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We investigate saddlepoint approximations applied to the score test statistic in genome-wide association studies with binary phenotypes. The inaccuracy in the normal approximation of the score test statistic increases with increasing sample…

统计方法学 · 统计学 2021-10-11 Pål Vegard Johnsen , Øyvind Bakke , Thea Bjørnland , Andrew Thomas DeWan , Mette Langaas

We have carried out car-following experiments with a 25-car-platoon on an open road section to study the relation between a car's speed and its spacing under various traffic conditions, in the hope to resolve a controversy surrounding this…

适应与自组织系统 · 物理学 2015-09-04 Rui Jiang , Mao-Bin Hu , H. M. Zhang , Zi-You Gao , Bin Jia , Qing-Song Wu

In systematic reviews and meta-analysis, researchers often pool the results of the sample mean and standard deviation from a set of similar clinical trials. A number of the trials, however, reported the study using the median, the minimum…

统计方法学 · 统计学 2016-10-06 Xiang Wan , Wenqian Wang , Jiming Liu , Tiejun Tong

A new approach to adaptive design of clinical trials is proposed in a general multiparameter exponential family setting, based on generalized likelihood ratio statistics and optimal sequential testing theory. These designs are easy to…

统计理论 · 数学 2011-05-25 Jay Bartroff , Tze Leung Lai

A prey animal surveying its environment must decide whether there is a dangerous predator present or not. If there is, it may flee. Flight has an associated cost, so the animal should not flee if there is no danger. However, the prey animal…

种群与进化 · 定量生物学 2011-04-20 Joel Zylberberg , Michael R. DeWeese

Numerical predictions of quantities of interest measured within physical systems rely on the use of mathematical models that should be validated, or at best, not invalidated. Model validation usually involves the comparison of experimental…

计算工程、金融与科学 · 计算机科学 2023-07-19 Antonin Paquette-Rufiange , Serge Prudhomme , Marc Laforest

System modeling is a classical approach to ensure their reliability since it is suitable both for a formal verification and for software testing techniques. In the context of model-based testing an approach combining random testing and…

软件工程 · 计算机科学 2018-06-14 Julien Bernard , Pierre-Cyrille Héam , Olga Kouchnarenko

Background: Adaptive interventions provide a guide for using ongoing information about individuals to decide whether and how to modify the type, amount, delivery modality, or timing of treatment, to improve intervention effectiveness while…

统计方法学 · 统计学 2026-03-12 John J. Dziak , Inbal Nahum-Shani

The paper illustrates an application of the Resampling approach [2] for the estimation of the aircraft circulation plan reliability. Resampling is an intensive computer statistical method, which can be used effectively in the case of small…

应用统计 · 统计学 2013-05-14 Maxim Fioshin

Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.…

机器学习 · 计算机科学 2020-07-02 Abhishek Ghose , Balaraman Ravindran

Importance sampling is used to approximate Bayes' rule in many computational approaches to Bayesian inverse problems, data assimilation and machine learning. This paper reviews and further investigates the required sample size for…

统计计算 · 统计学 2021-02-03 Daniel Sanz-Alonso , Zijian Wang

When autonomous robots interact with humans, such as during autonomous driving, explicit safety guarantees are crucial in order to avoid potentially life-threatening accidents. Many data-driven methods have explored learning probabilistic…

机器人学 · 计算机科学 2021-03-26 Richard Cheng , Richard M. Murray , Joel W. Burdick

Consider the random Dirichlet partition of the interval into $n$ fragments with parameter $\theta >0$. We recall the unordered Ewens sampling formulae from finite Dirichlet partitions. As this is a key variable for estimation purposes,…

统计方法学 · 统计学 2008-09-25 Thierry Huillet , Christian Paroissin

At every phase of scientific research, scientists must decide how to allocate limited resources to pursue the research inquiries with the greatest potential. This prioritization dictates which controlled interventions are studied, awarded…

统计方法学 · 统计学 2022-10-11 Bruce A. Corliss , Yaotian Wang , Heman Shakeri , Philip E. Bourne

Many automated system analysis techniques (e.g., model checking, model-based testing) rely on first obtaining a model of the system under analysis. System modeling is often done manually, which is often considered as a hindrance to adopt…

软件工程 · 计算机科学 2019-11-22 Jingyi Wang , Jun Sun , Qixia Yuan , Jun Pang

This paper investigates the theoretical foundation and develops analytical formulas for sample size and power calculations for causal inference with observational data. By analyzing the variance of an inverse probability weighting estimator…

统计方法学 · 统计学 2026-05-19 Bo Liu , Chengxin Yang , Fan Li

Sample size determination is crucial in experimental design, especially in traffic and transport research. Frequentist statistics require a fixed sample size determined by power analysis, which cannot be adjusted once the experiment starts.…

统计方法学 · 统计学 2025-03-04 Xiaomi Yang , Carol Flannagan , Jonas Bärgman

Almost every software system provides configuration options to tailor the system to the target platform and application scenario. Often, this configurability renders the analysis of every individual system configuration infeasible. To…

软件工程 · 计算机科学 2016-02-17 Flávio Medeiros , Christian Kästner , Márcio Ribeiro , Rohit Gheyi , Sven Apel

Phylodynamics seeks to estimate effective population size fluctuations from molecular sequences of individuals sampled from a population of interest. One way to accomplish this task formulates an observed sequence data likelihood exploiting…

统计方法学 · 统计学 2016-04-27 Michael D. Karcher , Julia A. Palacios , Trevor Bedford , Marc A. Suchard , Vladimir N. Minin

Vertical take-off and landing (VTOL) aircraft do not require a prolonged runway, thus allowing them to land almost anywhere. In recent years, their flexibility has made them popular in development, research, and operation. When compared to…