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The distribution and appearance of nuclei are essential markers for the diagnosis and study of cancer. Despite the importance of nuclear morphology, there is a lack of large scale, accurate, publicly accessible nucleus segmentation data. To…

图像与视频处理 · 电气工程与系统科学 2020-12-02 Le Hou , Rajarsi Gupta , John S. Van Arnam , Yuwei Zhang , Kaustubh Sivalenka , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

Numerous deep learning based methods have been developed for nuclei segmentation for H&E images and have achieved close to human performance. However, direct application of such methods to another modality of images, such as…

计算机视觉与模式识别 · 计算机科学 2022-08-15 Roger Trullo , Quoc-Anh Bui , Qi Tang , Reza Olfati-Saber

Feature selection reduces the dimensionality of data by identifying a subset of the most informative features. In this paper, we propose an innovative framework for unsupervised feature selection, called fractal autoencoders (FAE). It…

机器学习 · 计算机科学 2022-01-06 Xinxing Wu , Qiang Cheng

Chest X-Ray (CXR) is one of the most common diagnostic techniques used in everyday clinical practice all around the world. We hereby present a work which intends to investigate and analyse the use of Deep Learning (DL) techniques to extract…

图像与视频处理 · 电气工程与系统科学 2024-07-16 Leonardo Crespi , Daniele Loiacono , Arturo Chiti

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

图像与视频处理 · 电气工程与系统科学 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…

图像与视频处理 · 电气工程与系统科学 2022-01-20 Niccoló Marini , Manfredo Atzori , Sebastian Otálora , Stephane Marchand-Maillet , Henning Müller

Integrating the different data modalities of cancer patients can significantly improve the predictive performance of patient survival. However, most existing methods ignore the simultaneous utilization of rich semantic features at different…

计算机视觉与模式识别 · 计算机科学 2024-05-14 Liangrui Pan , Yijun Peng , Yan Li , Yiyi Liang , Liwen Xu , Qingchun Liang , Shaoliang Peng

Mutational signature analysis has emerged as a powerful method for uncovering the underlying biological processes driving cancer development. However, the signature extraction process, typically performed using non-negative matrix…

Unsupervised segmentation approaches have increasingly leveraged foundation models (FM) to improve salient object discovery. However, these methods often falter in scenes with complex, multi-component morphologies, where fine-grained…

计算机视觉与模式识别 · 计算机科学 2026-04-02 Deepank Singh , Anurag Nihal , Vedhus Hoskere

Molecular testing of tumor samples for targetable biomarkers is restricted by a lack of standardization, turnaround-time, cost, and tissue availability across cancer types. Additionally, targetable alterations of low prevalence may not be…

计算机视觉与模式识别 · 计算机科学 2024-07-23 Kshitij Ingale , Sun Hae Hong , Qiyuan Hu , Renyu Zhang , Bo Osinski , Mina Khoshdeli , Josh Och , Kunal Nagpal , Martin C. Stumpe , Rohan P. Joshi

Accurate segmentation and classification of nuclei in histology images is critical but challenging due to nuclei heterogeneity, staining variations, and tissue complexity. Existing methods often struggle with limited dataset variability,…

图像与视频处理 · 电气工程与系统科学 2025-01-22 Wenhua Zhang , Sen Yang , Meiwei Luo , Chuan He , Yuchen Li , Jun Zhang , Xiyue Wang , Fang Wang

Stack autoencoder (SAE), as a representative deep network, has unique and excellent performance in feature learning, and has received extensive attention from researchers. However, existing deep SAEs focus on original samples without…

机器学习 · 计算机科学 2022-10-28 Chuanyan Zhou , Jie Ma , Fan Li , Yongming Li , Pin Wang , Xiaoheng Zhang

Developing an AI-assisted gland segmentation method from histology images is critical for automatic cancer diagnosis and prognosis; however, the high cost of pixel-level annotations hinders its applications to broader diseases. Existing…

计算机视觉与模式识别 · 计算机科学 2022-06-28 Yi Li , Yiduo Yu , Yiwen Zou , Tianqi Xiang , Xiaomeng Li

Development of robust and accurate fully automated methods for medical image segmentation is crucial in clinical practice and radiomics studies. In this work, we contributed an automated approach for Head and Neck (H&N) primary tumor…

图像与视频处理 · 电气工程与系统科学 2021-02-23 Andrei Iantsen , Dimitris Visvikis , Mathieu Hatt

In this paper, we propose a novel, effective and simpler end-to-end image clustering auto-encoder algorithm: ICAE. The algorithm uses PEDCC (Predefined Evenly-Distributed Class Centroids) as the clustering centers, which ensures the…

计算机视觉与模式识别 · 计算机科学 2021-08-24 Qiuyu Zhu , Zhengyong Wang

Significance: Histopathological analysis of tissues is an essential tool for grading, staging, diagnosing and resecting cancers and other malignancies. Current histopathological techniques require substantial sample processing prior to…

医学物理 · 物理学 2021-07-14 Benjamin Ecclestone , Deepak Dinakaran , Parsin Haji Reza

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

组织与器官 · 定量生物学 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

Automatic image segmentation technology is critical to the visual analysis. The autoencoder architecture has satisfying performance in various image segmentation tasks. However, autoencoders based on convolutional neural networks (CNN) seem…

计算机视觉与模式识别 · 计算机科学 2022-08-22 Shiqiang Ma , Xuejian Li , Jijun Tang , Fei Guo

Diagnosis and treatment management for head and neck squamous cell carcinoma (HNSCC) is guided by routine diagnostic head and neck computed tomography (CT) scans to identify tumor and lymph node features. Extracapsular extension (ECE) is a…

图像与视频处理 · 电气工程与系统科学 2025-09-12 Yibin Wang , Abdur Rahman , W. Neil. Duggar , P. Russell Roberts , Toms V. Thomas , Linkan Bian , Haifeng Wang

Automatization of the diagnosis of any kind of disease is of great importance and it's gaining speed as more and more deep learning solutions are applied to different problems. One of such computer aided systems could be a decision support…

计算机视觉与模式识别 · 计算机科学 2018-04-24 Tomas Iesmantas , Robertas Alzbutas