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Electronic health records (EHRs) linked with familial relationship data offer a unique opportunity to investigate the genetic architecture of complex phenotypes at scale. However, existing heritability and coheritability estimation methods…

统计方法学 · 统计学 2025-11-12 Yinjun Zhao , Nicholas Tatonetti , Yuanjia Wang

Electronic health record (EHR) data has emerged as a valuable resource for analyzing patient health status. However, the prevalence of missing data in EHR poses significant challenges to existing methods, leading to spurious correlations…

机器学习 · 计算机科学 2024-05-16 Zhihao Yu , Xu Chu , Yujie Jin , Yasha Wang , Junfeng Zhao

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

定量方法 · 定量生物学 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

The scarcity of labeled action data poses a considerable challenge for developing machine learning algorithms for robotic object manipulation. It is expensive and often infeasible for a robot to interact with many objects. Conversely,…

机器人学 · 计算机科学 2024-12-03 Emily Liu , Michael Noseworthy , Nicholas Roy

Typically, electronic health record data are not collected towards a specific research question. Instead, they comprise numerous observations recruited at different ages, whose medical, environmental and oftentimes also genetic data are…

统计方法学 · 统计学 2024-11-19 Nir Keret , Malka Gorfine

Current cancer screening guidelines cover only a few cancer types and rely on narrowly defined criteria such as age or a single risk factor like smoking history, to identify high-risk individuals. Predictive models using electronic health…

In modern machine learning applications, frequent encounters of covariate shift and label scarcity have posed challenges to robust model training and evaluation. Numerous transfer learning methods have been developed to robustly adapt the…

统计方法学 · 统计学 2022-11-22 Linshanshan Wang , Xuan Wang , Katherine P. Liao , Tianxi Cai

Electronic Health Records (EHRs) contain rich patient information and are crucial for clinical research and practice. In recent years, deep learning models have been applied to EHRs, but they often rely on massive features, which may not be…

机器学习 · 计算机科学 2024-06-11 Ran Xu , Yiwen Lu , Chang Liu , Yong Chen , Yan Sun , Xiao Hu , Joyce C Ho , Carl Yang

We introduce HTAD, a novel model for diagnosis prediction using Electronic Health Records (EHR) represented as Heterogeneous Information Networks. Recent studies on modeling EHR have shown success in automatically learning representations…

机器学习 · 计算机科学 2019-12-24 Anahita Hosseini , Tyler Davis , Majid Sarrafzadeh

Semi-supervised multi-label feature selection has recently been developed to solve the curse of dimensionality problem in high-dimensional multi-label data with certain samples missing labels. Although many efforts have been made, most…

机器学习 · 计算机科学 2025-10-10 Li Yang , Yanyong Huang , Dongjie Wang , Ke Li , Xiuwen Yi , Fengmao Lv , Tianrui Li

In biomedical studies, it is often desirable to characterize the interactive mode of multiple disease outcomes beyond their marginal risk. Ising model is one of the most popular choices serving for this purpose. Nevertheless, learning…

统计方法学 · 统计学 2023-11-28 Daiqing Wu , Molei Liu

This paper introduces an innovative Electronic Health Record (EHR) foundation model that integrates Polygenic Risk Scores (PRS) as a foundational data modality, moving beyond traditional EHR-only approaches to build more holistic health…

Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

计算机视觉与模式识别 · 计算机科学 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

We present the development of a semi-supervised regression method using variational autoencoders (VAE), which is customized for use in soft sensing applications. We motivate the use of semi-supervised learning considering the fact that…

机器学习 · 计算机科学 2022-12-12 Yilin Zhuang , Zhuobin Zhou , Burak Alakent , Mehmet Mercangöz

The use of Electronic Health Records (EHRs) has increased dramatically in the past 15 years, as, it is considered an important source of managing data od patients. The EHRs are primary sources of disease diagnosis and demographic data of…

机器学习 · 计算机科学 2024-04-02 Bushra F. Alsaqer , Alaa F. Alsaqer , Amna Asif

Physiological measurements involves observing variables that attribute to the normative functioning of human systems and subsystems directly or indirectly. The measurements can be used to detect affective states of a person with aims such…

机器学习 · 计算机科学 2022-10-31 Nibraas Khan , Nilanjan Sarkar

A notable challenge of leveraging Electronic Health Records (EHR) for treatment effect assessment is the lack of precise information on important clinical variables, including the treatment received and the response. Both treatment…

统计方法学 · 统计学 2021-10-26 Jue Hou , Rajarshi Mukherjee , Tianxi Cai

Rare diseases affect an estimated 300-400 million people worldwide, yet individual conditions remain underdiagnosed and poorly characterized due to their low prevalence and limited clinician familiarity. Computational phenotyping offers a…

Motivation: Electronic health record (EHR) data provides a new venue to elucidate disease comorbidities and latent phenotypes for precision medicine. To fully exploit its potential, a realistic data generative process of the EHR data needs…

Annotating histopathological images is a time-consuming andlabor-intensive process, which requires broad-certificated pathologistscarefully examining large-scale whole-slide images from cells to tissues.Recent frontiers of transfer learning…

计算机视觉与模式识别 · 计算机科学 2020-08-24 Dou Xu , Chang Cai , Chaowei Fang , Bin Kong , Jihua Zhu , Zhongyu Li