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We develop a mathematical framework to define an optimal individualized treatment rule (ITR) within the context of prioritized outcomes in a randomized controlled trial. Our optimality criterion is based on the framework of generalized…

统计方法学 · 统计学 2025-06-17 François Petit , Gérard Biau , Raphaël Porcher

What proportion of treated units actually benefited from an experimental intervention? What is the median or the largest individual treatment effect? This paper develops methods for answering such questions about the distribution of…

统计方法学 · 统计学 2026-05-11 David Kim , Yongchang Su , Jake Bowers , Xinran Li

Network meta-analysis is a powerful tool to synthesize evidence from independent studies and compare multiple treatments simultaneously. A critical task of performing a network meta-analysis is to offer ranks of all available treatment…

统计方法学 · 统计学 2022-07-15 Andrés F. Barrientos , Garritt L. Page , Lifeng Lin

Multi-label ranking maps instances to a ranked set of predicted labels from multiple possible classes. The ranking approach for multi-label learning problems received attention for its success in multi-label classification, with one of the…

计算机视觉与模式识别 · 计算机科学 2022-12-09 Emine Dari , V. Bugra Yesilkaynak , Alican Mertan , Gozde Unal

In many medical and business applications, researchers are interested in estimating individualized treatment effects using data from a randomized experiment. For example in medical applications, doctors learn the treatment effects from…

统计方法学 · 统计学 2022-03-01 Kevin Wu Han , Han Wu

We study the problem of a decision maker who must provide the best possible treatment recommendation based on an experiment. The desirability of the outcome distribution resulting from the policy recommendation is measured through a…

计量经济学 · 经济学 2022-04-06 Anders Bredahl Kock , David Preinerstorfer , Bezirgen Veliyev

We propose a novel personalized concept for the optimal treatment selection for a situation where the response is a multivariate vector, that could contain right-censored variables such as survival time. The proposed method can be applied…

统计方法学 · 统计学 2022-10-03 Chathura Siriwardhana , K. B. Kulasekera , Somnath Datta

Clinical trials often involve the assessment of multiple endpoints to comprehensively evaluate the efficacy and safety of interventions. In the work, we consider a global nonparametric testing procedure based on multivariate rank for the…

统计方法学 · 统计学 2023-06-29 Kexuan Li , Lingli Yang , Shaofei Zhao , Susie Sinks , Luan Lin , Peng Sun

A treatment regime is a function that maps individual patient information to a recommended treatment, hence explicitly incorporating the heterogeneity in need for treatment across individuals. Patient responses are dichotomous and can be…

机器学习 · 统计学 2016-07-07 Yingfei Wang , Warren Powell

Background: Comparative effectiveness research using network meta-analysis can present a hierarchy of competing treatments, from the least to most preferable option. However, the research question associated with the hierarchy of multiple…

We study the design of experiments with multiple treatment levels, a setting common in clinical trials and online A/B/n testing. Unlike single-treatment studies, practical analyses of multi-treatment experiments typically first select a…

统计方法学 · 统计学 2025-10-07 Jiachen Xu , Jian Qian , Zijun Gao

We propose new, optimal methods for analyzing randomized trials, when it is suspected that treatment effects may differ in two predefined subpopulations. Such sub-populations could be defined by a biomarker or risk factor measured at…

统计方法学 · 统计学 2016-11-26 Michael Rosenblum , Han Liu , and En-Hsu Yen

One primary goal of precision medicine is to estimate the individualized treatment rules (ITRs) that optimize patients' health outcomes based on individual characteristics. Health studies with multiple treatments are commonly seen in…

统计方法学 · 统计学 2025-05-07 Xuqiao Li , Qiuyan Zhou , Ying Wu , Ying Yan

For mental disorders, patients' underlying mental states are non-observed latent constructs which have to be inferred from observed multi-domain measurements such as diagnostic symptoms and patient functioning scores. Additionally,…

机器学习 · 计算机科学 2020-11-03 Yuan Chen , Donglin Zeng , Tianchen Xu , Yuanjia Wang

A treatment regime is a deterministic function that dictates personalized treatment based on patients' individual prognostic information. There is a fast-growing interest in finding optimal treatment regimes to maximize expected long-term…

统计理论 · 数学 2016-11-25 Runchao Jiang , Wenbin Lu , Rui Song , Marie Davidian

We study the design of multi-armed parallel group clinical trials to estimate personalized treatment rules that identify the best treatment for a given patient with given covariates. Assuming that the outcomes in each treatment arm are…

统计理论 · 数学 2022-07-13 David Azriel , Yosef Rinott , Martin Posch

Randomized experimentation (also known as A/B testing or bucket testing) is widely used in the internet industry to measure the metric impact obtained by different treatment variants. A/B tests identify the treatment variant showing the…

统计方法学 · 统计学 2020-12-23 Ye Tu , Kinjal Basu , Cyrus DiCiccio , Romil Bansal , Preetam Nandy , Padmini Jaikumar , Shaunak Chatterjee

A common way of doing algorithm selection is to train a machine learning model and predict the best algorithm from a portfolio to solve a particular problem. While this method has been highly successful, choosing only a single algorithm has…

人工智能 · 计算机科学 2013-11-19 Lars Kotthoff

After the phenomenal success of the PageRank algorithm, many researchers have extended the PageRank approach to ranking graphs with richer structures beside the simple linkage structure. In some scenarios we have to deal with…

数值分析 · 数学 2018-11-15 Gianna M. Del Corso , Francesco Romani

Efficiently allocating treatments with a budget constraint constitutes an important challenge across various domains. In marketing, for example, the use of promotions to target potential customers and boost conversions is limited by the…

机器学习 · 计算机科学 2024-05-06 Toon Vanderschueren , Wouter Verbeke , Felipe Moraes , Hugo Manuel Proença
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