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We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

光学 · 物理学 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller

Conventional stereo suffers from a fundamental trade-off between imaging volume and signal-to-noise ratio (SNR) -- due to the conflicting impact of aperture size on both these variables. Inspired by the extended depth of field cameras, we…

计算机视觉与模式识别 · 计算机科学 2021-04-13 Shiyu Tan , Yicheng Wu , Shoou-I Yu , Ashok Veeraraghavan

Photoacoustic computed tomography (PACT), also known as optoacoustic tomography, is an emerging imaging technique that holds great promise for biomedical imaging. PACT is a hybrid imaging method that can exploit the strong endogenous…

医学物理 · 物理学 2019-05-13 Joemini Poudel , Yang Lou , Mark A. Anastasio

Optical coherence tomography (OCT) microscope (OCM) uses a high-numerical-aperture objective to achieve cellular-level lateral resolution. However, its practical imaging depth range is limited by the depth of focus (DOF). Although…

Optical microscopy has so far been restricted to superficial layers, leaving many important biological questions unanswered. Random scattering causes the ballistic focus, which is conventionally used for image formation, to decay…

光学 · 物理学 2012-08-28 Ke Si , Reto Fiolka , Meng Cui

Photoacoustic (PA) imaging has the potential to revolutionize functional medical imaging in healthcare due to the valuable information on tissue physiology contained in multispectral photoacoustic measurements. Clinical translation of the…

We report a novel microscopy platform, termed Multi-Aperture Fourier ptychographic microscopy (MA-FPM), capable of realizing gigapixel complex field images with large data acquisition bandwidths - in gigapixels per second. MA-FPM is a…

光学 · 物理学 2020-10-14 Pavan Chandra Konda , Jonathan M. Taylor , Andrew R. Harvey

In deep tissue photoacoustic imaging the spatial resolution is inherently limited by the acoustic wavelength. Recently, it was demonstrated that it is possible to surpass the acoustic diffraction limit by analyzing fluctuations in a set of…

Light scattering by tissue severely limits how deep beneath the surface one can image, and the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is one of the most powerful techniques for imaging deep…

图像与视频处理 · 电气工程与系统科学 2021-05-31 Yongyi Zhao , Ankit Raghuram , Hyun K. Kim , Andreas H. Hielscher , Jacob T. Robinson , Ashok Veeraraghavan

Linear-array based photoacoustic images are reconstructed using the conventional delay-and-sum (DAS) beamforming method. Although the DAS beamformer is well suited for PA image formation, reconstructed images are often afflicted by noises,…

医学物理 · 物理学 2022-10-05 Sufayan Mulani , Souradip Paul , Mayanglambam Suheshkumar Singh

Photonic quantum technologies utilize various degrees of freedom (DOFs) of light, such as polarization, frequency, and spatial modes, to encode quantum information. In the effort of further improving channel capacity of quantum…

量子物理 · 物理学 2026-04-30 Roey Shafran , Ron Ziv , Mordechai Segev

Data limitation is a significant challenge in applying deep learning to medical images. Recently, the diffusion probabilistic model (DPM) has shown the potential to generate high-quality images by converting Gaussian random noise into…

计算机视觉与模式识别 · 计算机科学 2024-08-26 Sepehr Salem Ghahfarokhi , Tyrell To , Julie Jorns , Tina Yen , Bing Yu , Dong Hye Ye

As a hybrid imaging technology, photoacoustic microscopy (PAM) imaging suffers from noise due to the maximum permissible exposure of laser intensity, attenuation of ultrasound in the tissue, and the inherent noise of the transducer.…

图像与视频处理 · 电气工程与系统科学 2022-01-13 Da He , Jiasheng Zhou , Xiaoyu Shang , Jiajia Luo , Sung-Liang Chen

One of the common algorithms used to reconstruct photoacoustic (PA) images is the non-adaptive Delay-and-Sum (DAS) beamformer. However, the quality of the reconstructed PA images obtained by DAS is not satisfying due to its high level of…

信号处理 · 电气工程与系统科学 2018-02-13 Roya Paridar , Moein Mozaffarzadeh , Mohammadreza Nasiriavanaki , Mahdi Orooji

Fourier Ptychographic Microscopy (FPM) is a computational imaging method that is able to super-resolve features beyond the diffraction-limit set by the objective lens of a traditional microscope. This is accomplished by using synthetic…

信号处理 · 电气工程与系统科学 2019-04-09 Michael Kellman , Emrah Bostan , Michael Chen , Laura Waller

Accurate measurement of optical absorption coefficients from photoacoustic imaging (PAI) data would enable direct mapping of molecular concentrations, providing vital clinical insight. The ill-posed nature of the problem of absorption…

图像与视频处理 · 电气工程与系统科学 2023-06-13 Janek Gröhl , Thomas R. Else , Lina Hacker , Ellie V. Bunce , Paul W. Sweeney , Sarah E. Bohndiek

We present a compressive beamforming method for coherent plane-wave compounding (CPWC) ultrasound imaging based on a far-field decomposition of the received radiofrequency (RF) data into virtual plane waves. This decomposition recasts the…

信号处理 · 电气工程与系统科学 2026-03-25 Nikunj Khetan , Jerome Mertz

We present a method for the recovery of compressively sensed acoustic fields using patterned, instead of point-by-point, detection. From a limited number of such compressed measurements, we propose to reconstruct the field on the sensor…

In Photoacoustic imaging (PAI), the most prevalent beamforming algorithm is delay-and-sum (DAS) due to its simple implementation. However, it results in a low quality image affected by the high level of sidelobes. Coherence factor (CF) can…

信号处理 · 电气工程与系统科学 2017-10-10 Moein Mozaffarzadeh , Mohammad Mehrmohammadi , Bahador Makkiabadi

Optoacoustic (OA) imaging is based on excitation of biological tissues with nanosecond-duration laser pulses followed by subsequent detection of ultrasound waves generated via light-absorption-mediated thermoelastic expansion. OA imaging…

图像与视频处理 · 电气工程与系统科学 2023-05-04 Firat Ozdemir , Berkan Lafci , Xosé Luís Deán-Ben , Daniel Razansky , Fernando Perez-Cruz