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At the single-neuron level, precisely timed spikes can either constitute firing-rate codes or spike-pattern codes that utilize the relative timing between consecutive spikes. There has been little experimental support for the hypothesis…

神经元与认知 · 定量生物学 2009-12-18 Hugo Gabriel Eyherabide , Ariel Rokem , Andreas V. M. Herz , Ines Samengo

We introduce a model of DNA sequence evolution which can account for biases in mutation rates that depend on the identity of the neighboring bases. An analytic solution for this class of non-equilibrium models is developed by adopting…

生物物理 · 物理学 2007-05-23 Peter F. Arndt , Christopher B. Burge , Terence Hwa

The central dogma of molecular biology is the principal framework for understanding how nucleic acid information is propagated and used by living systems to create complex biomolecules. Here, by integrating the structural and dynamic…

生物物理 · 物理学 2018-10-04 Jihoon Shin , Junghoon Kim , Sung Ha Park , Tai Hwan Ha

Neural finite-state transducers (NFSTs) form an expressive family of neurosymbolic sequence transduction models. An NFST models each string pair as having been generated by a latent path in a finite-state transducer. As they are deep…

机器学习 · 计算机科学 2023-12-22 Weiting Tan , Chu-cheng Lin , Jason Eisner

Genomic aberrations, such as somatic copy number alterations, are frequently observed in tumor tissue. Recurrent aberrations, occurring in the same region across multiple subjects, are of interest because they may highlight genes associated…

统计理论 · 数学 2014-03-11 Vonn Walter , Fred A. Wright , Andrew B. Nobel

We propose a one-dimensional model of a string decorated with adhesion molecules (stickers) to mimic multicomponent membranes in restricted geometries. The string is bounded by two parallel walls and it interacts with one of them by short…

软凝聚态物质 · 物理学 2009-11-10 B. Rozycki , M. Napiorkowski

Structural and functional heterogeneity are hallmarks of cortical circuits, from broad degree distributions in the mouse connectome to diverse intrinsic neuronal timescales. Yet a mechanistic link between connectivity heterogeneity and…

神经元与认知 · 定量生物学 2026-03-05 Marco Zenari , Luca Taffarello , Luca Mazzucato , Amos Maritan , Samir Suweis

The article explores an encoding and structural information processing approach using sparse bit vectors and fixed-length linear vectors. The following are presented: a discrete method of speculative stochastic dimensionality reduction of…

机器学习 · 计算机科学 2025-08-05 Dmitriy Kashitsyn , Dmitriy Shabanov

The main statistical distributions applicable to the analysis of genome architecture and genome tracks are briefly discussed and critically assessed. Although the observed features in distributions of element lengths can be equally well…

其他定量生物学 · 定量生物学 2015-06-17 V. R. Chechetkin

The majority of dynamical studies in power systems focus on the high voltage transmission grids where models consider large generators interacting with crude aggregations of individual small loads. However, new phenomena have been observed…

物理与社会 · 物理学 2015-06-12 Charlie Duclut , Scott Backhaus , Michael Chertkov

Single cell responses are shaped by the geometry of signaling kinetic trajectories carved in a multidimensional space spanned by signaling protein abundances. It is however challenging to assay large number (>3) of signaling species in…

定量方法 · 定量生物学 2017-07-27 Sayak Mukherjee , David Stewart , William Stewart , Lewis L. Lanier , Jayajit Das

We investigate the non-Markovian dynamics of quantum correlation between two initially entangled nitrogen-vacancy centers (NVC) embedded in photonic crystal cavities (PCC). We find that a finite quantum correlation is preserved even…

量子物理 · 物理学 2013-02-19 W. L. Yang , Jun-Hong An , Chengjie Zhang , M. Feng , C. H. Oh

Collective temporal organization in complex systems is commonly attributed to synchronization, resonance, or proximity to dynamical instabilities. Here we identify a distinct mechanism by which coherent, synchronization-like behavior can…

适应与自组织系统 · 物理学 2026-03-10 V. Troude , D. Sornette

A stretched DNA molecule which is also under- or overwound, undergoes a buckling transition forming intertwined looped domains called plectonemes. Here we develop a simple theory that extends the two-phase model of stretched supercoiled…

软凝聚态物质 · 物理学 2024-11-01 Midas Segers , Enrico Skoruppa , Helmut Schiessel , Enrico Carlon

We study the fraction $f$ of nucleotides involved in the formation of a cactus--like secondary structure of random heteropolymer RNA--like molecules. In the low--temperature limit we study this fraction as a function of the number $c$ of…

基因组学 · 定量生物学 2013-05-30 O. V. Valba , M. V. Tamm , S. K. Nechaev

We deal here with three metastable systems: 1{\textdegree}- the dowser texture, 2{\textdegree}- supertwistedcholesterics and 3{\textdegree}- hypotwisted cholesterics. We outline remarkable properties of tropisms of the dowser texture…

软凝聚态物质 · 物理学 2023-06-21 P. Pieranski , M. Godinho

We investigate the statistical behavior of a system comprising fore-aft symmetric rods confined between two vertically vibrating plates using numerical simulations closely resembling the experimental setup studied by Narayan et al., Science…

软凝聚态物质 · 物理学 2024-08-20 Abhishek Sharma , Harsh Soni

This work describes a new algorithm for creating a superposition over the edge set of a graph, encoding a quantum sample of the random walk stationary distribution. The algorithm requires a number of quantum walk steps scaling as…

量子物理 · 物理学 2019-04-26 Simon Apers

The evolution of the atomic structures of the combinatorial library of Sm-substituted thin film BiFeO3 along the phase transition boundary from the ferroelectric rhombohedral phase to the non-ferroelectric orthorhombic phase is explored…

数据分析、统计与概率 · 物理学 2021-03-03 Chris Nelson , Anna N. Morozovska , Maxim A. Ziatdinov , Eugene A. Eliseev , Xiaohang Zhang , Ichiro Takeuchi , Sergei V. Kalinin

We identify a new class of non-Hermitian causal processes that produce statistically significant temporal correlations invisible to conventional spectral methods. Using a generative model with a strictly causal memory kernel, we demonstrate…

统计力学 · 物理学 2026-04-01 Mario J. Pinheiro
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