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We consider the problem in precision health of grouping people into subpopulations based on their degree of vulnerability to a risk factor. These subpopulations cannot be discovered with traditional clustering techniques because their…

机器学习 · 统计学 2018-12-11 Alexander New , Kristin P. Bennett

We use the multiscale entanglement renormalisation ansatz (MERA) to numerically investigate three critical quantum spin chains with Z_2 x Z_2 on-site symmetry: a staggered XXZ model, a transverse field cluster model, and the quantum…

强关联电子 · 物理学 2015-04-28 Jacob C. Bridgeman , Aroon O'Brien , Stephen D. Bartlett , Andrew C. Doherty

We propose a new class of robust and Fisher-consistent estimators for mixture models. These estimators can be used to construct robust model-based clustering procedures. We study in detail the case of multivariate normal mixtures and…

统计方法学 · 统计学 2021-06-09 Juan D. Gonzalez , Ricardo Maronna , Victor J. Yohai , Ruben H. Zamar

Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned to the study's objectives. Cluster randomised trials require additional attributes to be defined within the estimand compared to…

统计方法学 · 统计学 2024-02-23 Brennan C Kahan , Bryan Blette , Michael Harhay , Scott Halpern , Vipul Jairath , Andrew Copas , Fan Li

Variational Auto-Encoders (VAEs) have been widely applied for learning compact, low-dimensional latent representations of high-dimensional data. When the correlation structure among data points is available, previous work proposed…

机器学习 · 计算机科学 2019-12-20 Da Tang , Dawen Liang , Nicholas Ruozzi , Tony Jebara

We propose a modification of linear discriminant analysis, referred to as compressive regularized discriminant analysis (CRDA), for analysis of high-dimensional datasets. CRDA is specially designed for feature elimination purpose and can be…

统计方法学 · 统计学 2018-04-12 Muhammad Naveed Tabassum , Esa Ollila

Covariate adjustment and methods of incorporating historical data in randomized clinical trials (RCTs) each provide opportunities to increase trial power. We unite these approaches for the analysis of RCTs with binary outcomes based on the…

统计方法学 · 统计学 2022-12-21 Alyssa M. Vanderbeek , Jessica L. Ross , David P. Miller , Alejandro Schuler

This study introduces a general semiparametric clusterwise index distribution model to analyze how latent clusters affect the covariate-response relationships. By employing sufficient dimension reduction to account for the effects of…

统计方法学 · 统计学 2025-09-30 Jen-Chieh Teng , Chin-Tsang Chiang

Markov chain Monte Carlo (MCMC) algorithms are used to estimate features of interest of a distribution. The Monte Carlo error in estimation has an asymptotic normal distribution whose multivariate nature has so far been ignored in the MCMC…

统计理论 · 数学 2016-07-05 Dootika Vats , James M. Flegal , Galin L. Jones

In randomized clinical trials, adjustments for baseline covariates at both design and analysis stages are highly encouraged by regulatory agencies. A recent trend is to use a model-assisted approach for covariate adjustment to gain…

统计方法学 · 统计学 2021-07-14 Ting Ye , Jun Shao , Yanyao Yi , Qingyuan Zhao

Prediction models are used amongst others to inform medical decisions on interventions. Typically, individuals with high risks of adverse outcomes are advised to undergo an intervention while those at low risk are advised to refrain from…

The Calculus of Wrapped Compartments (CWC) is a variant of the Calculus of Looping Sequences (CLS). While keeping the same expressiveness, CWC strongly simplifies the development of automatic tools for the analysis of biological systems.…

计算工程、金融与科学 · 计算机科学 2010-06-29 Mario Coppo , Ferruccio Damiani , Maurizio Drocco , Elena Grassi , Angelo Troina

We propose a new supervised learning algorithm, for classification and regression problems where two or more preliminary predictors are available. We introduce \texttt{KernelCobra}, a non-linear learning strategy for combining an arbitrary…

机器学习 · 计算机科学 2020-02-05 Benjamin Guedj , Bhargav Srinivasa Desikan

In biomedical studies, we are often interested in the association between different types of covariates and the times to disease events. Because the relationship between the covariates and event times is often complex, standard survival…

统计方法学 · 统计学 2024-01-19 Hoi Min Ng , Kin Yau Wong

For a high-dimensional linear model with a finite number of covariates measured with error, we study statistical inference on the parameters associated with the error-prone covariates, and propose a new corrected decorrelated score test and…

统计方法学 · 统计学 2020-01-29 Mengyan Li , Runze Li , Yanyuan Ma

In various applications with large spatial regions, the relationship between the response variable and the covariates is expected to exhibit complex spatial patterns. We propose a spatially clustered varying coefficient model, where the…

统计方法学 · 统计学 2020-07-21 Fangzheng Lin , Yanlin Tang , Huichen Zhu , Zhongyi Zhu

Cluster analysis is a fundamental tool for pattern discovery of complex heterogeneous data. Prevalent clustering methods mainly focus on vector or matrix-variate data and are not applicable to general-order tensors, which arise frequently…

统计方法学 · 统计学 2021-06-29 Eric C. Chi , Brian R. Gaines , Will Wei Sun , Hua Zhou , Jian Yang

This paper shows that sequential statistical analysis techniques can be generalised to the problem of selecting between alternative forecasting methods using scoring rules. A return to basic principles is necessary in order to show that…

统计理论 · 数学 2025-05-15 David T. Frazier , Donald S. Poskitt

Stepped wedge cluster randomized trials (SWCRTs) often face challenges with potential confounding by time trends. Traditional frequentist methods can fail to provide adequate coverage of the intervention's true effect using confidence…

统计方法学 · 统计学 2024-02-02 Danni Wu , Hyung G. Park , Corita R. Grudzen , Keith S. Goldfeld

Prognostic covariate adjustment (PROCOVA) is a two-sample two-stage estimation method used in randomized controlled trials. In the first stage, a prognostic score, defined as the conditional expectation of an outcome given covariates under…

统计方法学 · 统计学 2026-05-01 Nodoka Seya , Masataka Taguri