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CoV2019 has evolved to be much more dangerous than CoV2003. Experiments suggest that structural rearrangements dramatically enhance CoV2019 activity. We identify a new first stage of infection which precedes structural rearrangements by…

其他定量生物学 · 定量生物学 2021-07-14 J. C. Phillips

Whenever countries are threatened by a pandemic, as is the case with the COVID-19 virus, governments should take the right actions to safeguard public health as well as to mitigate the negative effects on the economy. In this regard, there…

机器学习 · 计算机科学 2020-05-18 Luis Miralles-Pechuán , Fernando Jiménez , Hiram Ponce , Lourdes Martínez-Villaseñor

The emergence due to the outbreak of the COVID-19 disease, caused by the SARS-CoV-2 virus, suddenly erupted at the beginning of 2020 in China and soon spread worldwide. This has caused an outstanding increase on research about the virus…

物理与社会 · 物理学 2022-03-30 Daniele Vilone , Giulia Andrighetto

Cooperation and competition between pathogens can alter the amount of individuals affected by a co-infection. Nonetheless, the evolution of the pathogens' behavior has been overlooked. Here, we consider a co-evolutionary model where the…

种群与进化 · 定量生物学 2022-03-23 Fakhteh Ghanbarnejad , Kai Seegers , Alessio Cardillo , Philipp Hövel

Evolving one-dimensional cellular automata (CAs) with genetic algorithms has provided insight into how improved performance on a task requiring global coordination emerges when only local interactions are possible. Two approaches that can…

adap-org · 物理学 2007-05-23 Justin Werfel , Melanie Mitchell , James P. Crutchfield

The COVID-19 pandemic left its unique mark on the 21st century as one of the most significant disasters in history, triggering governments all over the world to respond with a wide range of interventions. However, these restrictions come…

计算工程、金融与科学 · 计算机科学 2021-06-02 Assem Zhunis , Tung-Duong Mai , Sundong Kim

In winter of 2020, SARS-CoV-2 emerged as a global threat, impacting not only health but also financial and political stability. To address the societal need for monitoring the spread of SARS-CoV-2, many existing diagnostic technologies were…

Genetic variations in the COVID-19 virus are one of the main causes of the COVID-19 pandemic outbreak in 2020 and 2021. In this article, we aim to introduce a new type of model, a system coupled with ordinary differential equations (ODEs),…

偏微分方程分析 · 数学 2022-03-29 Xiaoqian Gong , Benedetto Piccoli

Compartmental epidemiological models categorize individuals based on their disease status, such as the SEIRD model (Susceptible-Exposed-Infected-Recovered-Dead). These models determine the parameters that influence the magnitude of an…

Although previous infection and vaccination provide protection against SARS-CoV-2 infection, both reinfection and breakthrough infection are possible events whose occurrence would increase with time after first exposure to the antigen and…

种群与进化 · 定量生物学 2022-06-07 Ariel Félix Gualtieri , Carolina de la Cal , Augusto Francisco Toma , Pedro Hecht

The mechanism of SARS-CoV-2 evolution and transmission is elusive and its understanding, a prerequisite to forecast emerging variants, is of paramount importance. SARS-CoV-2 evolution is driven by the mechanisms at molecular and organism…

种群与进化 · 定量生物学 2021-09-20 Jiahui Chen , Rui Wang , Guo-Wei Wei

Computational multi-scale pandemic modelling remains a major and timely challenge. Here we identify specific requirements for a new class of models simulating pandemics across three scales: (1) pathogen evolution, often punctuated by the…

The transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of paramount importance to the controlling and combating of coronavirus disease 2019 (COVID-19) pandemic. Currently, near 15,000 SARS-CoV-2…

基因组学 · 定量生物学 2020-08-21 Rui Wang , Yuta Hozumi , Yong-Hui Zheng , Changchuan Yin , Guo-Wei Wei

Genomic surveillance of infectious diseases allows monitoring circulating and emerging variants and quantifying their epidemic potential. However, due to the high costs associated with genomic sequencing, only a limited number of samples…

SARS-CoV-2, like any other virus, continues to mutate as it spreads, according to an evolutionary process. Unlike any other virus, the number of currently available sequences of SARS-CoV-2 in public databases such as GISAID is already…

种群与进化 · 定量生物学 2021-10-13 Sarwan Ali , Tamkanat-E-Ali , Muhammad Asad Khan , Imdadullah Khan , Murray Patterson

The outbreak and propagation of COVID-19 have posed a considerable challenge to modern society. In particular, the different restrictive actions taken by governments to prevent the spread of the virus have changed the way humans interact…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical presentation that ranges from asymptomatic, to severe disease with cytokine storm. The mortality rates also differ across the globe, ranging from 0.5-13%.…

As the year 2020 draws to an end, several new strains have been reported for the SARS-CoV-2 coronavirus, the agent responsible for the COVID-19 pandemic that has afflicted us all this past year. However, it is difficult to comprehend the…

基因组学 · 定量生物学 2023-06-09 Rene L. Warren , Inanc Birol

During pandemic events, strategies such as social distancing can be fundamental to curb viral spreading. Such actions can reduce the number of simultaneous infections and mitigate the disease spreading, which is relevant to the risk of a…

物理与社会 · 物理学 2021-02-24 Marco A. Amaral , Marcelo M. de Oliveira , Marco A. Javarone

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2, emerged into a world being rapidly transformed by artificial intelligence (AI) based on big data, computational power and neural networks. The gaze of…

计算机与社会 · 计算机科学 2020-05-26 Yipeng Hu , Joseph Jacob , Geoffrey JM Parker , David J Hawkes , John R Hurst , Danail Stoyanov