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In the present study, we propose a novel case-based similar image retrieval (SIR) method for hematoxylin and eosin (H&E)-stained histopathological images of malignant lymphoma. When a whole slide image (WSI) is used as an input query, it is…

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

计算机视觉与模式识别 · 计算机科学 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Computer-aided diagnosis (CAD) can be used as an important tool to aid and enhance pathologists' diagnostic decision-making. Deep learning techniques, such as convolutional neural networks (CNN) and fully convolutional networks (FCN), have…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Dalí F. D. dos Santos , Paulo R. de Faria , Adriano M. Loyola , Sérgio V. Cardoso , Bruno A. N. Travençolo , Marcelo Z. do Nascimento

Automatic detection of lymphocyte in H&E images is a necessary first step in lots of tissue image analysis algorithms. An accurate and robust automated lymphocyte detection approach is of great importance in both computer science and…

计算机视觉与模式识别 · 计算机科学 2016-12-13 Jianxu Chen , Chukka Srinivas

Nuclei instance segmentation is crucial in oncological diagnosis and cancer pathology research. H&E stained images are commonly used for medical diagnosis, but pre-processing is necessary before using them for image processing tasks. Two…

图像与视频处理 · 电气工程与系统科学 2024-04-22 Zarif Ahmed , Chowdhury Nur E Alam Siddiqi , Fardifa Fathmiul Alam , Tasnim Ahmed , Tareque Mohmud Chowdhury

Despite the increasing use of deep learning in medical image segmentation, acquiring sufficient training data remains a challenge in the medical field. In response, data augmentation techniques have been proposed; however, the generation of…

图像与视频处理 · 电气工程与系统科学 2024-06-11 Aghiles Kebaili , Jérôme Lapuyade-Lahorgue , Pierre Vera , Su Ruan

Diagnosis of breast carcinomas has so far been limited to the morphological interpretation of epithelial cells and the assessment of epithelial tissue architecture. Consequently, most of the automated systems have focused on characterizing…

We present Deep Compression Autoencoder (DC-AE), a new family of autoencoder models for accelerating high-resolution diffusion models. Existing autoencoder models have demonstrated impressive results at a moderate spatial compression ratio…

计算机视觉与模式识别 · 计算机科学 2025-05-20 Junyu Chen , Han Cai , Junsong Chen , Enze Xie , Shang Yang , Haotian Tang , Muyang Li , Yao Lu , Song Han

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

图像与视频处理 · 电气工程与系统科学 2022-02-25 Satoshi Kondo , Satoshi Kasai

The interactions between tumor cells and the tumor microenvironment (TME) dictate therapeutic efficacy of radiation and many systemic therapies in breast cancer. However, to date, there is not a widely available method to reproducibly…

The accurate classification of lymphoma subtypes using hematoxylin and eosin (H&E)-stained tissue is complicated by the wide range of morphological features these cancers can exhibit. We present LymphoML - an interpretable machine learning…

Early diagnosis of the cancer cells is necessary for making an effective treatment plan and for the health and safety of a patient. Nowadays, doctors usually use a histological grade that pathologists determine by performing a…

计算机视觉与模式识别 · 计算机科学 2023-11-15 Varan Singh Rohila , Neeraj Lalwani , Lochan Basyal

Effective treatment for rectal cancer relies on accurate lymph node metastasis (LNM) staging. However, radiological criteria based on lymph node (LN) size, shape and texture morphology have limited diagnostic accuracy. In this work, we…

计算机视觉与模式识别 · 计算机科学 2025-07-17 Benjamin Keel , Aaron Quyn , David Jayne , Maryam Mohsin , Samuel D. Relton

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Biomedical imaging and RNA sequencing with single-cell resolution improves our understanding of white blood cell diseases like leukemia. By combining morphological and transcriptomic data, we can gain insights into cellular functions and…

计算机视觉与模式识别 · 计算机科学 2024-08-26 Gizem Mert , Ario Sadafi , Raheleh Salehi , Nassir Navab , Carsten Marr

In this paper, we demonstrate the potential of applying Variational Autoencoder (VAE) [10] for anomaly detection in skin disease images. VAE is a class of deep generative models which is trained by maximizing the evidence lower bound of…

机器学习 · 计算机科学 2018-07-26 Yuchen Lu , Peng Xu

This work contributes to breast cancer sub-type classification using histopathological images. We utilize masked autoencoders (MAEs) to learn a self-supervised embedding tailored for computer vision tasks in this domain. This embedding…

计算机视觉与模式识别 · 计算机科学 2025-06-10 Annalisa Chiocchetti , Marco Dossena , Christopher Irwin , Luigi Portinale

Defining and separating cancer subtypes is essential for facilitating personalized therapy modality and prognosis of patients. The definition of subtypes has been constantly recalibrated as a result of our deepened understanding. During…

机器学习 · 计算机科学 2022-07-21 Zheng Chen , Ziwei Yang , Lingwei Zhu , Guang Shi , Kun Yue , Takashi Matsubara , Shigehiko Kanaya , MD Altaf-Ul-Amin

The objective assessment of image quality (IQ) has been advocated for the analysis and optimization of medical imaging systems. One method of obtaining such IQ metrics is through a mathematical observer. The Bayesian ideal observer is…

信号处理 · 电气工程与系统科学 2025-08-19 Jason L. Granstedt , Weimin Zhou , Mark A. Anastasio

Melanoma is the most lethal form of skin cancer, with an increasing incidence rate worldwide. Analyzing histological images of melanoma by localizing and classifying tissues and cell nuclei is considered the gold standard method for…

计算机视觉与模式识别 · 计算机科学 2025-09-03 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod