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Network data arises through observation of relational information between a collection of entities. Recent work in the literature has independently considered when (i) one observes a sample of networks, connectome data in neuroscience being…

统计方法学 · 统计学 2022-06-22 George Bolt , Simón Lunagómez , Christopher Nemeth

Living organisms survive and multiply even though they have uncertain and incomplete information about their environment and imperfect models to predict the consequences of their actions. Bayesian models have been proposed to face this…

新兴技术 · 计算机科学 2015-11-13 Jacques Droulez , David Colliaux , Audrey Houillon , Pierre Bessière

In the last few years, de novo molecular design using machine learning has made great technical progress but its practical deployment has not been as successful. This is mostly owing to the cost and technical difficulty of synthesizing such…

生物大分子 · 定量生物学 2022-04-06 Qi Zhang , Chang Liu , Stephen Wu , Ryo Yoshida

Artificial Intelligence (AI), and in particular, the explainability thereof, has gained phenomenal attention over the last few years. Whilst we usually do not question the decision-making process of these systems in situations where only…

人工智能 · 计算机科学 2021-01-29 Iena Petronella Derks , Alta de Waal

Contagion processes are strongly linked to the network structures on which they propagate, and learning these structures is essential for understanding and intervention on complex network processes such as epidemics and (mis)information…

社会与信息网络 · 计算机科学 2019-08-12 Caitlin Gray , Lewis Mitchell , Matthew Roughan

We consider the problem of inferring the unknown parameters of a stochastic biochemical network model from a single measured time-course of the concentration of some of the involved species. Such measurements are available, e.g., from…

分子网络 · 定量生物学 2011-11-22 Christian L. Muller , Rajesh Ramaswamy , Ivo F. Sbalzarini

Bayesian belief networks can be used to represent and to reason about complex systems with uncertain, incomplete and conflicting information. Belief networks are graphs encoding and quantifying probabilistic dependence and conditional…

人工智能 · 计算机科学 2013-03-08 Carlos Rojas-Guzman , Mark A. Kramer

Most empirical studies of complex networks do not return direct, error-free measurements of network structure. Instead, they typically rely on indirect measurements that are often error-prone and unreliable. A fundamental problem in…

社会与信息网络 · 计算机科学 2021-03-10 Jean-Gabriel Young , George T. Cantwell , M. E. J. Newman

Models with intractable likelihood functions arise in areas including network analysis and spatial statistics, especially those involving Gibbs random fields. Posterior parameter es timation in these settings is termed a doubly-intractable…

统计计算 · 统计学 2018-10-16 Lampros Bouranis , Nial Friel , Florian Maire

This paper describes a Bayesian method for learning causal networks using samples that were selected in a non-random manner from a population of interest. Examples of data obtained by non-random sampling include convenience samples and…

人工智能 · 计算机科学 2013-01-18 Gregory F. Cooper

We present a scalable nonparametric Bayesian method to perform network reconstruction from observed functional behavior that at the same time infers the communities present in the network. We show that the joint reconstruction with…

物理与社会 · 物理学 2019-09-23 Tiago P. Peixoto

In living cells, biochemical reactions are catalyzed by specific enzymes and connect to one another by sharing substrates and products, forming complex networks. In our previous studies, we established a framework determining the responses…

分子网络 · 定量生物学 2017-09-06 Takashi Okada , Atsushi Mochizuki

Heterogeneous molecular entities and their interactions, commonly depicted as a network, are crucial for advancing our systems-level understanding of biology. With recent advancements in high-throughput data generation and a significant…

定量方法 · 定量生物学 2026-03-18 Kishan KC , Rui Li , Paribesh Regmi , Anne R. Haake

Control of complex processes is a major goal of network analyses. Most approaches to control nonlinearly coupled systems require the network topology and/or network dynamics. Unfortunately, neither the full set of participating nodes nor…

分子网络 · 定量生物学 2014-12-23 Jason Shulman , Frank Malatino , Alexander Mo , Killian Ryan , Gemunu H. Gunaratne

Analyzing synthesis pathways for target molecules in a chemical reaction network annotated with information on the kinetics of individual reactions is an area of active study. This work presents a computational methodology for searching for…

计算工程、金融与科学 · 计算机科学 2026-03-31 Adittya Pal , Rolf Fagerberg , Jakob Lykke Andersen , Peter Dittrich , Daniel Merkle

We propose a method for gene expression based analysis of cancer phenotypes incorporating network biology knowledge through unsupervised construction of computational graphs. The structural construction of the computational graphs is driven…

Bayesian sociality models provide a scalable and flexible alternative for network analysis, capturing degree heterogeneity through actor-specific parameters while mitigating the identifiability challenges of latent space models. This paper…

统计方法学 · 统计学 2025-03-20 Juan Sosa , Carlo Martínez

Many nonequilibrium systems, such as biochemical reactions and socioeconomic interactions, can be described by reaction-diffusion equations that demonstrate a wide variety of complex spatiotemporal patterns. The diversity of the morphology…

计算物理 · 物理学 2022-02-02 Christian Scholz , Sandy Scholz

A variety of natural phenomena comprises a huge number of competing reactions and short-lived intermediates. Any study of such processes requires the discovery and accurate modeling of their underlying reaction network. However, this task…

化学物理 · 物理学 2014-05-27 Paolo Elvati , Angela Violi

Complex network theory provides a powerful framework to statistically investigate the topology of local and non-local statistical interrelationships, i.e. teleconnections, in the climate system. Climate networks constructed from the same…

数据分析、统计与概率 · 物理学 2009-07-27 Jonathan F. Donges , Yong Zou , Norbert Marwan , Jürgen Kurths