相关论文: Voice Biomarker Identification for Effects of Deep…

Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system characterized by motor and non-motor symptoms. As the disease progresses, patients alternate periods in which motor symptoms are mitigated due to…

Deep brain stimulation (DBS) is an advanced surgical treatment for the symptoms of Parkinson's disease (PD), involving electrical stimulation of neurons within the basal ganglia region of the brain. DBS is traditionally delivered in an…

Parkinson's disease (PD) is a progressive neurodegenerative disorder that, in addition to directly impairing functional mobility, is frequently associated with vocal impairments such as hypophonia and dysarthria, which typically manifest in…

Deep Brain Stimulation (DBS) is a highly effective treatment for Parkinson's Disease (PD). Recent research uses reinforcement learning (RL) for DBS, with RL agents modulating the stimulation frequency and amplitude. But, these models rely…

Decoding motor performance from brain signals offers promising avenues for adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD). In a two-center cohort of 19 PD patients executing a drawing task, we decoded motor performance…

Deep Brain Stimulation (DBS) stands as an effective intervention for alleviating the motor symptoms of Parkinson's disease (PD). Traditional commercial DBS devices are only able to deliver fixed-frequency periodic pulses to the basal…

We present a nonlinear data-driven Model Predictive Control (MPC) algorithm for deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). Although DBS is typically implemented in open-loop, closed-loop DBS (CLDBS) uses the…

Perceived outcomes from DBS for PD were sampled for 52 cases by surveying 46 DBS recipients and 45 carers. Post-DBS experience ranged from 10-129 months. There were significant variations in perceived outcomes over time. In some cases…

Objective: Closed-loop deep brain stimulation (DBS) may improve current clinical DBS treatment for neurological movement disorders, but control algorithms may perform differently across patients. New metrics are needed for comparing and…

More than 90% of the Parkinson Disease (PD) patients suffer from vocal disorders. Speech impairment is already indicator of PD. This study focuses on PD diagnosis through voiceprint features. In this paper, a method based on Deep Neural…

Adaptive deep brain stimulation (aDBS) has emerged as a promising treatment for Parkinson disease (PD). In aDBS, a surgically placed electrode sends dynamically altered stimuli to the brain based on neurophysiological feedback: an invasive…

Deep brain stimulation (DBS) has shown great promise toward treating motor symptoms caused by Parkinson's disease (PD), by delivering electrical pulses to the Basal Ganglia (BG) region of the brain. However, DBS devices approved by the U.S.…

Parkinson's disease (PD) is a progressive neurodegenerative disorder that impacts motor functions and speech characteristics This study focuses on differentiating individuals with Parkinson's disease from healthy controls through the…

Parkinson's Disease afflicts millions of individuals globally. Emerging as a promising brain rehabilitation therapy for Parkinson's Disease, Closed-loop Deep Brain Stimulation (CL-DBS) aims to alleviate motor symptoms. The CL-DBS system…

Multiscale modelling presents a multifaceted perspective into understanding the mechanisms of the brain and how neurodegenerative disorders like Parkinson's disease (PD) manifest and evolve over time. In this study, we propose a novel…

This paper presents the results of our recent work on studying the effects of deep brain stimulation (DBS) and medication on the dynamics of brain local field potential (LFP) signals used for behavior analysis of patients with Parkinson s…

Speech impairments are prevalent biomarkers for Parkinson's Disease (PD), motivating the development of diagnostic techniques using speech data for clinical applications. Although deep acoustic features have shown promise for PD…

Suppression of excessively synchronous beta-band oscillatory activity in the brain is believed to suppress hypokinetic motor symptoms of Parkinson's disease. Recently, a lot of interest has been devoted to desynchronizing delayed feedback…

Deep brain stimulation (DBS) is a neurosurgical procedure successfully used to treat conditions such as Parkinson's disease. Electrostimulation, carried out by implanting electrodes into an identified focus in the brain, makes it possible…

Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD…