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Stochastic reaction network models arise in intracellular chemical reactions, epidemiological models and other population process models, and are a class of continuous time Markov chains which have the nonnegative integer lattice as state…

数值分析 · 数学 2024-07-26 Muruhan Rathinam , Mingkai Yu

Background: Recently, a high number of daily positive COVID-19 cases have been reported in regions with relatively high vaccination rates; hence, booster vaccination has become necessary. In addition, infections caused by the different…

机器学习 · 计算机科学 2022-08-26 Essam A. Rashed , Sachiko Kodera , Akimasa Hirata

Strategic test allocation plays a major role in the control of both emerging and existing pandemics (e.g., COVID-19, HIV). Widespread testing supports effective epidemic control by (1) reducing transmission via identifying cases, and (2)…

统计方法学 · 统计学 2022-12-06 Ivana Malenica , Jeremy R. Coyle , Mark J. van der Laan , Maya L. Petersen

The Cox model, which remains as the first choice in analyzing time-to-event data even for large datasets, relies on the proportional hazards (PH) assumption. When survival data arrive sequentially in chunks, a fast and minimally storage…

统计方法学 · 统计学 2020-11-24 Yishu Xue , HaiYing Wang , Jun Yan , Elizabeth D. Schifano

With COVID-19 having emerged as the most widespread human pandemic disease in a century, the need to control its spread to avoid massive loss of life became more than necessary, and extremely fast. Several vaccines were developed and the…

COVID-19 testing has become a standard approach for estimating prevalence which then assist in public health decision making to contain and mitigate the spread of the disease. The sampling designs used are often biased in that they do not…

统计方法学 · 统计学 2022-02-24 Daniel Andrés Díaz-Pachón , J Sunil Rao

The interpretation of sampling data plays a crucial role in policy response to the spread of a disease during an epidemic, such as the COVID-19 epidemic of 2020. However, this is a non-trivial endeavor due to the complexity of real world…

种群与进化 · 定量生物学 2020-07-30 James D. Brunner , Nicholas Chia

Serology testing can identify past infection by quantifying the immune response of an infected individual providing important public health guidance. Individual immune responses are time-dependent, which is reflected in antibody…

定量方法 · 定量生物学 2022-08-04 Prajakta Bedekar , Anthony J. Kearsley , Paul N. Patrone

Thompson Sampling algorithm is a well known Bayesian algorithm for solving stochastic multi-armed bandit. At each time step the algorithm chooses each arm with probability proportional to it being the current best arm. We modify the…

机器学习 · 计算机科学 2017-10-09 Qiang Ha

The cataclysmic contagion based calamity -- Covid-19 has shown us a clear need for a comprehensive community based strategy that overcomes the sheer complexity of controlling it and the caveats of current methods. In this regard, as seen in…

物理与社会 · 物理学 2021-09-17 Surya Dheeshjith , Inavamsi Enaganti , Bud Mishra

We address the problem of online sequential decision making, i.e., balancing the trade-off between exploiting the current knowledge to maximize immediate performance and exploring the new information to gain long-term benefits using the…

机器学习 · 计算机科学 2022-09-20 Kartik Anand Pant , Amod Hegde , K. V. Srinivas

Bayesian optimization in large unstructured discrete spaces is often hindered by the computational cost of maximizing acquisition functions due to the absence of gradients. We propose a scalable alternative based on Thompson sampling that…

机器学习 · 计算机科学 2026-03-02 Nicolas Menet , Aleksandar Terzić , Michael Hersche , Andreas Krause , Abbas Rahimi

A new unequal probability sampling method is proposed. This method is sequential. The decision to select or not each unit is made based on the order in which the units appear. A variant of this method allows selecting a sample from a…

统计方法学 · 统计学 2021-11-17 Bardia Panahbehagh , Raphaël Jauslin , Yves Tillé

Thomas' partial likelihood estimator of regression parameters is widely used in the analysis of nested case-control data with Cox's model. This paper proposes a new estimator of the regression parameters, which is consistent and…

统计理论 · 数学 2007-06-13 Kani Chen

This paper utilizes the modified signed log-likelihood ratio method for the problem of inference about the common coefficient of variation in several independent normal populations. This method is applicable for both the problem of…

统计计算 · 统计学 2017-07-14 Mohmammad Reza Kazemi , Ali Akbar Jafari

The COVID-19 pandemic provides new motivation for a classic problem in epidemiology: estimating the empirical rate of transmission during an outbreak (formally, the time-varying reproduction number) from case counts. While standard methods…

统计方法学 · 统计学 2020-12-08 Bryan Wilder , Michael J. Mina , Milind Tambe

Response-adaptive randomization (RAR) methods can be used to adapt randomization probabilities based on accumulating data, aiming to increase the probability of allocating patients to effective treatments. A popular RAR method is Thompson…

统计方法学 · 统计学 2026-03-10 Samuel Pawel , Leonhard Held

Safe and effective preventive vaccines have the potential to help stem the HIV epidemic. The efficacy of such vaccines is typically measured in randomized, double-blind phase IIb/III trials and described as a reduction in newly acquired HIV…

统计方法学 · 统计学 2024-10-10 Yutong Jin , Alex Luedtke , Zoe Moodie , Holly Janes , David Benkeser

Recent outbreak of the novel coronavirus COVID-19 has affected all of our lives in one way or the other. While medical researchers are working hard to find a cure and doctors/nurses to attend the affected individuals, measures such as…

统计方法学 · 统计学 2020-07-23 Arkaprava Roy , Sayar Karmakar

The recent proliferation of computers and the internet have opened new opportunities for collecting and processing data. However, such data are often obtained without a well-planned probability survey design. Such non-probability based…

应用统计 · 统计学 2024-06-28 Vladislav Beresovsky , Julie Gershunskaya , Terrance D. Savitsky