相关论文: Improved inference for vaccine-induced immune resp…
Infectious diseases continue to pose significant public health challenges worldwide, requiring effective prevention and control strategies to mitigate their negative impact. Infectious diseases can be broadly classified into two groups:…
In early HIV infection, the virus population escapes from multiple CD8+ cell responses. The later an escape mutation emerges, the slower it outgrows its competition, i. e. the escape rate is lower. This pattern could indicate that the…
In recent years, there has been growing interest in causal machine learning estimators for quantifying subject-specific effects of a binary treatment on time-to-event outcomes. Estimation approaches have been proposed which attenuate the…
Win statistics have gained increasing popularity as primary analysis methods for clinical trials with hierarchical endpoints (HEs) as primary endpoints. However, existing sample size and power calculation approaches in trial design still…
Vaccines have proven effective in mitigating the threat of severe infections and deaths during outbreaks of infectious diseases. However, vaccine hesitancy (VH) complicates disease spread prediction and healthcare resource assessment across…
The application of quantum information methods to high energy physics has recently been gaining traction. In particular, reconstructing density matrices and measuring entanglement have been investigated for top quark decays and Higgs…
The contact structure of a population plays an important role in transmission of infection. Many ``structured models'' capture aspects of the contact structure through an underlying network or a mixing matrix. An important observation in…
Radio weak lensing, while a highly promising complementary probe to optical weak lensing, will require incredible precision in the measurement of galaxy shape parameters. In this paper, we extend the Bayesian Inference for Radio…
We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a…
We define a new parameter to quantify the antigenic distance between two H3N2 influenza strains: we use this parameter to measure antigenic distance between circulating H3N2 strains and the closest vaccine component of the influenza…
An important operation in geometry processing is finding the correspondences between pairs of shapes. The Gromov-Hausdorff distance, a measure of dissimilarity between metric spaces, has been found to be highly useful for nonrigid shape…
In immunological studies, the characterization of small, functionally distinct cell subsets from blood and tissue is crucial to decipher system level biological changes. An increasing number of studies rely on assays that provide…
In constant parameter compartmental models an early onset of herd immunity is at odds with estimates of R values from early stage growth. This paper utilizes a result from the theory of interest rate modeling, namely a bond pricing formula…
We revisit the controversial "abscopal" effect in the context of Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR). By allowing long interval between fractions, PULSAR may enhance systemic immune activation and…
Staggered treatment adoption arises in the evaluation of policy impact and implementation in many settings, including both randomized stepped-wedge trials and non-randomized quasi-experiments with panel data. In both settings, getting an…
Hybrid controlled trials (HCTs), which augment randomized controlled trials (RCTs) with external controls (ECs), are increasingly receiving attention as a way to address limited power, slow accrual, and ethical concerns in clinical…
We propose a unified information-geometric framework that formalizes understanding in learning as a trade-off between informativeness and geometric simplicity. An encoder phi is evaluated by U(phi) = I(phi(X); Y) - beta * C(phi), where…
Hematoxylin and eosin (H&E)-stained slides are central to cancer diagnosis and monitoring, visualizing tissue architecture and cellular morphology. However, H&E lacks the molecular specificity needed to distinguish cell states and…
The waning of immunity after recovery or vaccination is a major factor accounting for the severity and prolonged duration of an array of epidemics, ranging from COVID-19 to diphtheria and pertussis. To study the effectiveness of different…
Motivation: In predicting HIV therapy outcomes, a critical clinical question is whether using historical information can enhance predictive capabilities compared with current or latest available data analysis. This study analyses whether…