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With the continued increase in the use of Bayesian methods in drug development, there is a need for statisticians to have tools to develop robust and defensible informative prior distributions. Whilst relevant empirical data should, where…

应用统计 · 统计学 2017-09-01 Nigel Dallow , Nicky Best , Timothy Montague

Prediction in a small-sized sample with a large number of covariates, the "small n, large p" problem, is challenging. This setting is encountered in multiple applications, such as precision medicine, where obtaining additional samples can…

人工智能 · 计算机科学 2017-07-14 Pedram Daee , Tomi Peltola , Marta Soare , Samuel Kaski

We consider a decision maker who must choose an action in order to maximize a reward function that depends also on an unknown parameter {\Theta}. The decision maker can delay taking the action in order to experiment and gather additional…

机器学习 · 统计学 2021-06-22 Victor F. Araman , Rene Caldentey

Subjective Bayesian prior distributions elicited from experts can be aggregated together to form group priors. This paper compares aggregated priors formed by Equal Weight Aggregation, the Classical Method, and the Sheffield Elicitation…

统计方法学 · 统计学 2021-06-29 Cameron J. Williams , Kevin J. Wilson , Nina Wilson

This article introduces a new method for eliciting prior distributions from experts. The method models an expert decision-making process to infer a prior probability distribution for a rare event $A$. More specifically, assuming there…

统计方法学 · 统计学 2023-07-17 Julia R. Falconer , Eibe Frank , Devon L. L. Polaschek , Chaitanya Joshi

Incorporation of expert information in inference or decision settings is often important, especially in cases where data are unavailable, costly or unreliable. One approach is to elicit prior quantiles from an expert and then to fit these…

统计理论 · 数学 2016-11-04 Nicholas M. Kiefer

The assurance method is growing in popularity in clinical trial planning. The method involves eliciting a prior distribution for the treatment effect, and then calculating the probability that a proposed trial will produce a `successful'…

统计方法学 · 统计学 2019-05-30 Ziyad A. Alhussain , Jeremy E. Oakley

Background: The uptake of formalized prior elicitation from experts in Bayesian clinical trials has been limited due to challenges such as complex statistical modeling, lack of practical tools, and the cognitive burden placed on experts…

统计方法学 · 统计学 2025-09-15 Yongdong Ouyang , Janice J Eng , Denghuang Zhan , Hubert Wong , The WnW Research Team

It is important to collect credible training samples $(x,y)$ for building data-intensive learning systems (e.g., a deep learning system). Asking people to report complex distribution $p(x)$, though theoretically viable, is challenging in…

机器学习 · 计算机科学 2021-02-26 Jiaheng Wei , Zuyue Fu , Yang Liu , Xingyu Li , Zhuoran Yang , Zhaoran Wang

Recent work [ 14 ] has introduced a method for prior elicitation that utilizes records of expert decisions to infer a prior distribution. While this method provides a promising approach to eliciting expert uncertainty, it has only been…

机器学习 · 计算机科学 2025-01-22 Julia R. Falconer , Eibe Frank , Devon L. L. Polaschek , Chaitanya Joshi

Expert elicitation is an invaluable tool for gaining insights into the degree of clinical knowledge surrounding parameters of interest when designing, or supplementing trial data when analysing, a clinical trial. Elicitation is considered…

应用统计 · 统计学 2025-08-11 Laura M. Morgan , James M. S. Wason , Kevin J. Wilson , Nina Wilson

We consider the problem of eliciting expert assessments of an uncertain parameter. The context is risk control, where there are, in fact, three uncertain parameters to be estimates. Two of these are probabilities, requiring the that the…

人工智能 · 计算机科学 2020-10-23 Paul B. Kantor

Diversification is a useful tool for exploring large collections of information items. It has been used to reduce redundancy and cover multiple perspectives in information-search settings. Diversification finds applications in many…

数据结构与算法 · 计算机科学 2026-02-05 Honglian Wang , Sijing Tu , Aristides Gionis

Substudies of the Childhood Asthma Management Program [Control. Clin. Trials 20 (1999) 91-120; N. Engl. J. Med. 343 (2000) 1054-1063] seek to identify patient characteristics associated with asthma symptoms and lung function. To determine…

Nowadays, recommender systems (RSes) are becoming increasingly important to individual users and business marketing, especially in the online e-commerce scenarios. However, while the majority of recommendation algorithms proposed in the…

社会与信息网络 · 计算机科学 2020-04-27 Ya-Hui An , Qiang Dong , Quan Yuan , Chao Wang

Prior distributions must be specified for the parameters of interest in a Bayesian clinical trial. When existing evidence on the effects of the trial interventions is limited, prior distributions can be constructed with expert elicitation.…

We investigate the application of classification techniques to utility elicitation. In a decision problem, two sets of parameters must generally be elicited: the probabilities and the utilities. While the prior and conditional probabilities…

人工智能 · 计算机科学 2013-02-01 Urszula Chajewska , Lise Getoor , Joseph Norman , Yuval Shahar

The prior distribution for the unknown model parameters plays a crucial role in the process of statistical inference based on Bayesian methods. However, specifying suitable priors is often difficult even when detailed prior knowledge is…

统计方法学 · 统计学 2020-03-18 Marcelo Hartmann , Georgi Agiashvili , Paul Bürkner , Arto Klami

Expert opinion plays an important role when selecting promising clusters of chemical compounds in the drug discovery process. We propose a method to quantify these qualitative assessments using hierarchical models. However, with the most…

应用统计 · 统计学 2015-02-04 Elasma Milanzi , Ariel Alonso , Christophe Buyck , Geert Molenberghs , Luc Bijnens

Large language models (LLMs) are increasingly deployed in high-stakes settings where good decisions require forming beliefs over the probability of unknown outcomes. However, it is unclear whether LLMs act as if they hold coherent beliefs…

人工智能 · 计算机科学 2026-05-12 Khurram Yamin , Jingjing Tang , Santiago Cortes-Gomez , Amit Sharma , Eric Horvitz , Bryan Wilder
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