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相关论文: Exploiting network topology for large-scale infere…

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Network topology inference is a fundamental problem in many applications of network science, such as locating the source of fake news, brain connectivity networks detection, etc. Many real-world situations suffer from a critical problem…

应用统计 · 统计学 2022-06-22 Yupeng Chen , Zhiguo Wang , Xiaojing Shen

Thermodynamic constraints on reactions directions are inherent in the structure of a given biochemical network. However, concrete procedures for determining feasible reaction directions for large-scale metabolic networks are not well…

分子网络 · 定量生物学 2007-05-23 Feng Yang , Feng Qi , Daniel A. Beard

Modeling uncertainty in deep neural networks, despite recent important advances, is still an open problem. Bayesian neural networks are a powerful solution, where the prior over network weights is a design choice, often a normal…

机器学习 · 统计学 2019-10-29 Raanan Y. Rohekar , Yaniv Gurwicz , Shami Nisimov , Gal Novik

Random networks are increasingly used to analyse complex transportation networks, such as airline routes, roads and rail networks. So far, this research has been focused on describing the properties of the networks with the help of random…

物理与社会 · 物理学 2017-09-19 Jürgen Hackl , Bryan T. Adey

Dynamical system models of complex biochemical reaction networks are usually high-dimensional, nonlinear, and contain many unknown parameters. In some cases the reaction network structure dictates that positive equilibria must be unique for…

动力系统 · 数学 2008-09-09 Gheorghe Craciun , J. William Helton , Ruth J. Williams

We propose a novel approach to perform approximate Bayesian inference in complex models such as Bayesian neural networks. The approach is more scalable to large data than Markov Chain Monte Carlo, it embraces more expressive models than…

机器学习 · 统计学 2022-09-07 Joel Janek Dabrowski , Daniel Edward Pagendam

We study the problem of causal discovery through targeted interventions. Starting from few observational measurements, we follow a Bayesian active learning approach to perform those experiments which, in expectation with respect to the…

机器学习 · 统计学 2019-10-10 Julius von Kügelgen , Paul K Rubenstein , Bernhard Schölkopf , Adrian Weller

Network data are increasingly collected along with other variables of interest. Our motivation is drawn from neurophysiology studies measuring brain connectivity networks for a sample of individuals along with their membership to a low or…

统计方法学 · 统计学 2018-09-11 Daniele Durante , David B. Dunson

We present a Bayesian formulation of weighted stochastic block models that can be used to infer the large-scale modular structure of weighted networks, including their hierarchical organization. Our method is nonparametric, and thus does…

机器学习 · 统计学 2018-01-24 Tiago P. Peixoto

Analyzing and understanding the structure of complex relational data is important in many applications including analysis of the connectivity in the human brain. Such networks can have prominent patterns on different scales, calling for a…

机器学习 · 统计学 2013-11-22 Mikkel N. Schmidt , Tue Herlau , Morten Mørup

Recent advances in computing power and the potential to make more realistic assumptions due to increased flexibility have led to the increased prevalence of simulation models in economics. While models of this class, and particularly…

综合经济学 · 经济学 2019-06-12 Donovan Platt

Background:Typically, proteins perform key biological functions by interacting with each other. As a consequence, predicting which protein pairs interact is a fundamental problem. Experimental methods are slow, expensive, and may be error…

生物大分子 · 定量生物学 2022-02-08 Leonardo Martini , Adriano Fazzone , Luca Becchetti

This work examines the problem of topology inference over discrete-time nonlinear stochastic networked dynamical systems. The goal is to recover the underlying digraph linking the network agents, from observations of their state-evolution.…

多智能体系统 · 计算机科学 2019-06-24 Augusto Santos , Vincenzo Matta , Ali H. Sayed

Graphical models are widely used to study biological networks. Interventions on network nodes are an important feature of many experimental designs for the study of biological networks. In this paper we put forward a causal variant of…

统计方法学 · 统计学 2015-06-17 Simon E. F. Spencer , Steven M. Hill , Sach Mukherjee

Reaction networks are mainly used to model the time-evolution of molecules of interacting chemical species. Stochastic models are typically used when the counts of the molecules are low, whereas deterministic models are used when the counts…

概率论 · 数学 2019-10-04 David Anderson , Daniele Cappelletti , Jinsu Kim , Tung Nguyen

Many real-world systems studied are governed by complex, nonlinear dynamics. By modeling these dynamics, we can gain insight into how these systems work, make predictions about how they will behave, and develop strategies for controlling…

机器学习 · 统计学 2019-06-05 Josue Nassar , Scott W. Linderman , Monica Bugallo , Il Memming Park

The characterisation of quantum networks is fundamental to understanding how energy and information propagates through complex systems, with applications in control, communication, error mitigation and energy transfer. In this work, we…

量子物理 · 物理学 2025-09-19 Conall J. Campbell , Matthew Mackinnon , Mauro Paternostro , Diana A. Chisholm

This work addresses multistationarity of fully open reaction networks equipped with mass action kinetics. We improve upon the existing results relating existence of positive feedback loops in a reaction network and multistationarity; and we…

分子网络 · 定量生物学 2025-11-11 Shenghao Yao , AmirHosein Sadeghimanesh , Matthew England

Promising results have driven a recent surge of interest in continuous optimization methods for Bayesian network structure learning from observational data. However, there are theoretical limitations on the identifiability of underlying…

Network inference, the task of reconstructing interactions in a complex system from experimental observables, is a central yet extremely challenging problem in systems biology. While much progress has been made in the last two decades,…

定量方法 · 定量生物学 2024-09-12 Stephen Y Zhang