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We estimate treatment cost-savings from early cancer diagnosis. For breast, lung, prostate and colorectal cancers and melanoma, which account for more than 50% of new incidences projected in 2017, we combine published cancer treatment cost…

组织与器官 · 定量生物学 2019-04-03 Zura Kakushadze , Rakesh Raghubanshi , Willie Yu

Women with an increased life-time risk of breast cancer undergo supplemental annual screening MRI. We propose to predict the risk of developing breast cancer within one year based on the current MRI, with the objective of reducing screening…

The UK Biobank is a large-scale health resource comprising genetic, environmental and medical information on approximately 500,000 volunteer participants in the UK, recruited at ages 40--69 during the years 2006--2010. The project monitors…

应用统计 · 统计学 2021-03-16 Malka Gorfine , Nir Keret , Asaf Ben Arie , David Zucker , Li Hsu

We discuss a shift in perspective from traditional approaches to breast cancer risk prediction: modelling families rather than individuals as unit of analysis. By investigating the latent familial risk underlying breast cancer diagnoses, we…

应用统计 · 统计学 2025-08-25 Maria Veronica Vinattieri , Marco Bonetti , Kamila Czene

Breast cancer is the most frequently reported cancer type among the women around the globe and beyond that it has the second highest female fatality rate among all cancer types. Despite all the progresses made in prevention and early…

机器学习 · 计算机科学 2018-11-08 Hadi Mansourifar , Weidong Shi

Multi-gene panel testing allows efficient detection of pathogenic variants in cancer susceptibility genes including moderate-risk genes such as ATM and PALB2. A growing number of studies examine the risk of breast cancer (BC) conferred by…

统计方法学 · 统计学 2024-02-26 Thanthirige Lakshika M. Ruberu , Danielle Braun , Giovanni Parmigiani , Swati Biswas

In observational studies, covariate imbalance generates confounding, resulting in biased comparisons. Although propensity score-based weighting approaches facilitate unconfounded group comparisons for implicit target populations, existing…

统计方法学 · 统计学 2023-07-03 Subharup Guha , David C. Christiani , Yi Li

Timely pre- and post-diagnosis check-ups are critical for cancer patients, across all cancer types, as these often lead to better outcomes. Several socio-demographic properties have been identified as strongly connected with both cancer's…

应用统计 · 统计学 2023-05-08 Elizaveta Savchenko , Ariel Rosenfeld , Svetlana Bunimovich-Mendrazitsky

In a recent article in PNAS, Case and Deaton show a figure illustrating "a marked increase in the all-cause mortality of middle-aged white non-Hispanic men and women in the United States between 1999 and 2013." The authors state that their…

应用统计 · 统计学 2016-04-27 Andrew Gelman , Jonathan Auerbach

Cancer disease is one of the leading causes of death all over the world. Breast cancer, which is a common cancer disease especially in women, is quite common. The most important tool used for early detection of this cancer type, which…

图像与视频处理 · 电气工程与系统科学 2020-12-11 Ali Narin

Background. Diet and inflammation are critical factors influencing cancer risk. However, the combined impact of nutritional status and inflammatory biomarkers on cancer status and type, using machine learning (ML), remains underexplored.…

定量方法 · 定量生物学 2025-04-22 Yuqing Liu , Meng Zhao , Guanlan Hu , Yuchen Zhang

The need for more usable and explainable machine learning models in healthcare increases the importance of developing and utilizing causal discovery algorithms, which aim to discover causal relations by analyzing observational data.…

机器学习 · 计算机科学 2023-05-31 Mugariya Farooq , Shahad Hardan , Aigerim Zhumbhayeva , Yujia Zheng , Preslav Nakov , Kun Zhang

Tomasetti and Vogelstein (2015a) find that the incidence of a set of cancer types is correlated with the total number of normal stem cell divisions. Here, we separate the effects of standing stem cell number (i.e., organ or tissue size) and…

种群与进化 · 定量生物学 2015-02-05 Robert Noble , Oliver Kaltz , Michael E Hochberg

Prostate cancer is one of the leading causes of cancer-related mortality among men in the U.S. We examined the role of neighborhood obesogenic attributes on prostate cancer risk and mortality in the Southern Community Cohort Study (SCCS).…

In cancer epidemiology, the \emph{relative survival framework} is used to quantify the hazard associated with cancer by comparing the all-cause mortality hazard in cancer patients to that of the general population. This framework assumes…

应用统计 · 统计学 2024-11-05 Piyali Basak , Antonio R. Linero , Camille Maringe , F. Javier Rubio

Among American women, the rate of breast cancer is only second to lung cancer. An estimated 12.4% women will develop breast cancer over the course of their lifetime. The widespread use of social media across the socio-economic spectrum…

计算机与社会 · 计算机科学 2019-05-30 Francois Modave , Yunpeng Zhao , Janice Krieger , Zhe He , Yi Guo , Jinhai Huo , Mattia Prosperi , Jiang Bian

We investigated the data-driven relationship between features in the tumor microenvironment (TME) and the overall and 5-year survival in triple-negative breast cancer (TNBC) and non-TNBC (NTNBC) patients by using Explainable Artificial…

In public health, it is critical for policymakers to assess the relationship between the disease prevalence and associated risk factors or clinical characteristics, facilitating effective resources allocation. However, for diseases like…

Breast cancer is prevalent in Ethiopia that accounts 34% among women cancer patients. The diagnosis technique in Ethiopia is manual which was proven to be tedious, subjective, and challenging. Deep learning techniques are revolutionizing…

计算机视觉与模式识别 · 计算机科学 2020-08-20 Simon Hadush , Yaecob Girmay , Abiot Sinamo , Gebrekirstos Hagos

Objectives: Most cancer data sources lack information on metastatic recurrence. Electronic medical records (EMRs) and population-based cancer registries contain complementary information on cancer treatment and outcomes, yet are rarely used…