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The COVID-19 pandemic is spreading rapidly around the world, causing countries to impose lockdowns and efforts to develop vaccines on a global scale. However, human-to-animal and animal-to-human transmission cannot be ignored, as severe…

种群与进化 · 定量生物学 2024-08-20 Zi Hian Tan , Kian Yan Yong , Jian-Jun Shu

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening. However, rigorous determination of SARS-COV-2 infectivity is essentially…

生物大分子 · 定量生物学 2020-06-01 Jiahui Chen , Rui Wang , Menglun Wang , Guo-Wei Wei

There are many sources of data giving information about the number of SARS-CoV-2 infections in the population, but all have major drawbacks, including biases and delayed reporting. For example, the number of confirmed cases largely…

应用统计 · 统计学 2022-06-08 Nicholas J. Irons , Adrian E. Raftery

During a virus's evolution,various regions of the genome are subjected to distinct levels of functional constraints.Combined with factors like codon bias and DNA repair efficiency,these constraints contribute to unique mutation patterns…

定量方法 · 定量生物学 2024-12-25 Vishwajeet Marathe , Deewan Bajracharya , Changhui Yan

The massive amount of genomic data appearing for SARS-CoV-2 since the beginning of the COVID-19 pandemic has challenged traditional methods for studying its dynamics. As a result, new methods such as Pangolin, which can scale to the…

定量方法 · 定量生物学 2022-11-16 Prakash Chourasia , Sarwan Ali , Simone Ciccolella , Gianluca Della Vedova , Murray Patterson

The SARS-CoV-2 pandemic has led to a significant emergence of highly mutated forms of viruses with a great ability to adapt to the human host. Some mutations resulted in changes in the amino acid sequences of viral proteins, including the…

The COVID-19 pandemic led to a large global effort to sequence SARS-CoV-2 genomes from patient samples to track viral evolution and inform public health response. Millions of SARS-CoV-2 genome sequences have been deposited in global public…

Forecasting the change in the distribution of viral variants is crucial for therapeutic design and disease surveillance. This task poses significant modeling challenges due to the sharp differences in virus distributions across…

机器学习 · 计算机科学 2025-04-24 Wenxian Shi , Menghua Wu , Regina Barzilay

SARS-CoV-2 has characteristics of wide contagion and quick propagation velocity. To analyse the visual information of it, we build a SARS-CoV-2 Microscopic Image Dataset (SC2-MID) with 48 electron microscopic images and also prepare their…

图像与视频处理 · 电气工程与系统科学 2021-03-09 Chen Li , Jiawei Zhang , Frank Kulwa , Shouliang Qi , Ziyu Qi

The widely used gene quantisation technique, Lateral Flow Device (LFD), is now commonly used to detect the presence of SARS-CoV-2. It is enabling the control and prevention of the spread of the virus. Depending on the viral load, LFD have…

机器学习 · 计算机科学 2022-05-27 Neeraj Vashistha

Real-time viral genome detection, taxonomic classification and phylogenetic analysis are critical for efficient tracking and control of viral pandemics such as Covid-19. However, the unprecedented and still growing amounts of viral genome…

机器学习 · 计算机科学 2022-10-28 Zuher Jahshan , Can Alkan , Leonid Yavits

At the end of 2020, policy responses to the SARS-CoV-2 outbreak have been shaken by the emergence of virus variants. The emergence of these more contagious, more severe, or even vaccine-resistant strains have challenged worldwide policy…

种群与进化 · 定量生物学 2021-03-29 Aymeric Vie

Because of the rapid spread of COVID-19 to almost every part of the globe, huge volumes of data and case studies have been made available, providing researchers with a unique opportunity to find trends and make discoveries like never…

机器学习 · 计算机科学 2021-10-20 Sarwan Ali , Yijing Zhou , Murray Patterson

Despite the progress in medical care, combined population-wide interventions (such as physical distancing, testing and contact tracing) are still crucial to manage the SARS-CoV-2 pandemic, aggravated by the emergence of new highly…

In the case of SARS-CoV-2 pandemic management, wastewater-based epidemiology aims to derive information on the infection dynamics by monitoring virus concentrations in the wastewater. However, due to the intrinsic random fluctuations of the…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current global COVID-19 pandemic, in which millions of lives have been lost. Understanding the zoonotic evolution of the coronavirus may provide…

种群与进化 · 定量生物学 2022-01-04 Changchuan Yin

During 2020 and 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has been increasing amongst the world's population at an alarming rate. Reducing the spread of SARS-CoV-2 and other diseases that are spread in…

社会与信息网络 · 计算机科学 2022-03-22 Patrick Urrutia , David Wren , Chrysafis Vogiatzis , Ruriko Yoshida

With recent advances in sequencing technology it has become affordable and practical to sequence genomes to very high depth-of-coverage, allowing researchers to discover low-frequency variants in the genome. However, due to the errors in…

基因组学 · 定量生物学 2021-05-10 Bryce Kille , Yunxi Liu , Nicolae Sapoval , Michael Nute , Lawrence Rauchwerger , Nancy Amato , Todd J. Treangen

The unprecedented outbreak of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), or COVID-19, continues to be a significant worldwide problem. As a result, a surge of new COVID-19 related research has followed suit. The growing…

机器学习 · 计算机科学 2021-07-21 Maksim E. Eren , Nick Solovyev , Chris Hamer , Renee McDonald , Boian S. Alexandrov , Charles Nicholas

The SARS-CoV-2 pandemic has so far unfolded diversely across the fifty United States of America, reflected both in different time progressions of infection "waves" and in magnitudes of local infection rates. Despite a marked diversity of…