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DNA, with remarkable properties of high density, durability, and replicability, is one of the most appealing storage media. Emerging DNA storage technologies use composite DNA letters, where information is represented by probability…

信息论 · 计算机科学 2025-03-26 Wenkai Zhang , Zhiying Wang

DNA is a promising storage medium, but its stability and occurrence of Indel errors pose a significant challenge. The relative occurrence of Guanine(G) and Cytosine(C) in DNA is crucial for its longevity, and reverse complementary base…

信息论 · 计算机科学 2024-01-15 NallappaBhavithran G , Selvakumar R

The process of DNA-based data storage (DNA storage for short) can be mathematically modelled as a communication channel, termed DNA storage channel, whose inputs and outputs are sets of unordered sequences. To design error correcting codes…

信息论 · 计算机科学 2020-06-11 Wentu Song , Kui Cai , Kees A. Schouhamer Immink

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

信息论 · 计算机科学 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

信息论 · 计算机科学 2022-05-10 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

Most DNA sequencing technologies are based on the shotgun paradigm: many short reads are obtained from random unknown locations in the DNA sequence. A fundamental question, studied in arXiv:1203.6233, is what read length and coverage depth…

信息论 · 计算机科学 2022-02-09 Aditya Narayan Ravi , Alireza Vahid , Ilan Shomorony

We study permutations over the set of $\ell$-grams, that are feasible in the sense that there is a sequence whose $\ell$-gram frequency has the same ranking as the permutation. Codes, which are sets of feasible permutations, protect…

信息论 · 计算机科学 2021-01-18 Niv Beeri , Moshe Schwartz

For a prime $p$ and a positive integer $m$, let $\mathbb{F}_{p^m}$ be the finite field of characteristic $p$, and $\mathfrak{R}_l:=\mathbb{F}_{p^m}[v]/\langle v^l-v\rangle$ be a non-chain ring. In this paper, we study the…

信息论 · 计算机科学 2023-12-14 Ashutosh Singh , Priyanka Sharma , Om Prakash

In this paper, we consider the problem of designing DNA sequences (codewords) for DNA storage systems and DNA computing that are unlikely to fold back onto themselves to form undesirable secondary structures. The paper addresses both the…

离散数学 · 计算机科学 2016-11-17 Olgica Milenkovic , Navin Kashyap

We consider a new family of codes, termed asymmetric Lee distance codes, that arise in the design and implementation of DNA-based storage systems and systems with parallel string transmission protocols. The codewords are defined over a…

信息论 · 计算机科学 2016-12-16 Ryan Gabrys , Han Mao Kiah , Olgica Milenkovic

In modern age, the increasing complexity of computation and communication technology is leading us towards the necessity of new paradigm. As a result, unconventional approach like DNA coding theory is gaining considerable attention. The…

信息论 · 计算机科学 2023-08-07 Mandrita Mondal , Kumar S. Ray

DNA is an attractive candidate for data storage. Its millennial durability and nanometer scale offer exceptional data density and longevity. Its relevance to medical applications also drives advances in DNA-related biotechnology. To protect…

信息论 · 计算机科学 2025-11-25 Yu-Ting Lin , Hsin-Po Wang , Venkatesan Guruswami

Motivated by average-case trace reconstruction and coding for portable DNA-based storage systems, we initiate the study of \emph{coded trace reconstruction}, the design and analysis of high-rate efficiently encodable codes that can be…

信息论 · 计算机科学 2019-09-11 Mahdi Cheraghchi , Ryan Gabrys , Olgica Milenkovic , João Ribeiro

To increase the information capacity of DNA storage, composite DNA letters were introduced. We propose a novel channel model for composite DNA in which composite sequences are decomposed into ordered standard non-composite sequences. The…

信息论 · 计算机科学 2025-10-31 Besart Dollma , Ohad Elishco , Eitan Yaakobi

Coterm polynomials are introduced by Oztas et al. [a novel approach for constructing reversible codes and applications to DNA codes over the ring $F_2[u]/(u^{2k}-1)$, Finite Fields and Their Applications 46 (2017).pp. 217-234.], which…

信息论 · 计算机科学 2018-06-13 Lei Chen , Jin Li , Zhonghua Sun

DNA as a data storage medium has several advantages, including far greater data density compared to electronic media. We propose that schemes for data storage in the DNA of living organisms may benefit from studying the reconstruction…

信息论 · 计算机科学 2019-09-10 Yonatan Yehezkeally , Moshe Schwartz

We consider the problem of efficiently designing sets (codes) of equal-length DNA strings (words) that satisfy certain combinatorial constraints. This problem has numerous motivations including DNA computing and DNA self-assembly. Previous…

数据结构与算法 · 计算机科学 2007-05-23 Ming-Yang Kao , Manan Sanghi , Robert Schweller

In this paper, necessary and sufficient conditions for a cyclic code of arbitrary length over the non-chain rings $Z_{4}+\nu Z_{4}$ for $\nu^{2} \in \{0,1,\nu,2\nu,3\nu,2+\nu,2+3\nu,3+2\nu\}$ to be a reversible cyclic code have been…

信息论 · 计算机科学 2023-04-07 Nikita Jain , Sucheta Dutt , Ranjeet Sehmi

We study the amount of reliable information that can be stored in a DNA-based storage system composed of short DNA molecules. In this regime, Shomorony and Heckel (2022) put forward a conjecture on the scaling of the number of information…

信息论 · 计算机科学 2025-11-19 Ran Tamir , Nir Weinberger , Albert Guillén i Fàbregas

In this paper, we study error-correcting codes for the storage of data in synthetic deoxyribonucleic acid (DNA). We investigate a storage model where data is represented by an unordered set of $M$ sequences, each of length $L$. Errors…

信息论 · 计算机科学 2018-05-10 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi