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The segmentation of digital images is one of the essential steps in image processing or a computer vision system. It helps in separating the pixels into different regions according to their intensity level. A large number of segmentation…

计算机视觉与模式识别 · 计算机科学 2019-09-12 Amit Gurung , Sangyal Lama Tamang

Variations in hematoxylin and eosin (H&E) stained images (due to clinical lab protocols, scanners, etc) directly impact the quality and accuracy of clinical diagnosis, and hence it is important to control for these variations for a reliable…

图像与视频处理 · 电气工程与系统科学 2020-06-26 Saad Nadeem , Travis Hollmann , Allen Tannenbaum

Computer-aided diagnosis (CAD) can be used as an important tool to aid and enhance pathologists' diagnostic decision-making. Deep learning techniques, such as convolutional neural networks (CNN) and fully convolutional networks (FCN), have…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Dalí F. D. dos Santos , Paulo R. de Faria , Adriano M. Loyola , Sérgio V. Cardoso , Bruno A. N. Travençolo , Marcelo Z. do Nascimento

Recently, various deep learning methods have shown significant successes in medical image analysis, especially in the detection of cancer metastases in hematoxylin and eosin (H&E) stained whole-slide images (WSIs). However, in order to…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Yinsheng He , Xingyu Li

Virtual staining streamlines traditional staining procedures by digitally generating stained images from unstained or differently stained images. While conventional staining methods involve time-consuming chemical processes, virtual…

Modern histopathology relies on the microscopic examination of thin tissue sections stained with histochemical techniques, typically using brightfield or fluorescence microscopy. However, the staining of samples can permanently alter their…

Nuclei instance segmentation is crucial in oncological diagnosis and cancer pathology research. H&E stained images are commonly used for medical diagnosis, but pre-processing is necessary before using them for image processing tasks. Two…

图像与视频处理 · 电气工程与系统科学 2024-04-22 Zarif Ahmed , Chowdhury Nur E Alam Siddiqi , Fardifa Fathmiul Alam , Tasnim Ahmed , Tareque Mohmud Chowdhury

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial…

Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…

图像与视频处理 · 电气工程与系统科学 2022-01-20 Niccoló Marini , Manfredo Atzori , Sebastian Otálora , Stephane Marchand-Maillet , Henning Müller

Virtual staining of histopathology images (e.g., H&E-IHC) is an emerging tool in digital pathology, enabling faster and cheaper workflows by synthesizing target stains from routinely acquired slides. Yet, the quality of virtual staining…

The automatic registration of differently stained whole slide images (WSIs) is crucial for improving diagnosis and prognosis by fusing complementary information emerging from different visible structures. It is also useful to quickly…

图像与视频处理 · 电气工程与系统科学 2024-05-22 Marek Wodzinski , Niccolò Marini , Manfredo Atzori , Henning Müller

Stains are essential in histopathology to visualize specific tissue characteristics, with Haematoxylin and Eosin (H&E) serving as the clinical standard. However, pathologists frequently utilize a variety of special stains for the diagnosis…

计算机视觉与模式识别 · 计算机科学 2026-02-11 Oskar Thaeter , Christian Grashei , Anette Haas , Elisa Schmoeckel , Han Li , Peter J. Schüffler

In the clinical setting of histopathology, whole-slide image (WSI) artifacts frequently arise, distorting regions of interest, and having a pernicious impact on WSI analysis. Image-to-image translation networks such as CycleGANs are in…

图像与视频处理 · 电气工程与系统科学 2022-12-19 Cameron Dahan , Stergios Christodoulidis , Maria Vakalopoulou , Joseph Boyd

Deep learning-based virtual staining was developed to introduce image contrast to label-free tissue sections, digitally matching the histological staining, which is time-consuming, labor-intensive, and destructive to tissue. Standard…

图像与视频处理 · 电气工程与系统科学 2022-10-31 Yijie Zhang , Luzhe Huang , Tairan Liu , Keyi Cheng , Kevin de Haan , Yuzhu Li , Bijie Bai , Aydogan Ozcan

Wires and powerlines are common visual distractions that often undermine the aesthetics of photographs. The manual process of precisely segmenting and removing them is extremely tedious and may take up hours, especially on high-resolution…

计算机视觉与模式识别 · 计算机科学 2023-04-04 Mang Tik Chiu , Xuaner Zhang , Zijun Wei , Yuqian Zhou , Eli Shechtman , Connelly Barnes , Zhe Lin , Florian Kainz , Sohrab Amirghodsi , Humphrey Shi

Digital pathology, augmented by artificial intelligence (AI), holds significant promise for improving the workflow of pathologists. However, challenges such as the labor-intensive annotation of whole slide images (WSIs), high computational…

图像与视频处理 · 电气工程与系统科学 2025-04-18 Walid Rehamnia , Alexandra Getmanskaya , Evgeniy Vasilyev , Vadim Turlapov

Light-sheet fluorescence microscopy (LSFM) is a cutting-edge volumetric imaging technique that allows for three-dimensional imaging of mesoscopic samples with decoupled illumination and detection paths. Although the selective excitation…

图像与视频处理 · 电气工程与系统科学 2022-06-28 Yu Liu , Kurt Weiss , Nassir Navab , Carsten Marr , Jan Huisken , Tingying Peng

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

计算机视觉与模式识别 · 计算机科学 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Histological whole slide images (WSIs) can be usually compromised by artifacts, such as tissue folding and bubbles, which will increase the examination difficulty for both pathologists and Computer-Aided Diagnosis (CAD) systems. Existing…

图像与视频处理 · 电气工程与系统科学 2023-07-27 Zhenqi He , Junjun He , Jin Ye , Yiqing Shen

Conditional generative adversarial networks (cGANs) have enabled high-fidelity computational staining and destaining of hematoxylin and eosin (H&E) in digital pathology whole-slide images (WSI). However, their ability to generalize to…

计算机视觉与模式识别 · 计算机科学 2026-05-15 Aarushi Kulkarni , Alarice Lowe , Pratik Shah