the coarse space is the…

数值分析 · 数学 2021-04-20 Eric Chung , Hyea Hyun Kim , Ming Fai Lam , Lina Zhao