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相关论文: Estimating Individualized Treatment Regimes from C…

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Estimating individualized treatment rules (ITRs) is crucial for tailoring interventions in precision medicine. Typical ITR estimation methods rely on conditional average treatment effects (CATEs) to guide treatment assignments. However,…

统计方法学 · 统计学 2025-10-20 Peng Wu , Qing Jiang , Shanshan Luo , Zhi Geng

Randomized controlled trials typically analyze the effectiveness of treatments with the goal of making treatment recommendations for patient subgroups. With the advance of electronic health records, a great variety of data has been…

机器学习 · 计算机科学 2021-03-31 Zhiliang Wu , Yinchong Yang , Yunpu Ma , Yushan Liu , Rui Zhao , Michael Moor , Volker Tresp

Recent development in the data-driven decision science has seen great advances in individualized decision making. Given data with individual covariates, treatment assignments and outcomes, policy makers best individualized treatment rule…

机器学习 · 统计学 2020-06-29 Weibin Mo , Zhengling Qi , Yufeng Liu

An individualized decision rule (IDR) is a decision function that assigns each individual a given treatment based on his/her observed characteristics. Most of the existing works in the literature consider settings with binary or finitely…

统计方法学 · 统计学 2023-01-31 Hengrui Cai , Chengchun Shi , Rui Song , Wenbin Lu

In many important applications of precision medicine, the outcome of interest is time to an event (e.g., death, relapse of disease) and the primary goal is to identify the optimal individualized decision rule (IDR) to prolong survival time.…

统计方法学 · 统计学 2022-04-11 Yu Zhou , Lan Wang , Rui Song , Tuoyi Zhao

Individualized treatment rules (ITRs) have been widely applied in many fields such as precision medicine and personalized marketing. Beyond the extensive studies on ITR for binary or multiple treatments, there is considerable interest in…

统计方法学 · 统计学 2024-03-08 Qi Xu , Xiaoke Cao , Geping Chen , Hanqi Zeng , Haoda Fu , Annie Qu

Precision medicine leverages patient heterogeneity to estimate individualized treatment regimens, formalized, data-driven approaches designed to match patients with optimal treatments. In the presence of competing events, where multiple…

统计方法学 · 统计学 2024-11-14 Christina W. Zhou , Nikki L. B. Freeman , Katharine L. McGinigle , Michael R. Kosorok

Although there is now a large literature on policy evaluation and learning, much of the prior work assumes that the treatment assignment of one unit does not affect the outcome of another unit. Unfortunately, ignoring interference can lead…

统计方法学 · 统计学 2025-04-02 Yi Zhang , Kosuke Imai

Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular. The data collected during randomized clinical…

统计方法学 · 统计学 2015-06-30 Stanislav Minsker , Ying-Qi Zhao , Guang Cheng

Individualized treatment regimes (ITRs) aim to improve clinical outcomes by assigning treatment based on patient-specific characteristics. However, existing methods often struggle with high-dimensional covariates, limiting accuracy,…

机器学习 · 统计学 2026-01-13 Sungtaek Son , Eardi Lila , Kwun Chuen Gary Chan

Identifying patients who benefit from a treatment is a key aspect of personalized medicine, which allows the development of individualized treatment rules (ITRs). Many machine learning methods have been proposed to create such rules.…

An individualized treatment regime (ITR) is a decision rule that assigns treatments based on patients' characteristics. The value function of an ITR is the expected outcome in a counterfactual world had this ITR been implemented. Recently,…

统计方法学 · 统计学 2023-01-16 Pan Zhao , Julie Josse , Shu Yang

In precision medicine, Dynamic Treatment Regimes (DTRs) are treatment protocols that adapt over time in response to a patient's observed characteristics. A DTR is a set of decision functions that takes an individual patient's information as…

统计方法学 · 统计学 2022-03-17 Cong Jiang , Michael Wallace , Mary Thompson

Personalized decision-making, tailored to individual characteristics, is gaining significant attention. The optimal treatment regime aims to provide the best-expected outcome in the entire population, known as the value function. One…

统计方法学 · 统计学 2024-05-28 Yuwen Cheng , Shu Yang

Precision medicine seeks to discover an optimal personalized treatment plan and thereby provide informed and principled decision support, based on the characteristics of individual patients. With recent advancements in medical imaging, it…

统计方法学 · 统计学 2023-04-26 Xinyi Li , Michael R. Kosorok

An optimal dynamic treatment regime (DTR) is a sequence of decision rules aimed at providing the best course of treatments individualized to patients. While conventional DTR estimation uses longitudinal data, such data can also be…

统计方法学 · 统计学 2025-02-06 Larry Dong , Eleanor Pullenayegum , Rodolphe Thiébaut , Olli Saarela

Estimating individualized treatment rules (ITRs) is fundamental to precision medicine, where the goal is to tailor treatment decisions to individual patient characteristics. While numerous methods have been developed for ITR estimation,…

统计方法学 · 统计学 2026-05-15 Eun Jeong Oh , Min Qian

With the emergence of precision medicine, estimating optimal individualized decision rules (IDRs) has attracted tremendous attention in many scientific areas. Most existing literature has focused on finding optimal IDRs that can maximize…

统计方法学 · 统计学 2022-06-28 Zhengling Qi , Jong-Shi Pang , Yufeng Liu

Individualized treatment rules (ITRs) aim to optimize healthcare by tailoring treatment decisions to patient-specific characteristics. Existing methods typically rely on either interpretable but inflexible models or highly flexible…

统计方法学 · 统计学 2026-02-13 Yasin Khadem Charvadeh , Katherine S. Panageas , Yuan Chen

Integrative analysis of multiple datasets for estimating optimal individualized treatment rules (ITRs) can enhance decision efficiency. A central challenge is posterior shift, wherein the conditional distribution of potential outcomes given…

机器学习 · 统计学 2026-03-09 Wenhai Cui , Wen Su , Xingqiu Zhao