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Rapid testing of appropriate specimens from patients suspected for a disease during an epidemic, such as the current Coronavirus outbreak, is of a great importance for the disease management and control. We propose a method to enhance…

定量方法 · 定量生物学 2020-04-27 Usama Kadri

We consider the problem of deciding on sampling strategy, in particular sampling design. We propose a risk measure, whose minimizing value guides the choice. The method makes use of a superpopulation model and takes into account uncertainty…

统计方法学 · 统计学 2020-07-06 Edgar Bueno , Dan Hedlin

Learning the minimum/maximum mean among a finite set of distributions is a fundamental sub-task in planning, game tree search and reinforcement learning. We formalize this learning task as the problem of sequentially testing how the minimum…

机器学习 · 统计学 2018-06-05 Emilie Kaufmann , Wouter Koolen , Aurelien Garivier

Contextual bandits constitute a classical framework for decision-making under uncertainty. In this setting, the goal is to learn the arms of highest reward subject to contextual information, while the unknown reward parameters of each arm…

机器学习 · 统计学 2024-02-19 Hongju Park , Mohamad Kazem Shirani Faradonbeh

Determining whether vaccine efficacy wanes is important for individual and public decision making. Yet, quantification of waning is a subtle task. The classical approaches cannot be interpreted as measures of declining efficacy unless we…

统计方法学 · 统计学 2026-05-21 Gellért Perényi , Matias Janvin , Mats J. Stensrud

We study the problem usually referred to as group testing in the context of COVID-19. Given n samples collected from patients, how should we select and test mixtures of samples to maximize information and minimize the number of tests? Group…

We propose a new approach that combines multiple non-parametric likelihood-type components to build a data-driven approximation of the true likelihood function. Our approach is built on empirical likelihood, a non-parametric approximation…

统计方法学 · 统计学 2017-12-15 Adam Jaeger , Nicole Lazar

We present a new, analytic, Poisson likelihood derived, technique to account for the statistical uncertainties inherent in simulation samples of limited size. This method has better coverage properties than other techniques, is valid for…

数据分析、统计与概率 · 物理学 2019-07-26 Carlos A. Argüelles , Austin Schneider , Tianlu Yuan

Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on the power…

种群与进化 · 定量生物学 2021-05-21 Rob Johnson , Chris Jackson , Anne Presanis , Sofia S. Villar , Daniela De Angelis

We elaborate on a deconvolution method, used to estimate the empirical distribution of unknown parameters, as suggested recently by Efron (2013). It is applied to estimating the empirical distribution of the 'sampling probabilities' of m…

统计理论 · 数学 2013-11-20 Eitan Greenshtein , Theodor Itskov

The test-negative design (TND) is a resource-efficient observational study design that can assess vaccine effectiveness and exposure-proximal immune correlates of disease. The TND enrolls symptomatic individuals seeking diagnostic testing…

统计方法学 · 统计学 2026-05-22 Leah I. B. Andrews , Lars van der Laan , Peter B. Gilbert

Observational data are often used to estimate real-world effectiveness and durability of vaccines. A sequence of trials can be emulated to draw inference from such data while minimizing selection bias, immortal time bias, and confounding.…

统计方法学 · 统计学 2025-09-03 Justin B. DeMonte , Bonnie E. Shook-Sa , Michael G. Hudgens

Pursuit-evasion is a multi-agent sequential decision problem wherein a group of agents known as pursuers coordinate their traversal of a spatial domain to locate an agent trying to evade them. Pursuit evasion problems arise in a number of…

机器学习 · 计算机科学 2018-11-13 Zhen Li , Nicholas J. Meyer , Eric B. Laber , Robert Brigantic

We consider a network where an infection cascade has taken place and a subset of infected nodes has been partially observed. Our goal is to reconstruct the underlying cascade that is likely to have generated these observations. We reduce…

社会与信息网络 · 计算机科学 2018-11-21 Han Xiao , Cigdem Aslay , Aristides Gionis

Multi-armed bandit methods have been used for dynamic experiments particularly in online services. Among the methods, thompson sampling is widely used because it is simple but shows desirable performance. Many thompson sampling methods for…

机器学习 · 计算机科学 2020-03-05 Sulgi Kim , Kyungmin Kim

This work is devoted to the study of the probability of immunity, i.e. the effect occurs whether exposed or not. We derive necessary and sufficient conditions for non-immunity and $\epsilon$-bounded immunity, i.e. the probability of…

统计方法学 · 统计学 2023-10-12 Jose M. Peña

Covid-19 has caused hundred of thousands of deaths and an economic damage amounting to trillions of dollars, creating a desire for the rapid development of vaccine. Once available, vaccine is gradually produced, evoking the question on how…

种群与进化 · 定量生物学 2020-06-30 Jens Grauer , Hartmut Löwen , Benno Liebchen

This work is concern with testing the low-dimensional parameters of interest with divergent dimensional data and variable selection for the rest under the sparse case. A consistent test via the partial penalized likelihood approach, called…

统计方法学 · 统计学 2014-11-20 Shanshan Wang , Hengjian Cui

Thompson sampling provides a solution to bandit problems in which new observations are allocated to arms with the posterior probability that an arm is optimal. While sometimes easy to implement and asymptotically optimal, Thompson sampling…

机器学习 · 计算机科学 2014-10-16 Dean Eckles , Maurits Kaptein

Thompson Sampling has generated significant interest due to its better empirical performance than upper confidence bound based algorithms. In this paper, we study Thompson Sampling based algorithm for Unsupervised Sequential Selection (USS)…

机器学习 · 计算机科学 2020-09-17 Arun Verma , Manjesh K. Hanawal , Nandyala Hemachandra