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Highly-directional image artifacts such as ion mill curtaining, mechanical scratches, or image striping from beam instability degrade the interpretability of micrographs. These unwanted, aperiodic features extend the image along a primary…

计算机视觉与模式识别 · 计算机科学 2019-06-26 Jonathan Schwartz , Yi Jiang , Yongjie Wang , Anthony Aiello , Pallab Bhattacharya , Hui Yuan , Zetian Mi , Nabil Bassim , Robert Hovden

Organ transplantation serves as the primary therapeutic strategy for end-stage organ failures. However, allograft rejection is a common complication of organ transplantation. Histological assessment is essential for the timely detection and…

Lesion segmentation, in contrast to natural scene segmentation, requires handling subtle variations in texture and color, frequent imaging artifacts (such as hairs, rulers, and bubbles), and a critical need for precise boundary localization…

计算机视觉与模式识别 · 计算机科学 2026-05-11 Vikram Singh , Kabir Malhotra , Rohan Desai , Ananya Shankaracharya , Priyadarshini Chatterjee , Krishnan Menon Iyer

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

定量方法 · 定量生物学 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

Vascular segmentation extracts blood vessels from images and serves as the basis for diagnosing various diseases, like ophthalmic diseases. Ophthalmologists often require high-resolution segmentation results for analysis, which leads to…

图像与视频处理 · 电气工程与系统科学 2022-07-29 Yan Hu , Zhongxi Qiu , Dan Zeng , Li Jiang , Chen Lin , Jiang Liu

Anomaly detection (AD) has been an active research area in various domains. Yet, the increasing data scale, complexity, and dimension turn the traditional methods into challenging. Recently, the deep generative model, such as the…

计算机视觉与模式识别 · 计算机科学 2022-03-22 Yurong Chen , Hui Zhang , Yaonan Wang , Q. M. Jonathan Wu , Yimin Yang

Spatial Transcriptomics (ST) allows a high-resolution measurement of RNA sequence abundance by systematically connecting cell morphology depicted in Hematoxylin and Eosin (H&E) stained histology images to spatially resolved gene…

计算机视觉与模式识别 · 计算机科学 2025-03-21 Sichen Zhu , Yuchen Zhu , Molei Tao , Peng Qiu

Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

图像与视频处理 · 电气工程与系统科学 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

In this paper, we develop a complete pipeline for stain normalization, segmentation, and classification of nuclei in hematoxylin and eosin (H&E) stained breast cancer histopathology images. In the first step, we use a CNN-based stain…

计算机视觉与模式识别 · 计算机科学 2018-11-12 Edwin Yuan , Junkyo Suh

Deep learning models can generate virtual immunohistochemistry (IHC) stains from hematoxylin and eosin (H&E) images, offering a scalable and low-cost alternative to laboratory IHC. However, reliable evaluation of image quality remains a…

计算机视觉与模式识别 · 计算机科学 2025-11-07 Tushar Kataria , Shikha Dubey , Mary Bronner , Jolanta Jedrzkiewicz , Ben J. Brintz , Shireen Y. Elhabian , Beatrice S. Knudsen

Segmenting histology images into diagnostically relevant regions is imperative to support timely and reliable decisions by pathologists. To this end, computer-aided techniques have been proposed to delineate relevant regions in scanned…

The Otsu thresholding algorithm represents a fundamental technique in image segmentation, yet its computational efficiency is severely limited by exhaustive search requirements across all possible threshold values. This work presents an…

计算机视觉与模式识别 · 计算机科学 2025-09-22 Sai Varun Kodathala

Hyperspectral imaging (HSI) is an advanced medical imaging modality that captures optical data across a broad spectral range, providing novel insights into the biochemical composition of tissues. HSI may enable precise differentiation…

图像与视频处理 · 电气工程与系统科学 2024-08-07 Zhonghao Wang , Junwen Wang , Charlie Budd , Oscar MacCormac , Jonathan Shapey , Tom Vercauteren

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

定量方法 · 定量生物学 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Nuclei instance segmentation in hematoxylin and eosin (H&E)-stained images plays an important role in automated histological image analysis, with various applications in downstream tasks. While several machine learning and deep learning…

计算机视觉与模式识别 · 计算机科学 2026-01-29 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

Segmentation and quantification of white matter hyperintensities (WMHs) are of great importance in studying and understanding various neurological and geriatric disorders. Although automatic methods have been proposed for WMH segmentation…

计算机视觉与模式识别 · 计算机科学 2018-03-20 Dakai Jin , Ziyue Xu , Adam P. Harrison , Daniel J. Mollura

Melanoma is one of the most aggressive forms of skin cancer, causing a large proportion of skin cancer deaths. However, melanoma diagnoses by pathologists shows low interrater reliability. As melanoma is a cancer of the melanocyte, there is…

定量方法 · 定量生物学 2024-03-15 Mikio Tada , Ursula E. Lang , Iwei Yeh , Elizabeth S. Keiser , Maria L. Wei , Michael J. Keiser

The segmentation and automatic identification of histological regions of diagnostic interest offer a valuable aid to pathologists. However, segmentation methods are hampered by the difficulty of obtaining pixel-level annotations, which are…

图像与视频处理 · 电气工程与系统科学 2023-02-02 Pushpak Pati , Guillaume Jaume , Zeineb Ayadi , Kevin Thandiackal , Behzad Bozorgtabar , Maria Gabrani , Orcun Goksel

Histology slide digitization is becoming essential for telepathology (remote consultation), knowledge sharing (education), and using the state-of-the-art artificial intelligence algorithms (augmented/automated end-to-end clinical…

图像与视频处理 · 电气工程与系统科学 2024-05-15 Talat Zehra , Joseph Marino , Wendy Wang , Grigoriy Frantsuzov , Saad Nadeem

Weakly Supervised Semantic Segmentation (WSSS) relying only on image-level supervision is a promising approach to deal with the need for Segmentation networks, especially for generating a large number of pixel-wise masks in a given dataset.…

计算机视觉与模式识别 · 计算机科学 2023-09-21 Bharath Srinivas Prabakaran , Erik Ostrowski , Muhammad Shafique