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A mathematical algorithm to describe DNA or RNA sequences of $N$ nucleotides by a string of $2N$ integers numbers is presented in the framework of the so called crystal basis model of the genetic code. The description allows to define a not…

其他定量生物学 · 定量生物学 2017-03-06 A. Sciarrino

Genetic information is stored in a linear sequence of base-pairs; however, thermal fluctuations and complex DNA conformations such as folds and loops make it challenging to order genomic material for in vitro analysis. In this work, we…

We describe the first DNA-based storage architecture that enables random access to data blocks and rewriting of information stored at arbitrary locations within the blocks. The newly developed architecture overcomes drawbacks of existing…

信息论 · 计算机科学 2015-05-12 S. M. Hossein Tabatabaei Yazdi , Yongbo Yuan , Jian Ma , Huimin Zhao , Olgica Milenkovic

Synthetic DNA approaches 227.5 exabytes per gram of storage density with stability over millennial timescales. Realising this capacity requires error-correction codes that recover data from substantial synthesis and sequencing errors.…

信息论 · 计算机科学 2026-04-23 James L. Banal

The complexity of the primary structure of human DNA is explored using methods from nonequilibrium statistical mechanics, dynamical systems theory and information theory. The use of chi-square tests shows that DNA cannot be described as a…

基因组学 · 定量生物学 2015-06-17 A. Provata , C. Nicolis , G. Nicolis

Labeling of DNA molecules is a fundamental technique for DNA visualization and analysis. This process was mathematically modeled in [1], where the received sequence indicates the positions of the used labels. In this work, we develop error…

信息论 · 计算机科学 2025-11-04 Dganit Hanania , Eitan Yaakobi

Encoding information in combinations of pre-synthesised deoxyribonucleic acid (DNA) strands (referred to as motifs) is an interesting approach to DNA storage that could potentially circumvent the prohibitive costs of…

信息论 · 计算机科学 2024-12-05 Roman Sokolovskii , Parv Agarwal , Luis Alberto Croquevielle , Zijian Zhou , Thomas Heinis

Composite DNA is a recent method to increase the base alphabet size in DNA-based data storage.This paper models synthesizing and sequencing of composite DNA and introduces coding techniques to correct substitutions, losses of entire…

信息论 · 计算机科学 2025-10-29 Frederik Walter , Omer Sabary , Antonia Wachter-Zeh , Eitan Yaakobi

This paper considers a new alphabet set, which is a ring that we call $\mathbb{F}_4R$, to construct linear error-control codes. Skew cyclic codes over the ring are then investigated in details. We define a nondegenerate inner product and…

信息论 · 计算机科学 2021-03-01 Nasreddine Benbelkacem , Martianus Frederic Ezerman , Taher Abualrub , Aicha Batoul

The aim of this paper is to determine the algebraic structure of multidimensional cyclic codes over a finite chain ring $\mathfrak{R}$. An algorithm to find the generator polynomials of $n$ dimensional ($n$D) cyclic codes of length…

信息论 · 计算机科学 2023-03-15 Disha , Sucheta Dutt

We consider the problem of storing and retrieving information from synthetic DNA media. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on their collection of substrings…

信息论 · 计算机科学 2015-02-03 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

Designing short DNA words is a problem of constructing a set (i.e., code) of n DNA strings (i.e., words) with the minimum length such that the Hamming distance between each pair of words is at least k and the n words satisfy a set of…

数据结构与算法 · 计算机科学 2012-02-01 Ming-Yang Kao , Henry C. M. Leung , He Sun , Yong Zhang

This work concerns formal descriptions of DNA code properties, and builds on previous work on transducer descriptions of classic code properties and on trajectory descriptions of DNA code properties. This line of research allows us to give…

形式语言与自动机理论 · 计算机科学 2015-03-03 Lila Kari , Stavros Konstantinidis , Steffen Kopecki

In this paper we study error-correcting codes for the storage of data in synthetic deoxyribonucleic acid (DNA). We investigate a storage model where a data set is represented by an unordered set of $M$ sequences, each of length $L$. Errors…

信息论 · 计算机科学 2020-02-13 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

Motivated by applications in in-vivo DNA storage, we study codes for correcting duplications. A reverse-complement duplication of length $k$ is the insertion of the reversed and complemented copy of a substring of length $k$ adjacent to its…

信息论 · 计算机科学 2026-02-03 Yubo Sun , Gennian Ge

In [1], the authors proposed a new model of DNA storage system that integrates all three steps of retrieval and introduced the concept of DNA-correcting codes, which guarantees that the output of the storage system can be decoded to the…

信息论 · 计算机科学 2023-11-17 Huawei Wu

The most common gene regulation mechanism is when a transcription factor protein binds to a regulatory sequence to increase or decrease RNA transcription. However, transcription factors face two main challenges when searching for these…

定量方法 · 定量生物学 2023-11-21 Lucas Hedström , Ludvig Lizana

Maximum distance separable (MDS) codes and near MDS (NMDS) codes are of particular interest in coding theory due to their optimal error-correcting capabilities and wide applications in communication, cryptography, and storage systems. A…

信息论 · 计算机科学 2026-05-13 Yang Li , Zhenliang Lu , San Ling , Kwok-Yan Lam

In this paper, we propose a novel iterative encoding algorithm for DNA storage to satisfy both the GC balance and run-length constraints using a greedy algorithm. DNA strands with run-length more than three and the GC balance ratio far from…

信息论 · 计算机科学 2023-01-04 Seong-Joon Park , Yongwoo Lee , Jong-Seon No

Storing digital data in synthetic DNA faces challenges in ensuring data reliability in the presence of edit errors--deletions, insertions, and substitutions--that occur randomly during various stages of the storage process. Current…

信息论 · 计算机科学 2025-09-11 Serge Kas Hanna