相关论文: Tracking the Dynamics of the Tear Film Lipid Layer

With a prevalence of 5 to 50%, Dry Eye Disease (DED) is one of the leading reasons for ophthalmologist consultations. The diagnosis and quantification of DED usually rely on ocular surface analysis through slit-lamp examinations. However,…

The human tear film (TF) is thin multilayer fluid film that is critical for clear vision and ocular surface health. Its dynamics are strongly affected by a floating lipid layer and, in health, that layer slows evaporation and helps create a…

Dry eye disease (DED) has a prevalence of between 5 and 50\%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. Many tests…

Evaporation profiles have a strong effect on tear film thinning and breakup (TBU), a key factor in dry eye disease (DED). In experiments, TBU is typically seen to occur in patterns that locally can be circular (spot), linear (streak), or…

Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical…

Dry eye disease (DED) affects approximately half of the United States population. DED is characterized by dryness on the corena surface due to a variety of causes. This study fills the spatiotemporal gaps in DED epidemiology by using Google…

Tear film (TF) breakup is a key driver of understanding dry eye disease, yet estimating TF thickness and osmolarity from fluorescence (FL) imaging typically requires solving computationally expensive inverse problems. We propose an operator…

Etiologies of tear breakup include evaporation-driven, divergent flow-driven, and a combination of these two. A mathematical model incorporating evaporation and lipid-driven tangential flow is fit to fluorescence imaging data. The…

The contribution of different physical effects to tear breakup (TBU) in subjects with no self-reported history of dry eye are quantified. An automated system using a convolutional neural network is deployed on fluorescence (FL) imaging…

The rising prevalence of vision-threatening retinal diseases poses a significant burden on the global healthcare systems. Deep learning (DL) offers a promising solution for automatic disease screening but demands substantial data.…

The tear film (TF) plays a critical role in maintaining ocular surface health, and its disruption through tear breakup (TBU) is closely associated with dry eye disease. Evaporation-driven thinning is a primary mechanism underlying TBU, yet…

One of the main roles of the lipid layer (LL) of the tear film (TF) is to help prevent evaporation of the aqueous layer (AL). The LL thickness, composition, and structure all contribute to its barrier function. It is believed that the lipid…

During the upstroke of a normal eye blink, the upper lid moves and paints a thin tear film over the exposed corneal and conjunctival surfaces. This thin tear film may be modeled by a nonlinear fourth-order PDE derived from lubrication…

Tear film rupture on the corneal surface plays a critical role in ocular health and visual comfort. Conventional theoretical approaches often idealize the cornea as a perfectly smooth surface, ignoring the surface roughness that are…

Tear film break-up (TFBU) analysis is critical for diagnosing dry eye syndrome, but automated TFBU segmentation remains challenging due to the lack of annotated datasets and integrated solutions. This paper introduces the Tear Film…

Purpose: To evaluate the efficacy of a recently proposed method for characterizing tear film dynamics using non-invasive high speed videokeratoscopy in assessing the loss of homeostasis of tear film. Methods: Thirty subjects, from a…

Skin diseases affect millions of people worldwide, across all ethnicities. Increasing diagnosis accessibility requires fair and accurate segmentation and classification of dermatology images. However, the scarcity of annotated medical…

Retinal disease diagnosis is critical in preventing vision loss and reducing socioeconomic burdens. Globally, over 2.2 billion people are affected by some form of vision impairment, resulting in annual productivity losses estimated at $411…

Thin liquid films on surfaces are part of our everyday life, they serve e.g. as coatings or lubricants. The stability of a thin layer is governed by interfacial forces, described by the effective interface potential, and has been subject of…

Different features of skin are associated with various medical conditions and provide opportunities to evaluate and monitor body health. This study created a strategy to assess choroidal thinning through the video analysis of facial skin.…