相关论文: Design and analysis considerations for a sequentia…
The Drinkers' Intervention to Prevent TB (DIPT) is a randomized controlled trial designed to determine if incentive-based approaches can reduce alcohol use and improve medication adherence to isoniazid (INH) preventive therapy in persons…
With the launch of second line anti-retroviral therapy for HIV infected individuals, there has been an increased expectation on surviving period of people with HIV. We consider previously well-known models in HIV epidemiology where the…
Technology-facilitated abuse (TFA) is a pervasive form of intimate partner violence (IPV) that leverages digital tools to control, surveil, or harm survivors. While tech clinics are one of the reliable sources of support for TFA survivors,…
Reverse engineering is a complex process essential to software-security tasks such as vulnerability discovery and malware analysis. Significant research and engineering effort has gone into developing tools to support reverse engineers.…
Background: Sequential positivity is often a necessary assumption for drawing causal inferences, such as through marginal structural modeling. Unfortunately, verification of this assumption can be challenging because it usually relies on…
The last two centuries saw groundbreaking advances in the field of healthcare: from the invention of the vaccine to organ transplant, and eradication of numerous deadly diseases. Yet, these breakthroughs have only illuminated the role that…
With the rapid diffusion of social networks in combination with mobile phones, a new social threat of sextortion has emerged, in which vulnerable young women are essentially blackmailed with their explicit shared multimedia content. The…
Chronic infections of the human immunodeficiency virus (HIV) create a very complex co-evolutionary process, where the virus tries to escape the continuously adapting host immune system. Quantitative details of this process are largely…
This study protocol outlines the design and methodology of a research study investigating collaborative game elements to promote physical activity within digital health interventions. The study aims to examine how social relatedness…
Respondent-driven sampling (RDS) is a widely used method for sampling from hard-to-reach human populations, especially groups most at-risk for HIV/AIDS. Data are collected through a peer-referral process in which current sample members…
Due to the heterogeneity of the randomized controlled trial (RCT) and external target populations, the estimated treatment effect from the RCT is not directly applicable to the target population. For example, the patient characteristics of…
HIV is a retrovirus that attacks the human immune system and can lead to death without proper treatment. In collaboration with the WHO and Wits University, we study how to improve the efficiency of HIV testing with the goal of eventual…
Randomized experiments often need to be stopped prematurely due to the treatment having an unintended harmful effect. Existing methods that determine when to stop an experiment early are typically applied to the data in aggregate and do not…
We present the design of an online social skills development interface for teenagers with autism spectrum disorder (ASD). The interface is intended to enable private conversation practice anywhere, anytime using a web-browser. Users…
There is a growing interest in the implementation of platform trials, which provide the flexibility to incorporate new treatment arms during the trial and the ability to halt treatments early based on lack of benefit or observed…
The sequential multiple assignment randomized trial (SMART) is the gold standard trial design to generate data for the evaluation of multi-stage treatment regimes. As with conventional (single-stage) randomized clinical trials, interim…
In the group testing problem we aim to identify a small number of infected individuals within a large population. We avail ourselves to a procedure that can test a group of multiple individuals, with the test result coming out positive iff…
Momentum-resolved scanning transmission electron microscopy (MRSTEM) is a powerful phase-contrast technique that can map lateral magnetic and electric fields ranging from the micrometer to the subatomic scale. Resolving fields ranging from…
From incorporating LLMs in education, to identifying new drugs and improving ways to charge batteries, innovators constantly try new strategies in search of better long-term outcomes for students, patients and consumers. One major…
Group sequential designs (GSDs) are well established and the most commonly used adaptive design in confirmatory clinical trials with interim analyses. However, they remain underutilised, and their implementation involves unique theoretical…