相关论文: An Immuno-Epidemiological Vector-Host Model with W…

We present an epidemiological model for vector-borne diseases that includes within-host viral load and antibody dynamics using structured transport equations. By incorporating the internal dynamics into the infected and recovered host…

Cholera, a severe gastrointestinal infection caused by the bacterium Vibrio cholerae, remains a major threat to public health with a yearly estimated global burden of 2.9 million cases. Although the majority of existing models for the…

Mathematical models of infectious disease transmission typically neglect within-host dynamics. Yet within-host dynamics - including pathogen replication, host immune responses, and interactions with microbiota - are crucial not only for…

Chronic viral infections can persist in an infected person for decades. From the perspective of the virus, a single infection can span thousands of generations, leading to a highly diverse population of viruses with its own complex…

We present a methodology providing a one-directional link from within-host individual heterogeneity to population-level disease transmission dynamics. The methodology works in several steps. A within-host model is investigated numerically…

We formulate a multi-group and multi-vector epidemic model in which hosts' dynamics is captured by staged-progression $SEIR$ framework and the dynamics of vectors is captured by an $SI$ framework. The proposed model describes the evolution…

We propose an epidemic model for the spread of vector-borne diseases. The model, which is built extending the classical susceptible-infected-susceptible model, accounts for two populations -- humans and vectors -- and for cross-contagion…

Infectious disease dynamics operate across multiple biological scales, with within-host viral dynamics being a key driver of between-host transmission. However, while models that explicitly link these scales exist, none have been developed…

In this study, we develop and analyze a nested multi-scale model for COVID -19 disease that integrates within-host scale and between-host scale sub-models. First, the well-posedness of the multi-scale model is discussed, followed by the…

In this paper we study a diffusive age structured epidemic model with disease transmission between vector and host populations. The dynamics of the populations are described by reaction-diffusion equations, with infection age structure of…

Vector-borne diseases often infect multiple host species, increasing the likelihood of disease persistence due to the presence of multiple reservoirs. Vector biting patterns and feeding preferences can shift in response to selective…

The dynamics of epidemic spreading is often reduced to the single control parameter $R_0$, whose value, above or below unity, determines the state of the contagion. If, however, the pathogen evolves as it spreads, $R_0$ may change over…

Infectious disease spread is a multi-scale process composed of within-host (biological) and between-host (social) drivers and disentangling them from each other is a central challenge in epidemiology. Here, we introduce VIBES, a multi-scale…

Viral infections trigger complex immune responses with heterogeneous outcomes shaped by nonlinear feedbacks. An ordinary differential equation model is developed to investigate immune response dynamics during viral infection, incorporating…

A multi-patch and multi-group modeling framework describing the dynamics of a class of diseases driven by the interactions between vectors and hosts structured by groups is formulated. Hosts' dispersal is modeled in terms of patch-residence…

We propose and analyze an epidemiological model for vector borne diseases that integrates a multi-stage vector population and several host sub-populations which may be characterized by a variety of compartmental model types: subpopulations…

The resurgence of vector-borne diseases is an increasing public health concern, and there is a need for a better understanding of their dynamics. For a number of diseases, e.g. dengue and chikungunya, this resurgence occurs mostly in urban…

Despite being similar in structure, functioning, and size viral pathogens enjoy very different mostly well-defined ways of life. They occupy their hosts for a few days (influenza), for a few weeks (measles), or even lifelong (HCV), which…

Stochastic epidemic models, generally more realistic than deterministic counterparts, have often been seen too complex for rigorous mathematical analysis because of level of details it requires to comprehensively capture the dynamics of…

Many vector-borne disease epidemic models neglect the fact that in modern human civilization, social awareness as well as self-defence system are overwhelming against advanced propagation of the disease. News are becoming more effortlessly…