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We review standard mediation assumptions as they apply to identifying antibody effects in a randomized vaccine trial and propose new study designs to allow identification of an estimand that was previously unidentifiable. For these…

统计方法学 · 统计学 2024-06-11 Michael P. Fay , Dean A. Follmann

We present a randomization-based inferential framework for experiments characterized by a strongly ignorable assignment mechanism where units have independent probabilities of receiving treatment. Previous works on randomization tests often…

统计方法学 · 统计学 2019-02-01 Zach Branson , Marie-Abele Bind

In this work, we are interested in studying the causal effect of an endogenous binary treatment on a dependently censored duration outcome. By dependent censoring, it is meant that the duration time ($T$) and right censoring time ($C$) are…

计量经济学 · 经济学 2025-04-04 Gilles Crommen , Jad Beyhum , Ingrid Van Keilegom

Clinical trials traditionally employ blinding as a design mechanism to reduce the influence of placebo effects. In practice, however, it can be difficult or impossible to blind study participants and unblinded trials are common in medical…

应用统计 · 统计学 2016-06-22 Elias Chaibub Neto

In clinical studies, the risk of the primary (terminal) event may be modified by intermediate events, resulting in semicompeting risks. To study the treatment effect on the terminal event mediated by the intermediate event, researchers wish…

统计方法学 · 统计学 2026-05-26 Yuhao Deng , Rui Wang , Tao Zhang , Xiang Zhan

In the absence of randomized controlled and natural experiments, it is necessary to balance the distributions of (observable) covariates of the treated and control groups in order to obtain an unbiased estimate of a causal effect of…

统计方法学 · 统计学 2022-03-02 Martin Cousineau , Vedat Verter , Susan A. Murphy , Joelle Pineau

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing…

统计方法学 · 统计学 2020-02-10 Liuyi Yao , Zhixuan Chu , Sheng Li , Yaliang Li , Jing Gao , Aidong Zhang

The problem of how to best select variables for confounding adjustment forms one of the key challenges in the evaluation of exposure effects in observational studies, and has been the subject of vigorous recent activity in causal inference.…

统计方法学 · 统计学 2021-12-02 Kelly Van Lancker , Oliver Dukes , Stijn Vansteelandt

In this paper we consider a time-to-event variable $T$ that is subject to random right censoring, and we assume that the censoring time $C$ is stochastically dependent on $T$ and that there is a positive probability of not observing the…

统计方法学 · 统计学 2024-03-14 Morine Delhelle , Ingrid Van Keilegom

Causal inference deals with identifying which random variables "cause" or control other random variables. Recent advances on the topic of causal inference based on tools from statistical estimation and machine learning have resulted in…

机器学习 · 统计学 2016-08-23 Matt J. Kusner , Yu Sun , Karthik Sridharan , Kilian Q. Weinberger

When there is interference, a subject's outcome depends on the treatment of others and treatment effects may take on several different forms. This situation arises often, particularly in vaccine evaluation. In settings where interference is…

统计理论 · 数学 2020-01-10 Erin E Gabriel

Many sequential decision settings in healthcare feature funnel structures characterized by a series of stages, such as screenings or evaluations, where the number of patients who advance to each stage progressively decreases and decisions…

机器学习 · 计算机科学 2025-11-25 Shuvom Sadhuka , Sophia Lin , Bonnie Berger , Emma Pierson

In contrast to problems of interference in (exogenous) treatments, models of interference in unit-specific (endogenous) outcomes do not usually produce a reduced-form representation where outcomes depend on other units' treatment status…

计量经济学 · 经济学 2025-06-17 Konrad Menzel

The micro-randomized trial (MRT) is an experimental design that can be used to develop optimal mobile health interventions. In MRTs, interventions in the form of notifications or messages are sent through smart phones to individuals,…

统计方法学 · 统计学 2022-02-14 Shuangning Li , Stefan Wager

Experimentation is widely utilized for causal inference and data-driven decision-making across disciplines. In an A/B experiment, for example, an online business randomizes two different treatments (e.g., website designs) to their customers…

统计方法学 · 统计学 2025-01-15 Wenxuan Guo , JungHo Lee , Panos Toulis

This paper studies inference for the local average treatment effect in randomized controlled trials with imperfect compliance where treatment status is determined according to "matched pairs." By "matched pairs," we mean that units are…

计量经济学 · 经济学 2024-06-28 Yuehao Bai , Hongchang Guo , Azeem M. Shaikh , Max Tabord-Meehan

Current approaches to A/B testing in networks focus on limiting interference, the concern that treatment effects can "spill over" from treatment nodes to control nodes and lead to biased causal effect estimation. Prominent methods for…

机器学习 · 计算机科学 2020-04-16 Zahra Fatemi , Elena Zheleva

Causal inference on populations embedded in social networks poses technical challenges, since the typical no interference assumption frequently does not hold. Existing methods developed in the context of network interference rely upon the…

统计方法学 · 统计学 2024-04-12 Vanessa McNealis , Erica E. M. Moodie , Nema Dean

This paper studies inference in randomized controlled trials with covariate-adaptive randomization when there are multiple treatments. More specifically, we study inference about the average effect of one or more treatments relative to…

计量经济学 · 经济学 2019-01-21 Federico A. Bugni , Ivan A. Canay , Azeem M. Shaikh

With increasing data availability, causal effects can be evaluated across different data sets, both randomized controlled trials (RCTs) and observational studies. RCTs isolate the effect of the treatment from that of unwanted (confounding)…