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Self-assembly processes in biological and synthetic biomolecular systems are often governed by the spatial separation of biochemical processes. While previous work has focused on optimizing self-assembly through fine-tuned reaction…

生物物理 · 物理学 2026-02-17 Severin Angerpointner , Richard Swiderski , Erwin Frey

Swarms of coupled mobile agents subject to inter-agent wireless communication delays are known to exhibit multiple dynamic patterns in space that depend on the strength of the interactions and the magnitude of the communication delays. We…

适应与自组织系统 · 物理学 2020-08-26 Victoria Edwards , Philip deZonia , M. Ani Hsieh , Jason Hindes , Ioana Triandaf , Ira B Schwartz

It is well known that, for mass-action systems, complex-balanced equilibria are asymptotically stable. For generalized mass-action systems, even if there exists a unique complex-balanced equilibrium (in every stoichiometric class and for…

动力系统 · 数学 2022-09-14 Balazs Boros , Stefan Müller , Georg Regensburger

In this paper, we propose a novel technique, referred to as the Lyapunov Function PDEs technique, to diagnose persistence of chemical reaction networks with mass-action kinetics. The technique allows that every network is attached to a…

动力系统 · 数学 2019-02-01 Xiaoyu Zhang , Zhou Fang , Chuanhou Gao

The steady-state degree of a chemical reaction network is the number of complex steady-states for generic rate constants and initial conditions. One way to bound the steady-state degree is through the mixed volume of the steady-state system…

组合数学 · 数学 2023-04-03 Jane Ivy Coons , Mark Curiel , Elizabeth Gross

Delayed processes are ubiquitous in biological systems and are often characterized by delay differential equations (DDEs) and their extension to include stochastic effects. DDEs do not explicitly incorporate intermediate states associated…

定量方法 · 定量生物学 2016-09-28 Jingchen Feng , Stuart Sevier , Bin Huang , Dongya Jia , Herbert Levine

Swarms of large numbers of agents appear in many biological and engineering fields. Dynamic bi-stability of co-existing spatio-temporal patterns has been observed in many models of large population swarms. However, many reduced models for…

斑图形成与孤子 · 物理学 2015-06-17 Luis Mier-y-Teran-Romero , Ira B. Schwartz

In matching markets such as kidney exchanges and freight exchanges, delayed matching has been shown to improve overall market efficiency. The benefits of delay are highly sensitive to participants' sojourn times and departure behavior, and…

机器学习 · 计算机科学 2026-02-27 Ruiqi Zhou , Donghao Zhu , Houcai Shen

We establish that mass conserving single terminal-linkage networks of chemical reactions admit positive steady states regardless of network deficiency and the choice of reaction rate constants. This result holds for closed systems without…

分子网络 · 定量生物学 2015-03-19 Santiago Akle , Onkar Dalal , Ronan M. T. Fleming , Michael Saunders , Nicole Taheri , Yinyu Ye

Delay mass-action systems provide a model of chemical kinetics when past states influence the current dynamics. In this work, we provide a graph-theoretic condition for delay stability, i.e., linear stability independent of both rate…

动力系统 · 数学 2021-05-18 Gheorghe Craciun , Maya Mincheva , Casian Pantea , Polly Y. Yu

We present a systematic approach to reveal the correspondence between time delay dynamics and networks of coupled oscillators. After early demonstrations of the usefulness of spatio-temporal representations of time-delay system dynamics,…

适应与自组织系统 · 物理学 2023-04-17 Joseph D. Hart , Laurent Larger , Thomas E. Murphy , Rajarshi Roy

The stationary-state spatial structure of reacting scalar fields, chaotically advected by a two-dimensional large-scale flow, is examined for the case for which the reaction equations contain delay terms. Previous theoretical investigations…

流体动力学 · 物理学 2015-05-13 Alexandra Tzella , Peter H. Haynes

Mass-action kinetics is frequently used in systems biology to model the behaviour of interacting chemical species. Many important dynamical properties are known to hold for such systems if they are weakly reversible and have a low…

动力系统 · 数学 2014-07-15 Matthew D. Johnston , David Siegel , Gábor Szederkényi

Swarm and modular robotics are an emerging area in control of autonomous systems. However, coordinating a large group of interacting autonomous agents requires careful consideration of the logistical issues involved. In particular,…

斑图形成与孤子 · 物理学 2015-07-15 K. Szwaykowska , L. Mier-y-Teran-Romero , I. B. Schwartz

A detailed understanding of biochemical networks at the molecular level is essential for studying complex cellular processes. In this paper, we provide a comprehensive description of biochemical networks by considering individual atoms and…

分子网络 · 定量生物学 2025-04-08 Hadjar Rahou , Hulda S. Haraldsdottir , Filippo Martinelli , Ines Thiele , Ronan M. T. Fleming

We investigate the emergence of sustained spatio-temporal behaviors in reaction-phase separation systems. We focus on binary systems, in which either one or both species can phase separate, and we discuss the stability of the homogeneous…

斑图形成与孤子 · 物理学 2024-08-08 Dino Osmanovic , Elisa Franco

Here we focus on the challenge of verifying the correctness of molecular implementations of abstract chemical reaction networks, where operation in a well-mixed "soup" of molecules is stochastic, asynchronous, concurrent, and often involves…

计算工程、金融与科学 · 计算机科学 2019-10-01 Seung Woo Shin , Chris Thachuk , Erik Winfree

Networks of interconnected agents are essential to study complex networked systems' state evolution, stability, resilience, and control. Nevertheless, the high dimensionality and nonlinear dynamics are vital factors preventing us from…

物理与社会 · 物理学 2023-08-24 Cheng Ma , Gyorgy Korniss , Boleslaw K. Szymanski , Jianxi Gao

Polynomial dynamical systems (DSs) can model a wide range of physical processes. A special subset of these DSs that can model chemical reactions under mass-action kinetics is called chemical dynamical systems (CDSs). A fundamental problem,…

分子网络 · 定量生物学 2025-08-04 Tomislav Plesa

In this paper, we obtain sufficient conditions for the permanence of a family of nonautonomous systems of delay differential equations. This family includes structured models from mathematical biology, with either discrete or distributed…

动力系统 · 数学 2021-06-22 Teresa Faria