相关论文: A fast computational model for the electrophysiolo…

While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are characterized by a complex physiology…

We introduce a multiphysics and geometric multiscale computational model, suitable to describe the hemodynamics of the whole human heart, driven by a four-chamber electromechanical model. We first present a study on the calibration of the…

The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…

This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria. One of…

Cardiovascular disease affects millions of people worldwide and its social and economic cost clearly motivates scientific research. Computer simulation can lead to a better understanding of cardiac physiology, and for pathology presents…

Cardiac muscle cells can exhibit complex patterns including irregular behaviour such as chaos or (chaotic) early afterdepolarisations (EADs), which can lead to sudden cardiac death. Suitable mathematical models and their analysis help to…

We propose a novel partitioned scheme based on Eikonal equations to model the coupled propagation of the electrical signal in the His-Purkinje system and in the myocardium for cardiac electrophysiology. This scheme allows, for the first…

Mathematical models of the human heart are increasingly playing a vital role in understanding the working mechanisms of the heart, both under healthy functioning and during disease. The aim is to aid medical practitioners diagnose and treat…

We develop a minimal whole-heart model that describes cardiac electrical conduction and simulate a basic three-lead electrocardiogram (ECG). We compare our 3-lead ECG model with clinical data from a Norwegian athlete database. The results…

The numerical simulation of cardiac electrophysiology is a highly challenging problem in scientific computing. The Bidomain system is the most complete mathematical model of cardiac bioelectrical activity. It consists of an elliptic and a…

Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic responses.realize such advanced applications methodological key…

In previous work, Zhang et al. (2021) \cite{zhang2021integrative} developed an integrated smoothed particle hydrodynamics (SPH) method to simulate the principle aspects of cardiac function, including electrophysiology, passive and active…

We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the…

We present the meshfree Mixed Collocation Method (MCM) to solve the monodomain model for numerical simulation of cardiac electrophysiology. We apply MCM to simulate cardiac electrical propagation in 2D tissue sheets and 3D tissue slabs as…

The heart is a vital organ that relies on the orchestrated propagation of electrical stimuli to coordinate each heart beat. Abnormalities in the heart's electrical behaviour can be managed with a cardiac pacemaker. Recently, the closed-loop…

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory…

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…

Mathematical models of cardiac electrical activity are one of the most important tools for elucidating information about the heart diagnostic. Even though it is one of the major problems in biomedical research, an efficient mathematical…

Computer-based simulations of non-invasive cardiac electrical outputs, such as electrocardiograms and body surface potential maps, usually entail severe computational costs due to the need of capturing fine-scale processes and to the…

Cardiac diseases are one of the leading mortality factors in modern, industrialized societies, which cause high expenses in public health systems. Due to high costs, developing analytical methods to improve cardiac diagnostics is essential.…