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Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and…

统计方法学 · 统计学 2025-05-09 Zhiwei Zhang , Ya Wang , Dong Xi

Control scenarios have been identified where the use of randomized design may substantially improve the performance of dynamical decoupling methods [L. F. Santos and L. Viola, Phys. Rev. Lett. {\bf 97}, 150501 (2006)]. Here, by focusing on…

量子物理 · 物理学 2009-11-13 Lea F. Santos , Lorenza Viola

We consider the problem of evaluating designs for a two-arm randomized experiment with the criterion being the power of the randomization test for the one-sided null hypothesis. Our evaluation assumes a response that is linear in one…

统计方法学 · 统计学 2020-08-14 Abba M. Krieger , David Azriel , Michael Sklar , Adam Kapelner

We consider the problem of how to assign treatment in a randomized experiment, in which the correlation among the outcomes is informed by a network available pre-intervention. Working within the potential outcome causal framework, we…

统计方法学 · 统计学 2017-05-19 Guillaume W. Basse , Edoardo M. Airoldi

Power analyses are an important aspect of experimental design, because they help determine how experiments are implemented in practice. It is common to specify a desired level of power and compute the sample size necessary to obtain that…

统计方法学 · 统计学 2022-12-09 Zach Branson , Xinran Li , Peng Ding

A significant obstacle in the development of robust machine learning models is covariate shift, a form of distribution shift that occurs when the input distributions of the training and test sets differ while the conditional label…

机器学习 · 统计学 2021-11-17 Nilesh Tripuraneni , Ben Adlam , Jeffrey Pennington

We apply covariate adjustment to the Wincoxon two sample statistic and Wincoxon-Mann-Whitney test in comparing two treatments. The covariate adjustment through calibration not only improves efficiency in estimation/inference but also widens…

统计方法学 · 统计学 2026-02-19 Zhilan Lou , Jun Shao , Ting Ye , Tuo Wang , Yanyao Yi , Yu Du

When there is interference, a subject's outcome depends on the treatment of others and treatment effects may take on several different forms. This situation arises often, particularly in vaccine evaluation. In settings where interference is…

统计理论 · 数学 2020-01-10 Erin E Gabriel

Pocock and Simon's marginal procedure (Pocock and Simon, 1975) is often implemented forbalancing treatment allocation over influential covariates in clinical trials. However, the theoretical properties of Pocock and Simion's procedure have…

统计理论 · 数学 2020-04-08 Feifang Hu , Li-Xin Zhang

Background: It has long been advised to account for baseline covariates in the analysis of confirmatory randomised trials, with the main statistical justifications being that this increases power and, when a randomisation scheme balanced…

统计方法学 · 统计学 2021-12-09 Tim P. Morris , A. Sarah Walker , Elizabeth J. Williamson , Ian R. White

In covariate-adaptive or response-adaptive randomization, the treatment assignment and outcome can be correlated. Under this situation, re-randomization tests are a straightforward and attractive method to provide valid statistical…

统计方法学 · 统计学 2023-03-14 Yilong Zhang , Yujie Zhao , Yiwen Luo

In a clustered observational study, a treatment is assigned to groups and all units within the group are exposed to the treatment. We develop a new method for statistical adjustment in clustered observational studies using approximate…

统计方法学 · 统计学 2023-03-06 Luke Keele , Eli Ben-Michael , Lindsay Page

Randomization is a common technique used in clinical trials to eliminate potential bias and confounders in a patient population. Equal allocation to treatment groups is the standard due to its optimal efficiency in many cases. However, in…

应用统计 · 统计学 2020-04-09 Thevaa Chandereng , Xiaodan Wei , Rick Chappell

The cross-classified sampling design consists in drawing samples from a two-dimension population, independently in each dimension. Such design is commonly used in consumer price index surveys and has been recently applied to draw a sample…

统计理论 · 数学 2015-11-23 Hélène Juillard , Guillaume Chauvet , Anne Ruiz-Gazen

We consider the problem of estimating and inferring treatment effects in randomized experiments. In practice, stratified randomization, or more generally, covariate-adaptive randomization, is routinely used in the design stage to balance…

统计方法学 · 统计学 2022-09-27 Hanzhong Liu , Fuyi Tu , Wei Ma

Randomization tests are widely used to generate finite-sample valid $p$-values for causal inference on experimental data. However, when applied to subgroup analysis, these tests may lack power due to small subgroup sizes. Incorporating a…

统计方法学 · 统计学 2025-08-01 Yao Zhang , Zijun Gao

We consider quantile estimation in a semi-supervised setting, characterized by two available data sets: (i) a small or moderate sized labeled data set containing observations for a response and a set of possibly high dimensional covariates,…

统计方法学 · 统计学 2024-08-15 Abhishek Chakrabortty , Guorong Dai , Raymond J. Carroll

Covariate adjustment is widely recommended to improve statistical efficiency in randomized clinical trials (RCTs), yet empirical evidence comparing available strategies remains limited. This lack of real-world evaluation leaves unresolved…

应用统计 · 统计学 2026-02-03 Yulin Shao , Liangbo Lyu , Menggang Yu , Bingkai Wang

Stepped wedge designs (SWDs) are increasingly used to evaluate longitudinal cluster-level interventions but pose substantial challenges for valid inference. Because crossover times are randomized, intervention effects are intrinsically…

统计方法学 · 统计学 2026-05-12 Fan Xia , K. C. Gary Chan , Emily Voldal , Avi Kenny , Patrick J. Heagerty , James P. Hughes

Recently, there as been an increasing interest in the use of heavily restricted randomization designs which enforces balance on observed covariates in randomized controlled trials. However, when restrictions are strict, there is a risk that…

统计方法学 · 统计学 2021-10-15 Mattias Nordin , Mårten Schultzberg