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Multi-state models provide an extension of the usual survival/event-history analysis setting. In the medical domain, multi-state models give the possibility of further investigating intermediate events such as relapse and remission. In this…

统计方法学 · 统计学 2021-06-24 D. Manevski , H. Putter , M. Pohar Perme , E. F. Bonneville , J. Schetelig , L. C. de Wreede

To better understand effects of exposure to food allergens, food challenge studies are designed to slowly increase the dose of an allergen delivered to allergic individuals until an objective reaction occurs. These dose-to-failure studies…

应用统计 · 统计学 2019-08-30 Matthew W. Wheeler , Joost Westerhout , Joe L. Baumert , Benjamin C. Remington

Bayesian synthetic likelihood (BSL) is a popular method for estimating the parameter posterior distribution for complex statistical models and stochastic processes that possess a computationally intractable likelihood function. Instead of…

统计计算 · 统计学 2019-07-26 Ziwen An , Leah F South , Christopher Drovandi

Multi-regional clinical trials (MRCTs) play an increasingly crucial role in global pharmaceutical development by expediting data gathering and regulatory approval across diverse patient populations. However, differences in recruitment…

统计方法学 · 统计学 2024-04-15 Kaiyuan Hua , Hwanhee Hong , Xiaofei Wang

A robust estimator for a wide family of mixtures of linear regression is presented. Robustness is based on the joint adoption of the Cluster Weighted Model and of an estimator based on trimming and restrictions. The selected model provides…

统计方法学 · 统计学 2015-02-05 L. A. Garcia-Escudero , A. Gordaliza , F. Greselin , S. Ingrassia , A. Mayo-Iscar

In this paper, we develop two fully parametric quantile regression models, based on power Johnson SB distribution Cancho et al. (2020), for modeling unit interval response at different quantiles. In particular, the conditional distribution…

We introduce a numerically tractable formulation of Bayesian joint models for longitudinal and survival data. The longitudinal process is modelled using generalised linear mixed models, while the survival process is modelled using a…

统计方法学 · 统计学 2021-04-23 Danilo Alvares , Francisco Javier Rubio

When constructing parametric models to predict the cost of future claims, several important details have to be taken into account: (i) models should be designed to accommodate deductibles, policy limits, and coinsurance factors, (ii)…

统计方法学 · 统计学 2024-02-22 Chudamani Poudyal , Qian Zhao , Vytaras Brazauskas

Survival analysis aims to estimate a time-to-event distribution from data with censored observations. Many existing methods either impose structural assumptions on the hazard function or discretize the time axis, which may limit flexibility…

机器学习 · 计算机科学 2026-05-22 Stanislav R. Kirpichenko , Andrei V. Konstantinov , Lev V. Utkin

In cancer epidemiology, the \emph{relative survival framework} is used to quantify the hazard associated with cancer by comparing the all-cause mortality hazard in cancer patients to that of the general population. This framework assumes…

应用统计 · 统计学 2024-11-05 Piyali Basak , Antonio R. Linero , Camille Maringe , F. Javier Rubio

The mean residual life function is a key functional for a survival distribution. It has a practically useful interpretation as the expected remaining lifetime given survival up to a particular time point, and it also characterizes the…

统计方法学 · 统计学 2018-10-11 Valerie Poynor , Athanasios Kottas

Given additional distributional information in the form of moment restrictions, kernel density and distribution function estimators with implied generalised empirical likelihood probabilities as weights achieve a reduction in variance due…

统计方法学 · 统计学 2019-10-08 Vitaliy Oryshchenko , Richard J. Smith

Bayesian inference for survival regression modeling offers numerous advantages, especially for decision-making and external data borrowing, but demands the specification of the baseline hazard function, which may be a challenging task. We…

Over the last five decades, we have seen strong methodological advances in survival analysis, mainly in two separate strands: One strand is based on a parametric approach that assumes some response distribution. More prominent, however, is…

统计方法学 · 统计学 2025-03-25 Sandra Siegfried , Bálint Tamási , Torsten Hothorn

This paper deals with Bayesian estimations of scale parameter of the exponential distribution based on upper record range (Rn). This has been done in two steps; point and interval. In the first step the quadratic, squared error and absolute…

概率论 · 数学 2013-06-26 P. Nasiri , S. Hosseini , M. Yarmohammadi , F. Hatami

We propose a highly flexible distributional copula regression model for bivariate time-to-event data in the presence of right-censoring. The joint survival function of the response is constructed using parametric copulas, allowing for a…

统计方法学 · 统计学 2024-12-23 Guillermo Briseno-Sanchez , Nadja Klein , Andreas Groll , Andreas Mayr

In this paper, we focus on the parametric inference based on the Tampered Random Variable (TRV) model for simple step-stress life testing (SSLT) using Type-II censored data. The baseline lifetime of the experimental units, under normal…

统计方法学 · 统计学 2023-02-20 Subhankar Dutta , Farha Sultana , Suchandan Kayal

We introduce a novel and scalable Bayesian framework for multivariate-density-density regression (DDR), designed to model relationships between multivariate distributions. Our approach addresses the critical issue of distributions residing…

统计方法学 · 统计学 2025-09-24 Khai Nguyen , Yang Ni , Peter Mueller

Bayesian nonparametrics are a class of probabilistic models in which the model size is inferred from data. A recently developed methodology in this field is small-variance asymptotic analysis, a mathematical technique for deriving learning…

机器学习 · 统计学 2017-07-27 Trevor Campbell , Brian Kulis , Jonathan How

Recurrent binary outcomes within individuals, such as hospital readmissions, often reflect latent risk processes that evolve over time. Conventional methods like generalized linear mixed models and generalized estimating equations estimate…

统计方法学 · 统计学 2026-02-24 Niloofar Ramezani , Lori P. Selby , Pascal Nitiema , Jeffrey R. Wilson