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The piecewise exponential model is a flexible non-parametric approach for time-to-event data, but extrapolation beyond final observation times typically relies on random walk priors and deterministic knot locations, resulting in unrealistic…

统计方法学 · 统计学 2025-05-12 Luke Hardcastle , Samuel Livingstone , Gianluca Baio

Prognostic models in survival analysis are aimed at understanding the relationship between patients' covariates and the distribution of survival time. Traditionally, semi-parametric models, such as the Cox model, have been assumed. These…

机器学习 · 统计学 2020-11-06 Denise Rava , Jelena Bradic

Identifying and characterizing relationships between treatments, exposures, or other covariates and time-to-event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi-center clinical…

统计方法学 · 统计学 2025-04-02 Hillary M. Heiling , Naim U. Rashid , Quefeng Li , Xianlu L. Peng , Jen Jen Yeh

In this paper, a family of neural network-based survival models is presented. The models are specified based on piecewise definitions of the hazard function and the density function on a partitioning of the time; both constant and linear…

机器学习 · 统计学 2024-03-28 Olov Holmer , Erik Frisk , Mattias Krysander

We propose a versatile framework for survival analysis that combines advanced concepts from statistics with deep learning. The presented framework is based on piecewise exponential models and thereby supports various survival tasks, such as…

Survival models are a popular tool for the analysis of time to event data with applications in medicine, engineering, economics, and many more. Advances like the Cox proportional hazard model have enabled researchers to better describe…

机器学习 · 统计学 2021-02-16 Stefan Groha , Sebastian M Schmon , Alexander Gusev

Proportional hazards (PH), proportional odds (PO) and accelerated failure time (AFT) models have been widely used to deal with survival data in different fields of knowledge. Despite their popularity, such models are not suitable to handle…

统计方法学 · 统计学 2019-10-08 Fabio N. Demarqui , Vinicius D. Mayrink

Survival models capture the relationship between an accumulating hazard and the occurrence of a singular event stimulated by that accumulation. When the model for the hazard is sufficiently flexible survival models can accommodate a wide…

统计方法学 · 统计学 2024-03-04 Michael Betancourt

Survival models are used to analyze time-to-event data in a variety of disciplines. Proportional hazard models provide interpretable parameter estimates, but proportional hazards assumptions are not always appropriate. Non-parametric models…

统计方法学 · 统计学 2022-07-08 Richard D. Payne , Nilabja Guha , Bani K. Mallick

We introduce an additive stochastic mortality model which allows joint modelling and forecasting of underlying death causes. Parameter families for mortality trends can be chosen freely. As model settings become high dimensional, Markov…

风险管理 · 定量金融 2017-05-02 Jonas Hirz , Uwe Schmock , Pavel V. Shevchenko

A class of multivariate mixed survival models for continuous and discrete time with a complex covariance structure is introduced in a context of quantitative genetic applications. The methods introduced can be used in many applications in…

应用统计 · 统计学 2014-05-06 Rafael Pimentel Maia , Per Madsen , Rodrigo Labouriau

Bayesian nonparametric inferential procedures based on Markov chain Monte Carlo marginal methods typically yield point estimates in the form of posterior expectations. Though very useful and easy to implement in a variety of statistical…

统计理论 · 数学 2016-05-04 Julyan Arbel , Antonio Lijoi , Bernardo Nipoti

The proportional hazards (PH), proportional odds (PO) and accelerated failure time (AFT) models have been widely used in different applications of survival analysis. Despite their popularity, these models are not suitable to handle lifetime…

统计方法学 · 统计学 2019-10-11 Fabio N. Demarqui , Vinicius D. Mayrink , Sujit K. Ghosh

Survival analysis (SA) is an active field of research that is concerned with time-to-event outcomes and is prevalent in many domains, particularly biomedical applications. Despite its importance, SA remains challenging due to small-scale…

机器学习 · 统计学 2022-02-16 Philipp Kopper , Simon Wiegrebe , Bernd Bischl , Andreas Bender , David Rügamer

We consider a parametric modelling approach for survival data where covariates are allowed to enter the model through multiple distributional parameters, i.e., scale and shape. This is in contrast with the standard convention of having a…

统计方法学 · 统计学 2021-11-17 Fatima-Zahra Jaouimaa , Il Do Ha , Kevin Burke

Mathematical models are essential for understanding and making predictions about systems arising in nature and engineering. Yet, mathematical models are a simplification of true phenomena, thus making predictions subject to uncertainty.…

数值分析 · 数学 2023-03-03 Mark Hobbs , Hussein Rappel , Tim Dodwell

The hazard function is central to the formulation of commonly used survival regression models such as the proportional hazards and accelerated failure time models. However, these models rely on a shared baseline hazard, which, when…

统计方法学 · 统计学 2025-12-19 J. A. Christen , F. J. Rubio

Parametric assumptions such as exponential distribution are commonly used in clinical trial design and analysis. However, violation of distribution assumptions can introduce biases in sample size and power calculations. Piecewise…

统计方法学 · 统计学 2026-05-14 Tianchen Xu , Rachael Wen , Wen Zhang

Excess hazard modeling is one of the main tools in population-based cancer survival research. Indeed, this setting allows for direct modeling of the survival due to cancer even in the absence of reliable information on the cause of death,…

统计方法学 · 统计学 2022-04-12 A. Eletti , G. Marra , M. Quaresma , R. Radice , F. J. Rubio

We study the multiplicative hazards model with intermittently observed longitudinal covariates and time-varying coefficients. For such models, the existing ad hoc approach, such as the last value carried forward, is biased. We propose a…

统计方法学 · 统计学 2025-03-13 Zhuowei Sun , Hongyuan Cao
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