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Stochastic modelling provides an indispensable tool for understanding how random events at the molecular level influence cellular functions. In practice, the common challenge is to calibrate a large number of model parameters against the…

分子网络 · 定量生物学 2015-03-17 Shuohao Liao , Tomas Vejchodsky , Radek Erban

We present computer-assisted methods for analyzing stochastic models of gene regulatory networks. The main idea that underlies this equation-free analysis is the design and execution of appropriately-initialized short bursts of stochastic…

生物物理 · 物理学 2009-11-11 Radek Erban , Ioannis G. Kevrekidis , David Adalsteinsson , Timothy C. Elston

High-dimensional tensor-valued predictors arise in modern applications, increasingly as learned representations from neural networks. Existing tensor classification methods rely on sparsity or Tucker structures and often lack theoretical…

机器学习 · 计算机科学 2025-12-16 Elynn Chen , Yuefeng Han , Jiayu Li

This paper describes a flexible framework for generalized low-rank tensor estimation problems that includes many important instances arising from applications in computational imaging, genomics, and network analysis. The proposed estimator…

统计理论 · 数学 2021-02-08 Rungang Han , Rebecca Willett , Anru R. Zhang

Tensor trains are a versatile tool to compress and work with high-dimensional data and functions. In this work we introduce the Streaming Tensor Train Approximation (STTA), a new class of algorithms for approximating a given tensor…

数值分析 · 数学 2022-08-05 Daniel Kressner , Bart Vandereycken , Rik Voorhaar

Many cellular behaviors are regulated by gene regulation networks, kinetics of which is one of the main subjects in the study of systems biology. Because of the low number molecules in these reacting systems, stochastic effects are…

定量方法 · 定量生物学 2011-04-26 Jinzhi Lei

In biophysics, the search for analytical solutions of stochastic models of cellular processes is often a challenging task. In recent work on models of gene expression, it was shown that a mapping based on partitioning of Poisson arrivals…

生物物理 · 物理学 2018-05-09 Hugo Tschirhart , Thierry Platini

Tensor networks such as matrix product states (MPS) and projected entangled pair states (PEPS) are commonly used to approximate quantum systems. These networks are optimized in methods such as DMRG or evolved by local operators. We provide…

数值分析 · 数学 2020-01-07 Yifan Zhang , Edgar Solomonik

We propose a novel sparse tensor decomposition method, namely Tensor Truncated Power (TTP) method, that incorporates variable selection into the estimation of decomposition components. The sparsity is achieved via an efficient truncation…

机器学习 · 统计学 2016-05-04 Will Wei Sun , Junwei Lu , Han Liu , Guang Cheng

This paper introduces a general framework of Semi-parametric TEnsor Factor Analysis (STEFA) that focuses on the methodology and theory of low-rank tensor decomposition with auxiliary covariates. Semi-parametric TEnsor Factor Analysis models…

统计方法学 · 统计学 2024-04-03 Elynn Y. Chen , Dong Xia , Chencheng Cai , Jianqing Fan

Deciphering complex gene-gene interactions remains challenging in transcriptomics as traditional methods often miss higher-order and nonlinear dependencies. This study introduces a quantum-inspired framework leveraging tensor networks (TNs)…

We study the Order-$k$ ($k \geq 4$) spiked tensor model for the tensor principal component analysis (PCA) problem: given $N$ i.i.d. observations of a $k$-th order tensor generated from the model $\mathbf{T} = \lambda \cdot v_*^{\otimes k} +…

最优化与控制 · 数学 2025-10-17 Shihong Ding , Yihong Gu , Yuanshi Liu , Cong Fang

We study the application of the novel tensor formats (TT, QTT, QTT-Tucker) to the solution of $d$-dimensional chemical master equations, applied mostly to gene regulating networks (signaling cascades, toggle switches, phage-$\lambda$). For…

数值分析 · 数学 2013-11-14 Sergey Dolgov , Boris Khoromskij

High-dimensional tensors or multi-way data are becoming prevalent in areas such as biomedical imaging, chemometrics, networking and bibliometrics. Traditional approaches to finding lower dimensional representations of tensor data include…

机器学习 · 统计学 2012-02-14 Genevera I. Allen

Modeling joint probability distributions over sequences has been studied from many perspectives. The physics community developed matrix product states, a tensor-train decomposition for probabilistic modeling, motivated by the need to…

机器学习 · 计算机科学 2020-10-22 Siddarth Srinivasan , Sandesh Adhikary , Jacob Miller , Guillaume Rabusseau , Byron Boots

Statistical inference for tensors has emerged as a critical challenge in analyzing high-dimensional data in modern data science. This paper introduces a unified framework for inferring general and low-Tucker-rank linear functionals of…

统计理论 · 数学 2025-01-28 Ke Xu , Elynn Chen , Yuefeng Han

In this work, we perform Bayesian inference tasks for the chemical master equation in the tensor-train format. The tensor-train approximation has been proven to be very efficient in representing high dimensional data arising from the…

There has been an increasing demand for formal methods in the design process of safety-critical synthetic genetic circuits. Probabilistic model checking techniques have demonstrated significant potential in analyzing the intrinsic…

新兴技术 · 计算机科学 2019-01-24 Thakur Neupane , Zhen Zhang , Curtis Madsen , Hao Zheng , Chris J. Myers

Online transient stability assessment (TSA) is essential for secure and stable power system operations. The growing number of Phasor Measurement Units (PMUs) brings about massive sources of data that can enhance online TSA. However,…

系统与控制 · 电气工程与系统科学 2021-12-16 Rui Ma , Sara Eftekharnejad , Chen Zhong , Mustafa Cenk Gursoy

Tensor train is a hierarchical tensor network structure that helps alleviate the curse of dimensionality by parameterizing large-scale multidimensional data via a set of network of low-rank tensors. Associated with such a construction is a…

机器学习 · 计算机科学 2018-03-15 Wenqi Wang , Vaneet Aggarwal , Shuchin Aeron
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