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The difference-in-differences (DiD) design is a quasi-experimental method for estimating treatment effects. In staggered DiD with multiple treatment groups and periods, estimation based on the two-way fixed effects model yields negative…

统计方法学 · 统计学 2026-03-05 Yuhao Deng , Le Kang

Since survival data occur over time, often important covariates that we wish to consider also change over time. Such covariates are referred as time-dependent covariates. Quantile regression offers flexible modeling of survival data by…

统计方法学 · 统计学 2014-05-01 Malka Gorfine , Yair Goldberg , Yaacov Ritov

Randomized clinical trials are considered the gold standard for informing treatment guidelines, but results may not generalize to real-world populations. Generalizability is hindered by distributional differences in baseline covariates and…

统计方法学 · 统计学 2025-06-03 Rachael K. Ross , Ivan Diaz , Amy J. Pitts , Elizabeth A. Stuart , Kara E. Rudolph

In survival analysis, regression models are used to understand the effects of explanatory variables (e.g., age, sex, weight, etc.) to the survival probability. However, for sensitive survival data such as medical data, there are serious…

机器学习 · 计算机科学 2017-08-28 Thông T. Nguyên , Siu Cheung Hui

In observational studies, covariate imbalance generates confounding, resulting in biased comparisons. Although propensity score-based weighting approaches facilitate unconfounded group comparisons for implicit target populations, existing…

统计方法学 · 统计学 2023-07-03 Subharup Guha , David C. Christiani , Yi Li

We revisit the problem of estimating the local average treatment effect (LATE) and the local average treatment effect on the treated (LATT) when control variables are available, either to render the instrumental variable (IV) suitably…

计量经济学 · 经济学 2022-11-16 Tymon Słoczyński , S. Derya Uysal , Jeffrey M. Wooldridge

Leveraging external controls -- relevant individual patient data under control from external trials or real-world data -- has the potential to reduce the cost of randomized controlled trials (RCTs) while increasing the proportion of trial…

统计方法学 · 统计学 2022-07-13 Yanyao Yi , Ying Zhang , Yu Du , Ting Ye

The restricted mean survival time is a clinically easy-to-interpret measure that does not require any assumption of proportional hazards. We focus on two ways to directly model the survival time and adjust the covariates. One is to…

统计方法学 · 统计学 2022-11-03 Keisuke Hanada , Junji Moriya , Masahiro Kojima

Proximal causal learning is a promising framework for identifying the causal effect under the existence of unmeasured confounders. Within this framework, the doubly robust (DR) estimator was derived and has shown its effectiveness in…

统计方法学 · 统计学 2024-03-12 Yong Wu , Yanwei Fu , Shouyan Wang , Xinwei Sun

In recommendation systems (RS), user behavior data is observational rather than experimental, resulting in widespread bias in the data. Consequently, tackling bias has emerged as a major challenge in the field of recommendation systems.…

信息检索 · 计算机科学 2023-08-21 ZiJie Song , JiaWei Chen , Sheng Zhou , QiHao Shi , Yan Feng , Chun Chen , Can Wang

Massive sized survival datasets are becoming increasingly prevalent with the development of the healthcare industry. Such datasets pose computational challenges unprecedented in traditional survival analysis use-cases. A popular way for…

统计方法学 · 统计学 2023-05-09 Nir Keret , Malka Gorfine

We present a general framework for using existing data to estimate the efficiency gain from using a covariate-adjusted estimator of a marginal treatment effect in a future randomized trial. We describe conditions under which it is possible…

统计方法学 · 统计学 2021-05-03 Xiudi Li , Sijia Li , Alex Luedtke

We propose a doubly robust estimator for the average treatment effect in high dimensional low sample size observational studies, where contamination and model misspecification pose serious inferential challenges. The estimator combines…

统计方法学 · 统计学 2025-11-04 Byeonghee Lee , Sangwook Kang , Ju-Hyun Park , Saebom Jeon , Joonsung Kang

There is a surge in medical follow-up studies that include longitudinal covariates in the modeling of survival data. So far, the focus has been largely on right-censored survival data. We consider survival data that are subject to both left…

统计理论 · 数学 2012-09-25 Yu-Ru Su , Jane-Ling Wang

We consider the estimation of treatment effects in settings when multiple treatments are assigned over time and treatments can have a causal effect on future outcomes or the state of the treated unit. We propose an extension of the…

计量经济学 · 经济学 2021-06-18 Greg Lewis , Vasilis Syrgkanis

Precision medicine is a rapidly expanding area of health research wherein patient level information is used to inform treatment decisions. A statistical framework helps to formalize the individualization of treatment decisions that…

统计方法学 · 统计学 2021-12-23 Coraline Danieli , Erica Moodie

Educational policymakers often lack data on student outcomes where standardized tests were not administered. Machine learning can predict unobserved outcomes in target populations using source population data. However, covariate…

This work bridges the gap between staggered adoption designs and survival analysis to estimate causal effects in settings with time-varying treatments, addressing a fundamental challenge in medical research exemplified by the Stanford Heart…

统计方法学 · 统计学 2025-03-04 Xiang Meng , Iavor Bojinov

Increasingly, medical research is dependent on data collected for non-research purposes, such as electronic health records data (EHR). EHR data and other large databases can be prone to measurement error in key exposures, and unadjusted…

统计方法学 · 统计学 2020-05-13 Kyunghee Han , Thomas Lumley , Bryan E. Shepherd , Pamela A. Shaw

When data are right-censored, i.e. some outcomes are missing due to a limited period of observation, survival analysis can compute the "time to event". Multiple classes of outcomes lead to a classification variant: predicting the most…

人工智能 · 计算机科学 2024-06-21 Julie Alberge , Vincent Maladière , Olivier Grisel , Judith Abécassis , Gaël Varoquaux