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Mathematical models can provide quantitative insight into immunoreceptor signaling, but require parameterization and uncertainty quantification before making reliable predictions. We review currently available methods and software tools to…

定量方法 · 定量生物学 2019-06-28 Eshan D. Mitra , William S. Hlavacek

Model updating of engineering systems inevitably involves handling both aleatory or inherent randomness and epistemic uncertainties or uncertainities arising from a lack of knowledge or information about the system. Addressing these…

应用统计 · 统计学 2025-05-27 Sangwon Lee , Taro Yaoyama , Masaru Kitahara , Tatsuya Itoi

ML models have errors when used for predictions. The errors are unknown but can be quantified by model uncertainty. When multiple ML models are trained using the same training points, their model uncertainties may be statistically…

机器学习 · 统计学 2025-09-23 Xiaoping Du

In this work, we present methodologies for the quantification of confidence in bottom-up coarse-grained models for molecular and macromolecular systems. Coarse-graining methods have been extensively used in the past decades in order to…

This paper proposes a new non-parametric bootstrap method to quantify the uncertainty of average treatment effect estimate for the treated from matching estimators. More specifically, it seeks to quantify the uncertainty associated with the…

统计方法学 · 统计学 2024-08-21 Jing Li

Methods for model parameter estimation, uncertainty quantification and experimental design are summarized in this paper. They are based on the generalized least squares estimator and different approximations of its covariance matrix using…

应用统计 · 统计学 2019-12-17 Joscha Reimer

Quantifying uncertainty and updating reliability are essential for ensuring the safety and performance of engineering systems. This study develops a hierarchical Bayesian modeling (HBM) framework to quantify uncertainty and update…

统计方法学 · 统计学 2024-12-31 Xinyu Jia , Weinan Hou , Costas Papadimitriou

This paper deals with nonlinear mechanics of an elevator brake system subjected to uncertainties. A deterministic model that relates the braking force with uncertain parameters is deduced from mechanical equilibrium conditions. In order to…

计算工程、金融与科学 · 计算机科学 2024-09-30 Piotr Wolszczak , Pawel Lonkwic , Americo Cunha , Grzegorz Litak , Szymon Molski

Machine learning models have emerged as a very effective strategy to sidestep time-consuming electronic-structure calculations, enabling accurate simulations of greater size, time scale and complexity. Given the interpolative nature of…

Parameter inference and uncertainty quantification are important steps when relating mathematical models to real-world observations, and when estimating uncertainty in model predictions. However, methods for doing this can be…

定量方法 · 定量生物学 2025-08-27 Michael J. Plank , Matthew J. Simpson

In the presence of modeling errors, the mainstream Bayesian methods seldom give a realistic account of uncertainties as they commonly underestimate the inherent variability of parameters. This problem is not due to any misconception in the…

应用统计 · 统计学 2020-05-19 Omid Sedehi , Costas Papadimitriou , Lambros S. Katafygiotis

We study an optimization-based approach to construct statistically accurate confidence intervals for simulation performance measures under nonparametric input uncertainty. This approach computes confidence bounds from simulation runs driven…

统计方法学 · 统计学 2019-02-14 Henry Lam , Huajie Qian

Constitutive model discovery refers to the task of identifying an appropriate model structure, usually from a predefined model library, while simultaneously inferring its material parameters. The data used for model discovery are measured…

机器学习 · 计算机科学 2026-01-27 David Anton , Henning Wessels , Ulrich Römer , Alexander Henkes , Jorge-Humberto Urrea-Quintero

Stochastic simulation is widely used to study complex systems composed of various interconnected subprocesses, such as input processes, routing and control logic, optimization routines, and data-driven decision modules. In practice, these…

统计计算 · 统计学 2026-02-19 Mohammadmahdi Ghasemloo , David J. Eckman , Yaxian Li

Despite the popularity of Convolutional Neural Networks (CNN), the problem of uncertainty quantification (UQ) of CNN has been largely overlooked. Lack of efficient UQ tools severely limits the application of CNN in certain areas, such as…

机器学习 · 计算机科学 2026-04-15 Hongfei Du , Emre Barut , Fang Jin

We propose using the frequency-domain bootstrap (FDB) to estimate errors of modeling parameters when the modeling error is itself a major source of uncertainty. Unlike the usual bootstrap or the simple $\chi^2$ analysis, the FDB can take…

核理论 · 物理学 2017-12-27 G. F. Bertsch , Derek Bingham

Language models can learn a range of capabilities from unsupervised training on text corpora. However, to solve a particular problem (such as text summarization) it is typically necessary to fine-tune them on a task-specific dataset. It is…

计算与语言 · 计算机科学 2022-03-16 Adam Gleave , Geoffrey Irving

Uncertainty propagation in high-dimensional nonlinear dynamic structural systems is pivotal in state-of-the-art performance-based design and risk assessment, where uncertainties from both excitations and structures, i.e., the aleatoric…

机器学习 · 计算机科学 2026-04-03 Manisha Sapkota , Min Li , Bowei Li

This paper investigates the (in)-consistency of various bootstrap methods for making inference on a change-point in time in the Cox model with right censored survival data. A criterion is established for the consistency of any bootstrap…

统计方法学 · 统计学 2013-08-01 Gongjun Xu , Bodhisattva Sen , Zhiliang Ying

The bootstrap is a method for estimating the distribution of an estimator or test statistic by re-sampling the data or a model estimated from the data. Under conditions that hold in a wide variety of econometric applications, the bootstrap…

计量经济学 · 经济学 2018-09-12 Joel L. Horowitz