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The aim of this article is to introduce a reporting framework for reproducible, interactive research applied to Big Clinical Data, based on open source technologies. The framework is constituted by the following three axes: (i) data, (ii)…

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction networks integrating…

Artificial intelligence (AI) in the form of deep learning bears promise for drug discovery and chemical biology, $\textit{e.g.}$, to predict protein structure and molecular bioactivity, plan organic synthesis, and design molecules…

生物大分子 · 定量生物学 2022-12-29 Rıza Özçelik , Derek van Tilborg , José Jiménez-Luna , Francesca Grisoni

This paper outlines a conceptual framework for understanding recent developments in information retrieval and natural language processing that attempts to integrate dense and sparse retrieval methods. I propose a representational approach…

信息检索 · 计算机科学 2021-12-30 Jimmy Lin

In the present paper, we propose a Neuroelectromagnetic Ontology Framework (NOF) for mining Event-related Potentials (ERP) patterns as well as the process. The aim for this research is to develop an infrastructure for mining, analysis and…

Recommender systems learn about user preferences over time, automatically finding things of similar interest. This reduces the burden of creating explicit queries. Recommender systems do, however, suffer from cold-start problems where no…

机器学习 · 计算机科学 2007-05-23 Stuart E. Middleton , Harith Alani , David C. De Roure

Relational and noSQL storages are developed for the fast processing of the large data sets having a stable structure, while the ontologies are used to rep-resent complex and dynamic sets of information of a limited size. In the in-dustrial…

数据库 · 计算机科学 2021-03-10 Sergey Gorshkov , Alexander Grebeshkov , Roman Shebalov

This essay is based on the joint project with 111, Inc. The pharmacy e-Commerce business grows rapidly in recent years with the ever-increasing medical demand during the pandemic. A big challenge for online pharmacy platforms is drug…

人工智能 · 计算机科学 2022-07-05 Dong Chenxi , QP Zhang , B Hu , JC Zhang , Dl Lin

Current work in named entity recognition (NER) shows that data augmentation techniques can produce more robust models. However, most existing techniques focus on augmenting in-domain data in low-resource scenarios where annotated data is…

计算与语言 · 计算机科学 2021-09-07 Shuguang Chen , Gustavo Aguilar , Leonardo Neves , Thamar Solorio

Complex information needs may involve set-compositional queries using conjunction, disjunction, and exclusion, yet it remains unclear whether current retrieval paradigms genuinely satisfy such constraints or exploit `semantic shortcuts'. We…

计算与语言 · 计算机科学 2026-05-07 Vincent Degenhart , Dewi Timman , Arjen P. de Vries , Faegheh Hasibi , Mohanna Hoveyda

This paper presents an ontology-driven treatment article retrieval system developed and experimented using the data and ground truths provided by the TREC 2017 precision medicine track. The key aspects of our system include: meaningful…

Retrieval systems are essential to contemporary AI pipelines, although most confuse two separate processes: finding relevant information and giving enough context for reasoning. We introduce the Search-Is-Not-Retrieve (SINR) framework, a…

信息检索 · 计算机科学 2025-11-14 Harshit Nainwani , Hediyeh Baban

High-throughput computational materials design promises to greatly accelerate the process of discovering new materials and compounds, and of optimizing their properties. The large databases of structures and properties that result from…

化学物理 · 物理学 2016-11-22 Sandip De , Felix Musil , Teresa Ingram , Carsten Baldauf , Michele Ceriotti

Reservoir computing is a type of a recurrent neural network, mapping the inputs into higher dimensional space using fixed and nonlinear dynamical systems, called reservoirs. In the literature, there are various types of reservoirs ranging…

计算工程、金融与科学 · 计算机科学 2025-06-06 Mehmet Aziz Yirik , Jakob Lykke Andersen , Rolf Fagerberg , Daniel Merkle

A standard model for exposing structured provenance metadata of scientific assertions on the Semantic Web would increase interoperability, discoverability, reliability, as well as reproducibility for scientific discourse and evidence-based…

The prediction modeling of drug-target interactions is crucial to drug discovery and design, which has seen rapid advancements owing to deep learning technologies. Recently developed methods, such as those based on graph neural networks…

定量方法 · 定量生物学 2025-11-19 Xinnan Zhang , Jialin Wu , Junyi Xie , Tianlong Chen , Kaixiong Zhou

Predicting the novel effects of drugs based on information about approved drugs can be regarded as a recommendation system. Matrix factorization is one of the most used recommendation systems and various algorithms have been devised for it.…

定量方法 · 定量生物学 2023-01-16 Iori Azuma , Tadahaya Mizuno , Hiroyuki Kusuhara

Generative retrieval constitutes an innovative approach in information retrieval, leveraging generative language models (LM) to generate a ranked list of document identifiers (docid) for a given query. It simplifies the retrieval pipeline…

信息检索 · 计算机科学 2025-02-13 Penghao Lu , Xin Dong , Yuansheng Zhou , Lei Cheng , Chuan Yuan , Linjian Mo

This paper addresses the challenge of improving information retrieval from semi-structured eXtensible Markup Language (XML) documents. Traditional information retrieval systems (IRS) often overlook user-specific needs and return identical…

信息检索 · 计算机科学 2026-03-24 Ounnaci Iddir , Ahmed-ouamer Rachid , Tai Dinh

The importance of improving the FAIRness (findability, accessibility, interoperability, reusability) of research data is undeniable, especially in the face of large, complex datasets currently being produced by omics technologies.…