To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction networks integrating the top ranked host factors, drug target proteins, and directed protein-protein interaction data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.
@article{arxiv.2106.12297,
title = {Network analytics for drug repurposing in COVID-19},
author = {Nicoleta Siminea and Victor Popescu and Jose Angel Sanchez Martin and Daniela Florea and Georgiana Gavril and Ana-Maria Gheorghe and Corina Itcus and Krishna Kanhaiya and Octavian Pacioglu and Laura Ioana Popa and Romica Trandafir and Maria Iris Tusa and Manuela Sidoroff and Mihaela Paun and Eugen Czeizler and Andrei Paun and Ion Petre},
journal= {arXiv preprint arXiv:2106.12297},
year = {2021}
}
Comments
21 pages, 3 tables, 9 figures, supplementary information included at the end, 4 files as supplementary material