相关论文: NoisET: Noise learning and Expansion detection of …

High-throughput sequencing of B- and T-cell receptors makes it possible to track immune repertoires across time, in different tissues, and in acute and chronic diseases or in healthy individuals. However, quantitative comparison between…

Immune repertoire classification, a typical multiple instance learning (MIL) problem, is a frontier research topic in computational biology that makes transformative contributions to new vaccines and immune therapies. However, the…

Repertoire-level analysis of T cell receptors offers a biologically grounded signal for disease detection and immune monitoring, yet practical deployment is impeded by label sparsity, cohort heterogeneity, and the computational burden of…

Fundamental to quantitative characterization of the B cell receptor repertoire is clonal diversity - the number of distinct somatically recombined receptors present in the repertoire and their relative abundances, defining the search space…

High throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of these methods require a correct characterization, analysis and interpretation of…

Diverse T and B cell repertoires play an important role in mounting effective immune responses against a wide range of pathogens and malignant cells. The number of unique T and B cell clones is characterized by T and B cell receptors (TCRs…

The evolution of the adaptive immune system is characterized by changes in the relative abundances of the B- and T-cell clones that make up its repertoires. To fully capture this evolution, we need to describe the complex dynamics of the…

Falsely annotated samples, also known as noisy labels, can significantly harm the performance of deep learning models. Two main approaches for learning with noisy labels are global noise estimation and data filtering. Global noise…

Immune repertoires rely on diversity of T-cell and B-cell receptors to protect us against foreign threats. The ability to recognize a wide variety of pathogens is linked to the number of different clonotypes expressed by an individual. Out…

Deep neural networks have incredible capacity and expressibility, and can seemingly memorize any training set. This introduces a problem when training in the presence of noisy labels, as the noisy examples cannot be distinguished from clean…

Label noise is ubiquitous in various machine learning scenarios such as self-labeling with model predictions and erroneous data annotation. Many existing approaches are based on heuristics such as sample losses, which might not be flexible…

Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires (RepSeq) produces huge datasets of T-cell receptor sequences…

Identifying groups of similar objects using clustering approaches is one of the most frequently employed first steps in exploratory biomedical data analysis. Many clustering methods have been developed that pursue different strategies to…

Quantitative analysis of the dynamics of tiny cellular and sub-cellular structures, known as particles, in time-lapse cell microscopy sequences requires the development of a reliable multi-target tracking method capable of tracking numerous…

Despite recent advances, standard sequence labeling systems often fail when processing noisy user-generated text or consuming the output of an Optical Character Recognition (OCR) process. In this paper, we improve the noise-aware training…

In the field of medical image analysis, deep learning models have demonstrated remarkable success in enhancing diagnostic accuracy and efficiency. However, the reliability of these models is heavily dependent on the quality of training…

Deep neural networks (DNNs) fail to learn effectively under label noise and have been shown to memorize random labels which affect their generalization performance. We consider learning in isolation, using one-hot encoded labels as the sole…

A judicious combination of dictionary learning methods, block sparsity and source recovery algorithm are used in a hierarchical manner to identify the noises and the speakers from a noisy conversation between two people. Conversations are…

Gait recognition aims to identify individuals by recognizing their walking patterns. However, an observation is made that most of the previous gait recognition methods degenerate significantly due to two memorization effects, namely…

Learning from noisy data has attracted much attention, where most methods focus on closed-set label noise. However, a more common scenario in the real world is the presence of both open-set and closed-set noise. Existing methods typically…