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Cancer is a heterogeneous disease with diverse molecular etiologies and outcomes. The Cancer Genome Atlas (TCGA) has released a large compendium of over 10,000 tumors with RNA-seq gene expression measurements. Gene expression captures the…

基因组学 · 定量生物学 2017-11-15 Gregory P. Way , Casey S. Greene

Domain shift is a problem commonly encountered when developing automated histopathology pipelines. The performance of machine learning models such as convolutional neural networks within automated histopathology pipelines is often…

图像与视频处理 · 电气工程与系统科学 2021-07-16 Andrew Moyes , Richard Gault , Kun Zhang , Ji Ming , Danny Crookes , Jing Wang

Large amounts of unlabelled data are commonplace for many applications in computational pathology, whereas labelled data is often expensive, both in time and cost, to acquire. We investigate the performance of unsupervised and supervised…

计算机视觉与模式识别 · 计算机科学 2019-07-27 Koen Dercksen , Wouter Bulten , Geert Litjens

Background and Purpose: Colorectal cancer is a common fatal malignancy, the fourth most common cancer in men, and the third most common cancer in women worldwide. Timely detection of cancer in its early stages is essential for treating the…

This paper proposes an autoencoder (AE) that is used for improving the performance of once-class classifiers for the purpose of detecting anomalies. Traditional one-class classifiers (OCCs) perform poorly under certain conditions such as…

机器学习 · 计算机科学 2020-01-01 Kasra Babaei , ZhiYuan Chen , Tomas Maul

Digital pathology has seen the advent of a wealth of foundational models (FM), yet to date their performance on cell phenotyping has not been benchmarked in a unified manner. We therefore propose PhenoBench: A comprehensive benchmark for…

Current methods for diagnosing the progression of multiple types of cancer within patients rely on interpreting stained needle biopsies. This process is time-consuming and susceptible to error throughout the paraffinization, Hematoxylin and…

图像与视频处理 · 电气工程与系统科学 2022-04-19 Benjamin Paulson , Theodore Colwell , Natalia Bukowski , Joseph Weller , Andrew Crisler , John Cisler , Alexander Drobek , Alexander Neuwirth

With the increasing use of high-precision system analysis programs in nuclear engineering, the number of high-fidelity computational data for accident simulation is exploding. Therefore, an algorithm that can achieve both automatic…

信号处理 · 电气工程与系统科学 2022-08-30 Chengyuan Li , Meifu Li , Zhifang Qiu

One of the methods for stratifying different molecular classes of breast cancer is the Nottingham Prognostic Index Plus (NPI+) which uses breast cancer relevant biomarkers to stain tumour tissues prepared on tissue microarray (TMA). To…

计算机视觉与模式识别 · 计算机科学 2019-01-15 Jingxin Liu , Bolei Xu , Chi Zheng , Yuanhao Gong , Jon Garibaldi , Daniele Soria , Andew Green , Ian O. Ellis , Wenbin Zou , Guoping Qiu

Breast cancer presents a significant healthcare challenge globally, demanding precise diagnostics and effective treatment strategies, where histopathological examination of Hematoxylin and Eosin (H&E) stained tissue sections plays a central…

图像与视频处理 · 电气工程与系统科学 2024-08-06 Linhao Qu , Chengsheng Zhang , Guihui Li , Haiyong Zheng , Chen Peng , Wei He

The aim of this study is to propose and evaluate an advanced ransomware detection and classification method that combines a Stacked Autoencoder (SAE) for precise feature selection with a Long Short Term Memory (LSTM) classifier to enhance…

机器学习 · 计算机科学 2024-04-24 Mike Nkongolo , Mahmut Tokmak

Classical machine learning often struggles with complex, high-dimensional data. Quantum machine learning offers a potential solution, promising more efficient processing. The quantum convolutional neural network (QCNN), a hybrid algorithm,…

量子物理 · 物理学 2025-07-25 Hinako Asaoka , Kazue Kudo

This paper presents a novel convolutional neural network (CNN) based image compression framework via scalable auto-encoder (SAE). Specifically, our SAE based deep image codec consists of hierarchical coding layers, each of which is an…

多媒体 · 计算机科学 2019-04-02 Chuanmin Jia , Zhaoyi Liu , Yao Wang , Siwei Ma , Wen Gao

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

计算机视觉与模式识别 · 计算机科学 2021-11-30 Simon Graham , Mostafa Jahanifar , Quoc Dang Vu , Giorgos Hadjigeorghiou , Thomas Leech , David Snead , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

Breast cancer is one of the most common causes of cancer-related death in women worldwide. Early and accurate diagnosis of breast cancer may significantly increase the survival rate of patients. In this study, we aim to develop a fully…

图像与视频处理 · 电气工程与系统科学 2019-09-27 Sara Hosseinzadeh Kassani , Peyman Hosseinzadeh Kassani , Michal J. Wesolowski , Kevin A. Schneider , Ralph Deters

Patient-derived extracellular vesicles (EVs) that contains a complex biological cargo is a valuable source of liquid biopsy diagnostics to aid in early detection, cancer screening, and precision nanotherapeutics. In this study, we predicted…

Cancer is a complex disease with significant social and economic impact. Advancements in high-throughput molecular assays and the reduced cost for performing high-quality multi-omics measurements have fuelled insights through machine…

机器学习 · 计算机科学 2022-06-28 Pedro Henrique da Costa Avelar , Roman Laddach , Sophia Karagiannis , Min Wu , Sophia Tsoka

Advancements in optical quantum technologies have been enabled by the generation, manipulation, and characterization of light, with identification based on its photon statistics. However, characterizing light and its sources through single…

量子物理 · 物理学 2024-05-09 Mahesh Bhupati , Abhishek Mall , Anshuman Kumar , Pankaj K. Jha

Molecular and genomic properties are critical in selecting cancer treatments to target individual tumors, particularly for immunotherapy. However, the methods to assess such properties are expensive, time-consuming, and often not routinely…

图像与视频处理 · 电气工程与系统科学 2022-11-29 Heather D. Couture

Masked Autoencoders (MAEs) have emerged as a dominant strategy for self-supervised representation learning in natural images, where models are pre-trained to reconstruct masked patches with a pixel-wise mean squared error (MSE) between…

图像与视频处理 · 电气工程与系统科学 2025-07-16 Chetan Madan , Aarjav Satia , Soumen Basu , Pankaj Gupta , Usha Dutta , Chetan Arora